Configurable preamplifier for intracortical neural signal recording

González, Ismael

Supervisor(es): Miguez, Matías - Martínez, Natalia - Sapriza, Juan

Resumen:

This work presents the design, simulation, and layout of a fully differential low noise preamplifier for intracortical electroencephalography (iEEG) recording, implemented in TSMC 65 nm LP CMOS technology with a 1 V supply voltage. The circuit is intended as the first stage of an Analog Front-End (AFE) for an implantable device that records and transmits the information wirelessly. The AFE must amplify microvolt level neural signals while rejecting large electrode DC offsets, while meeting the provided power and area constraints. After reviewing existing architectures, the design was finally based on a Miller Compensated Capacitive Feedback Network (MCCFN) topology with a two stage operational transconductance amplifier (OTA). Input AC coupling through Metal/Insulator/Metal (MIM) capacitors blocks the DC electrode potential, and pseudo resistors implemented with thick oxide PMOS transistors set the high pass cutoff frequency below 1 Hz. AC, noise, and stability simulation tests were performed and then the layout implementation was made. The full chip tape-out is scheduled for July 7th.

Detalles Bibliográficos
2026
Preamplifiers
Brain-computer interfaces
Analog integrated circuits
Biomedical instruments
Preamplificadores
Interfaces cerebro-computadora
Circuitos integrados analógicos
Instrumentos biomédicos
Memoria de grado (Ingeniería en electrónica)
Universidad Católica del Uruguay
LIBERI
https://hdl.handle.net/10895/7570
Acceso abierto
Licencia Creative Commons Atribución – No Comercial – Sin Derivadas (CC BY-NC-ND 4.0)
_version_ 1878474500041867264
author González, Ismael
author_facet González, Ismael
author_role author
bitstream.checksum.fl_str_mv 63405c7593e29d86459630b5dc12ef11
40f5922ee6c15fece1c80fd7406b5bec
5e9a4b22b13a90309dfaefac39082739
9a5b1dd0d378a445c08d62043c5c8b67
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
bitstream.url.fl_str_mv https://liberi.ucu.edu.uy/bitstreams/3273507c-a40f-4555-acf5-96ea3a4f8433/download
https://liberi.ucu.edu.uy/bitstreams/8a7a55c8-d60b-444e-8ca1-97fb25147555/download
https://liberi.ucu.edu.uy/bitstreams/5af36046-4c90-4f3a-92a9-9fa285eb331c/download
https://liberi.ucu.edu.uy/bitstreams/2d165ea8-9389-44dc-bc43-eaa05db8e36e/download
collection LIBERI
dc.creator.advisor.none.fl_str_mv Miguez, Matías
Martínez, Natalia
Sapriza, Juan
dc.creator.none.fl_str_mv González, Ismael
dc.date.accessioned.none.fl_str_mv 2026-09-15T21:17:37Z
dc.date.issued.none.fl_str_mv 2026-06-02
dc.description.abstract.none.fl_txt_mv This work presents the design, simulation, and layout of a fully differential low noise preamplifier for intracortical electroencephalography (iEEG) recording, implemented in TSMC 65 nm LP CMOS technology with a 1 V supply voltage. The circuit is intended as the first stage of an Analog Front-End (AFE) for an implantable device that records and transmits the information wirelessly. The AFE must amplify microvolt level neural signals while rejecting large electrode DC offsets, while meeting the provided power and area constraints. After reviewing existing architectures, the design was finally based on a Miller Compensated Capacitive Feedback Network (MCCFN) topology with a two stage operational transconductance amplifier (OTA). Input AC coupling through Metal/Insulator/Metal (MIM) capacitors blocks the DC electrode potential, and pseudo resistors implemented with thick oxide PMOS transistors set the high pass cutoff frequency below 1 Hz. AC, noise, and stability simulation tests were performed and then the layout implementation was made. The full chip tape-out is scheduled for July 7th.
dc.format.extent.es.fl_str_mv 84 p.
dc.format.mimetype.none.fl_str_mv application/pdf
dc.format.none.fl_str_mv application/pdf
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10895/7570
dc.language.iso.none.fl_str_mv en_US
dc.publisher.country.none.fl_str_mv UY
dc.rights.license.none.fl_str_mv Licencia Creative Commons Atribución – No Comercial – Sin Derivadas (CC BY-NC-ND 4.0)
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.source.none.fl_str_mv reponame:LIBERI
instname:Universidad Católica del Uruguay
instacron:Universidad Católica del Uruguay
dc.subject.en.fl_str_mv Preamplifiers
Brain-computer interfaces
Analog integrated circuits
Biomedical instruments
dc.subject.es.fl_str_mv Preamplificadores
Interfaces cerebro-computadora
Circuitos integrados analógicos
Instrumentos biomédicos
Memoria de grado (Ingeniería en electrónica)
dc.title.none.fl_str_mv Configurable preamplifier for intracortical neural signal recording
dc.type.none.fl_str_mv info:eu-repo/semantics/bachelorThesis
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/acceptedVersion
description This work presents the design, simulation, and layout of a fully differential low noise preamplifier for intracortical electroencephalography (iEEG) recording, implemented in TSMC 65 nm LP CMOS technology with a 1 V supply voltage. The circuit is intended as the first stage of an Analog Front-End (AFE) for an implantable device that records and transmits the information wirelessly. The AFE must amplify microvolt level neural signals while rejecting large electrode DC offsets, while meeting the provided power and area constraints. After reviewing existing architectures, the design was finally based on a Miller Compensated Capacitive Feedback Network (MCCFN) topology with a two stage operational transconductance amplifier (OTA). Input AC coupling through Metal/Insulator/Metal (MIM) capacitors blocks the DC electrode potential, and pseudo resistors implemented with thick oxide PMOS transistors set the high pass cutoff frequency below 1 Hz. AC, noise, and stability simulation tests were performed and then the layout implementation was made. The full chip tape-out is scheduled for July 7th.
eu_rights_str_mv openAccess
format bachelorThesis
id LIBERI_ad620b3f8237847cd03da1ff4ec6bd2a
instacron_str Universidad Católica del Uruguay
institution Universidad Católica del Uruguay
instname_str Universidad Católica del Uruguay
language_invalid_str_mv en_US
network_acronym_str LIBERI
network_name_str LIBERI
oai_identifier_str oai:liberi.ucu.edu.uy:10895/7570
publishDate 2026
reponame_str LIBERI
repository.mail.fl_str_mv franco.pertusso@ucu.edu.uy
repository.name.fl_str_mv LIBERI - Universidad Católica del Uruguay
repository_id_str 10342
rights_invalid_str_mv Licencia Creative Commons Atribución – No Comercial – Sin Derivadas (CC BY-NC-ND 4.0)
https://creativecommons.org/licenses/by-nc-nd/4.0/
spelling Licencia Creative Commons Atribución – No Comercial – Sin Derivadas (CC BY-NC-ND 4.0)info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/2026-09-15T21:17:37Z2026-06-02https://hdl.handle.net/10895/7570This work presents the design, simulation, and layout of a fully differential low noise preamplifier for intracortical electroencephalography (iEEG) recording, implemented in TSMC 65 nm LP CMOS technology with a 1 V supply voltage. The circuit is intended as the first stage of an Analog Front-End (AFE) for an implantable device that records and transmits the information wirelessly. The AFE must amplify microvolt level neural signals while rejecting large electrode DC offsets, while meeting the provided power and area constraints. After reviewing existing architectures, the design was finally based on a Miller Compensated Capacitive Feedback Network (MCCFN) topology with a two stage operational transconductance amplifier (OTA). Input AC coupling through Metal/Insulator/Metal (MIM) capacitors blocks the DC electrode potential, and pseudo resistors implemented with thick oxide PMOS transistors set the high pass cutoff frequency below 1 Hz. AC, noise, and stability simulation tests were performed and then the layout implementation was made. The full chip tape-out is scheduled for July 7th.application/pdf84 p.application/pdfen_USPreamplifiersBrain-computer interfacesAnalog integrated circuitsBiomedical instrumentsPreamplificadoresInterfaces cerebro-computadoraCircuitos integrados analógicosInstrumentos biomédicosMemoria de grado (Ingeniería en electrónica)Configurable preamplifier for intracortical neural signal recordinginfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/acceptedVersionUYreponame:LIBERIinstname:Universidad Católica del Uruguayinstacron:Universidad Católica del UruguayGonzález, IsmaelMiguez, MatíasMartínez, NataliaSapriza, JuanORIGINAL131173.pdfIsmael_González_Entrega_Final_V3.pdfapplication/pdf44753049https://liberi.ucu.edu.uy/bitstreams/3273507c-a40f-4555-acf5-96ea3a4f8433/download63405c7593e29d86459630b5dc12ef11MD51trueAnonymousREADLICENSElicense.txtWritten by org.dspace.content.LicenseUtilstext/plain; charset=utf-81021https://liberi.ucu.edu.uy/bitstreams/8a7a55c8-d60b-444e-8ca1-97fb25147555/download40f5922ee6c15fece1c80fd7406b5becMD52falseAnonymousREADTEXT131173.pdf.txtWritten by FormatFilter org.dspace.app.mediafilter.TikaTextExtractionFilter on 2026-09-16T01:01:15Z (GMT).Extracted texttext/plain88156https://liberi.ucu.edu.uy/bitstreams/5af36046-4c90-4f3a-92a9-9fa285eb331c/download5e9a4b22b13a90309dfaefac39082739MD53falseAnonymousREADTHUMBNAIL131173.pdf.jpgWritten by FormatFilter org.dspace.app.mediafilter.PDFBoxThumbnail on 2026-09-16T01:01:16Z (GMT).Generated Thumbnailimage/jpeg3223https://liberi.ucu.edu.uy/bitstreams/2d165ea8-9389-44dc-bc43-eaa05db8e36e/download9a5b1dd0d378a445c08d62043c5c8b67MD54falseAnonymousREAD10895/75702026-09-16 03:01:16.647https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessopen.accessoai:liberi.ucu.edu.uy:10895/7570https://liberi.ucu.edu.uyInstitucionalhttps://liberi.ucu.edu.uy/Universidadhttps://www.ucu.edu.uy/https://liberi.ucu.edu.uy/server/oaifranco.pertusso@ucu.edu.uyUruguayopendoar:103422026-09-16T01:01:16LIBERI - Universidad Católica del 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
spellingShingle Configurable preamplifier for intracortical neural signal recording
González, Ismael
Preamplifiers
Brain-computer interfaces
Analog integrated circuits
Biomedical instruments
Preamplificadores
Interfaces cerebro-computadora
Circuitos integrados analógicos
Instrumentos biomédicos
Memoria de grado (Ingeniería en electrónica)
status_str publishedVersion
title Configurable preamplifier for intracortical neural signal recording
title_full Configurable preamplifier for intracortical neural signal recording
title_fullStr Configurable preamplifier for intracortical neural signal recording
title_full_unstemmed Configurable preamplifier for intracortical neural signal recording
title_short Configurable preamplifier for intracortical neural signal recording
title_sort Configurable preamplifier for intracortical neural signal recording
topic Preamplifiers
Brain-computer interfaces
Analog integrated circuits
Biomedical instruments
Preamplificadores
Interfaces cerebro-computadora
Circuitos integrados analógicos
Instrumentos biomédicos
Memoria de grado (Ingeniería en electrónica)
url https://hdl.handle.net/10895/7570