Synthesis of simplified Tetrahydropyran Hybrids with potential Antiproliferative Activity
Resumen:
In recent years, our group has synthesized oxazole-tetrahydropyran hybrid compounds, some of which have shown antiproliferative activity against human tumour cells and selectivity with respect to normal cells. We are currently looking for derivatives of these compounds and facing certain limitations in terms of structural modifications. For this reason, we have proposed new hybrids taking tetrahydropyran as the main building block (due to its individual activity and presence in anticancer compounds), with the aim of finding structurally simplified lead compounds, which allow subsequent derivatizations and improve the selectivity and antiproliferative activity. El poster fue presentado en #RSCPoster 2023, un evento anual a través de la red social X, organizado por la Royal Society of Chemistry, que busca que la comunidad científica comparte sus investigaciones.
| 2023 | |
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Agencia Nacional de Investigación e Innovación Alexander von Humboldt Foundation |
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Hybrids Tetrahydropyran Antiproliferative Ciencias Naturales y Exactas Ciencias Químicas Química Orgánica |
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| Inglés | |
| Agencia Nacional de Investigación e Innovación | |
| REDI | |
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https://hdl.handle.net/20.500.12381/3364
https://twitter.com/VaneQ_10/status/1630549665593606144 |
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| Acceso abierto | |
| Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional. (CC BY-NC-ND) |
| _version_ | 1814959263668240384 |
|---|---|
| author | Quintana, Vanesa |
| author2 | Padrón, Juan Ignacio Martín, Víctor Sotero Padrón, José Manuel Davyt, Danilo Valdomir, Guillermo |
| author2_role | author author author author author |
| author_facet | Quintana, Vanesa Padrón, Juan Ignacio Martín, Víctor Sotero Padrón, José Manuel Davyt, Danilo Valdomir, Guillermo |
| author_role | author |
| bitstream.checksum.fl_str_mv | a4ce09f01b5dd771727aa05c73851623 deb546fa6c50721c9df8c23d6ec01ec7 |
| bitstream.checksumAlgorithm.fl_str_mv | MD5 MD5 |
| bitstream.url.fl_str_mv | https://redi.anii.org.uy/jspui/bitstream/20.500.12381/3364/2/license.txt https://redi.anii.org.uy/jspui/bitstream/20.500.12381/3364/1/P%c3%b3ster%20RSC%20twitter%20conference%202023.png |
| collection | REDI |
| dc.creator.none.fl_str_mv | Quintana, Vanesa Padrón, Juan Ignacio Martín, Víctor Sotero Padrón, José Manuel Davyt, Danilo Valdomir, Guillermo |
| dc.date.accessioned.none.fl_str_mv | 2023-12-22T22:17:15Z |
| dc.date.available.none.fl_str_mv | 2023-12-22T22:17:15Z |
| dc.date.issued.none.fl_str_mv | 2023-02-28 |
| dc.description.abstract.none.fl_txt_mv | In recent years, our group has synthesized oxazole-tetrahydropyran hybrid compounds, some of which have shown antiproliferative activity against human tumour cells and selectivity with respect to normal cells. We are currently looking for derivatives of these compounds and facing certain limitations in terms of structural modifications. For this reason, we have proposed new hybrids taking tetrahydropyran as the main building block (due to its individual activity and presence in anticancer compounds), with the aim of finding structurally simplified lead compounds, which allow subsequent derivatizations and improve the selectivity and antiproliferative activity. El poster fue presentado en #RSCPoster 2023, un evento anual a través de la red social X, organizado por la Royal Society of Chemistry, que busca que la comunidad científica comparte sus investigaciones. |
| dc.description.sponsorship.none.fl_txt_mv | Agencia Nacional de Investigación e Innovación Alexander von Humboldt Foundation |
| dc.identifier.anii.es.fl_str_mv | FCE_3_2020_1_162136 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12381/3364 |
| dc.identifier.url.none.fl_str_mv | https://twitter.com/VaneQ_10/status/1630549665593606144 |
| dc.language.iso.none.fl_str_mv | eng |
| dc.relation.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12381/3362 https://hdl.handle.net/20.500.12381/3363 |
| dc.rights.*.fl_str_mv | Acceso abierto |
| dc.rights.license.none.fl_str_mv | Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional. (CC BY-NC-ND) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.es.fl_str_mv | #RSCPoster 2023 |
| dc.source.none.fl_str_mv | reponame:REDI instname:Agencia Nacional de Investigación e Innovación instacron:Agencia Nacional de Investigación e Innovación |
| dc.subject.anii.none.fl_str_mv | Ciencias Naturales y Exactas Ciencias Químicas Química Orgánica |
| dc.subject.es.fl_str_mv | Hybrids Tetrahydropyran Antiproliferative |
| dc.title.none.fl_str_mv | Synthesis of simplified Tetrahydropyran Hybrids with potential Antiproliferative Activity |
| dc.type.es.fl_str_mv | Documento de conferencia |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/conferenceObject |
| dc.type.version.es.fl_str_mv | Publicado |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | In recent years, our group has synthesized oxazole-tetrahydropyran hybrid compounds, some of which have shown antiproliferative activity against human tumour cells and selectivity with respect to normal cells. We are currently looking for derivatives of these compounds and facing certain limitations in terms of structural modifications. For this reason, we have proposed new hybrids taking tetrahydropyran as the main building block (due to its individual activity and presence in anticancer compounds), with the aim of finding structurally simplified lead compounds, which allow subsequent derivatizations and improve the selectivity and antiproliferative activity. El poster fue presentado en #RSCPoster 2023, un evento anual a través de la red social X, organizado por la Royal Society of Chemistry, que busca que la comunidad científica comparte sus investigaciones. |
| eu_rights_str_mv | openAccess |
| format | conferenceObject |
| id | REDI_511cb7d94227cf324a38320d430633ae |
| identifier_str_mv | FCE_3_2020_1_162136 |
| instacron_str | Agencia Nacional de Investigación e Innovación |
| institution | Agencia Nacional de Investigación e Innovación |
| instname_str | Agencia Nacional de Investigación e Innovación |
| language | eng |
| network_acronym_str | REDI |
| network_name_str | REDI |
| oai_identifier_str | oai:redi.anii.org.uy:20.500.12381/3364 |
| publishDate | 2023 |
| reponame_str | REDI |
| repository.mail.fl_str_mv | jmaldini@anii.org.uy |
| repository.name.fl_str_mv | REDI - Agencia Nacional de Investigación e Innovación |
| repository_id_str | 9421 |
| rights_invalid_str_mv | Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional. (CC BY-NC-ND) Acceso abierto |
| spelling | Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional. (CC BY-NC-ND)Acceso abiertoinfo:eu-repo/semantics/openAccess2023-12-22T22:17:15Z2023-12-22T22:17:15Z2023-02-28https://hdl.handle.net/20.500.12381/3364FCE_3_2020_1_162136https://twitter.com/VaneQ_10/status/1630549665593606144In recent years, our group has synthesized oxazole-tetrahydropyran hybrid compounds, some of which have shown antiproliferative activity against human tumour cells and selectivity with respect to normal cells. We are currently looking for derivatives of these compounds and facing certain limitations in terms of structural modifications. For this reason, we have proposed new hybrids taking tetrahydropyran as the main building block (due to its individual activity and presence in anticancer compounds), with the aim of finding structurally simplified lead compounds, which allow subsequent derivatizations and improve the selectivity and antiproliferative activity. El poster fue presentado en #RSCPoster 2023, un evento anual a través de la red social X, organizado por la Royal Society of Chemistry, que busca que la comunidad científica comparte sus investigaciones.Agencia Nacional de Investigación e InnovaciónAlexander von Humboldt Foundationenghttps://hdl.handle.net/20.500.12381/3362https://hdl.handle.net/20.500.12381/3363#RSCPoster 2023reponame:REDIinstname:Agencia Nacional de Investigación e Innovacióninstacron:Agencia Nacional de Investigación e InnovaciónHybridsTetrahydropyranAntiproliferativeCiencias Naturales y ExactasCiencias QuímicasQuímica OrgánicaSynthesis of simplified Tetrahydropyran Hybrids with potential Antiproliferative ActivityDocumento de conferenciaPublicadoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectUniversidad de la República. Facultad de QuímicaUniversidad de La Laguna. IUBO-AG//Ciencias Naturales y Exactas/Ciencias Químicas/Química OrgánicaQuintana, VanesaPadrón, Juan IgnacioMartín, Víctor SoteroPadrón, José ManuelDavyt, DaniloValdomir, GuillermoLICENSElicense.txtlicense.txttext/plain; charset=utf-84967https://redi.anii.org.uy/jspui/bitstream/20.500.12381/3364/2/license.txta4ce09f01b5dd771727aa05c73851623MD52ORIGINALPóster RSC twitter conference 2023.pngPóster RSC twitter conference 2023.pngPósterimage/png1229374https://redi.anii.org.uy/jspui/bitstream/20.500.12381/3364/1/P%c3%b3ster%20RSC%20twitter%20conference%202023.pngdeb546fa6c50721c9df8c23d6ec01ec7MD5120.500.12381/33642024-01-10 14:12:31.116oai:redi.anii.org.uy:20.500.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- Agencia Nacional de Investigación e Innovaciónfalse |
| spellingShingle | Synthesis of simplified Tetrahydropyran Hybrids with potential Antiproliferative Activity Quintana, Vanesa Hybrids Tetrahydropyran Antiproliferative Ciencias Naturales y Exactas Ciencias Químicas Química Orgánica |
| status_str | publishedVersion |
| title | Synthesis of simplified Tetrahydropyran Hybrids with potential Antiproliferative Activity |
| title_full | Synthesis of simplified Tetrahydropyran Hybrids with potential Antiproliferative Activity |
| title_fullStr | Synthesis of simplified Tetrahydropyran Hybrids with potential Antiproliferative Activity |
| title_full_unstemmed | Synthesis of simplified Tetrahydropyran Hybrids with potential Antiproliferative Activity |
| title_short | Synthesis of simplified Tetrahydropyran Hybrids with potential Antiproliferative Activity |
| title_sort | Synthesis of simplified Tetrahydropyran Hybrids with potential Antiproliferative Activity |
| topic | Hybrids Tetrahydropyran Antiproliferative Ciencias Naturales y Exactas Ciencias Químicas Química Orgánica |
| url | https://hdl.handle.net/20.500.12381/3364 https://twitter.com/VaneQ_10/status/1630549665593606144 |
