Radiosynthesis of [11C](S,S)-SAM by biocatalytic methodologies as a potential prostate cancer imagen agent
Resumen:
This study focuses on prostate cancer and the need for better biomarkers for accurate diagnosis. Sarcosine, a metabolite linked to cancer progression, is produced via GNMT using (S,S)-SAM, making radiolabeled [¹¹C]-SAM a promising diagnostic tracer. The researchers developed an automated method to synthesize [¹¹C]-SAM using an immobilized enzyme system. Starting from [¹¹C]CO₂, they produced [¹¹C]methionine and then converted it into [¹¹C]-SAM, optimizing reaction conditions and purification. The method achieved high conversion (82%) and radiochemical purity (97%), demonstrating an efficient automated synthesis, though further biological evaluation is needed.
| 2023 | |
| Agencia Nacional de Investigación e Innovación | |
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[ 11C](S,S)-SAM Prostate Cancer (S, S)-adenosylmethionine Ciencias Naturales y Exactas Ciencias Químicas |
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| Inglés | |
| Agencia Nacional de Investigación e Innovación | |
| REDI | |
| https://hdl.handle.net/20.500.12381/5562 | |
| Acceso abierto | |
| Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional. (CC BY-NC-ND) |
