Configurable preamplifier for intracortical neural signal recording
Supervisor(es): Miguez, Matías - Martínez, Natalia - Sapriza, Juan
Resumen:
This work presents the design, simulation, and layout of a fully differential low noise preamplifier for intracortical electroencephalography (iEEG) recording, implemented in TSMC 65 nm LP CMOS technology with a 1 V supply voltage. The circuit is intended as the first stage of an Analog Front-End (AFE) for an implantable device that records and transmits the information wirelessly. The AFE must amplify microvolt level neural signals while rejecting large electrode DC offsets, while meeting the provided power and area constraints. After reviewing existing architectures, the design was finally based on a Miller Compensated Capacitive Feedback Network (MCCFN) topology with a two stage operational transconductance amplifier (OTA). Input AC coupling through Metal/Insulator/Metal (MIM) capacitors blocks the DC electrode potential, and pseudo resistors implemented with thick oxide PMOS transistors set the high pass cutoff frequency below 1 Hz. AC, noise, and stability simulation tests were performed and then the layout implementation was made. The full chip tape-out is scheduled for July 7th.
| 2026 | |
|
Preamplifiers Brain-computer interfaces Analog integrated circuits Biomedical instruments Preamplificadores Interfaces cerebro-computadora Circuitos integrados analógicos Instrumentos biomédicos Memoria de grado (Ingeniería en electrónica) |
|
| Universidad Católica del Uruguay | |
| LIBERI | |
| https://hdl.handle.net/10895/7570 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución – No Comercial – Sin Derivadas (CC BY-NC-ND 4.0) |
| _version_ | 1878474500041867264 |
|---|---|
| author | González, Ismael |
| author_facet | González, Ismael |
| author_role | author |
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| bitstream.checksumAlgorithm.fl_str_mv | MD5 MD5 MD5 MD5 |
| bitstream.url.fl_str_mv | https://liberi.ucu.edu.uy/bitstreams/3273507c-a40f-4555-acf5-96ea3a4f8433/download https://liberi.ucu.edu.uy/bitstreams/8a7a55c8-d60b-444e-8ca1-97fb25147555/download https://liberi.ucu.edu.uy/bitstreams/5af36046-4c90-4f3a-92a9-9fa285eb331c/download https://liberi.ucu.edu.uy/bitstreams/2d165ea8-9389-44dc-bc43-eaa05db8e36e/download |
| collection | LIBERI |
| dc.creator.advisor.none.fl_str_mv | Miguez, Matías Martínez, Natalia Sapriza, Juan |
| dc.creator.none.fl_str_mv | González, Ismael |
| dc.date.accessioned.none.fl_str_mv | 2026-09-15T21:17:37Z |
| dc.date.issued.none.fl_str_mv | 2026-06-02 |
| dc.description.abstract.none.fl_txt_mv | This work presents the design, simulation, and layout of a fully differential low noise preamplifier for intracortical electroencephalography (iEEG) recording, implemented in TSMC 65 nm LP CMOS technology with a 1 V supply voltage. The circuit is intended as the first stage of an Analog Front-End (AFE) for an implantable device that records and transmits the information wirelessly. The AFE must amplify microvolt level neural signals while rejecting large electrode DC offsets, while meeting the provided power and area constraints. After reviewing existing architectures, the design was finally based on a Miller Compensated Capacitive Feedback Network (MCCFN) topology with a two stage operational transconductance amplifier (OTA). Input AC coupling through Metal/Insulator/Metal (MIM) capacitors blocks the DC electrode potential, and pseudo resistors implemented with thick oxide PMOS transistors set the high pass cutoff frequency below 1 Hz. AC, noise, and stability simulation tests were performed and then the layout implementation was made. The full chip tape-out is scheduled for July 7th. |
| dc.format.extent.es.fl_str_mv | 84 p. |
| dc.format.mimetype.none.fl_str_mv | application/pdf |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/10895/7570 |
| dc.language.iso.none.fl_str_mv | en_US |
| dc.publisher.country.none.fl_str_mv | UY |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución – No Comercial – Sin Derivadas (CC BY-NC-ND 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.rights.uri.none.fl_str_mv | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.source.none.fl_str_mv | reponame:LIBERI instname:Universidad Católica del Uruguay instacron:Universidad Católica del Uruguay |
| dc.subject.en.fl_str_mv | Preamplifiers Brain-computer interfaces Analog integrated circuits Biomedical instruments |
| dc.subject.es.fl_str_mv | Preamplificadores Interfaces cerebro-computadora Circuitos integrados analógicos Instrumentos biomédicos Memoria de grado (Ingeniería en electrónica) |
| dc.title.none.fl_str_mv | Configurable preamplifier for intracortical neural signal recording |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/bachelorThesis |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/acceptedVersion |
| description | This work presents the design, simulation, and layout of a fully differential low noise preamplifier for intracortical electroencephalography (iEEG) recording, implemented in TSMC 65 nm LP CMOS technology with a 1 V supply voltage. The circuit is intended as the first stage of an Analog Front-End (AFE) for an implantable device that records and transmits the information wirelessly. The AFE must amplify microvolt level neural signals while rejecting large electrode DC offsets, while meeting the provided power and area constraints. After reviewing existing architectures, the design was finally based on a Miller Compensated Capacitive Feedback Network (MCCFN) topology with a two stage operational transconductance amplifier (OTA). Input AC coupling through Metal/Insulator/Metal (MIM) capacitors blocks the DC electrode potential, and pseudo resistors implemented with thick oxide PMOS transistors set the high pass cutoff frequency below 1 Hz. AC, noise, and stability simulation tests were performed and then the layout implementation was made. The full chip tape-out is scheduled for July 7th. |
| eu_rights_str_mv | openAccess |
| format | bachelorThesis |
| id | LIBERI_ad620b3f8237847cd03da1ff4ec6bd2a |
| instacron_str | Universidad Católica del Uruguay |
| institution | Universidad Católica del Uruguay |
| instname_str | Universidad Católica del Uruguay |
| language_invalid_str_mv | en_US |
| network_acronym_str | LIBERI |
| network_name_str | LIBERI |
| oai_identifier_str | oai:liberi.ucu.edu.uy:10895/7570 |
| publishDate | 2026 |
| reponame_str | LIBERI |
| repository.mail.fl_str_mv | franco.pertusso@ucu.edu.uy |
| repository.name.fl_str_mv | LIBERI - Universidad Católica del Uruguay |
| repository_id_str | 10342 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución – No Comercial – Sin Derivadas (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| spelling | Licencia Creative Commons Atribución – No Comercial – Sin Derivadas (CC BY-NC-ND 4.0)info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/2026-09-15T21:17:37Z2026-06-02https://hdl.handle.net/10895/7570This work presents the design, simulation, and layout of a fully differential low noise preamplifier for intracortical electroencephalography (iEEG) recording, implemented in TSMC 65 nm LP CMOS technology with a 1 V supply voltage. The circuit is intended as the first stage of an Analog Front-End (AFE) for an implantable device that records and transmits the information wirelessly. The AFE must amplify microvolt level neural signals while rejecting large electrode DC offsets, while meeting the provided power and area constraints. After reviewing existing architectures, the design was finally based on a Miller Compensated Capacitive Feedback Network (MCCFN) topology with a two stage operational transconductance amplifier (OTA). Input AC coupling through Metal/Insulator/Metal (MIM) capacitors blocks the DC electrode potential, and pseudo resistors implemented with thick oxide PMOS transistors set the high pass cutoff frequency below 1 Hz. AC, noise, and stability simulation tests were performed and then the layout implementation was made. The full chip tape-out is scheduled for July 7th.application/pdf84 p.application/pdfen_USPreamplifiersBrain-computer interfacesAnalog integrated circuitsBiomedical instrumentsPreamplificadoresInterfaces cerebro-computadoraCircuitos integrados analógicosInstrumentos biomédicosMemoria de grado (Ingeniería en electrónica)Configurable preamplifier for intracortical neural signal recordinginfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/acceptedVersionUYreponame:LIBERIinstname:Universidad Católica del Uruguayinstacron:Universidad Católica del UruguayGonzález, IsmaelMiguez, MatíasMartínez, NataliaSapriza, JuanORIGINAL131173.pdfIsmael_González_Entrega_Final_V3.pdfapplication/pdf44753049https://liberi.ucu.edu.uy/bitstreams/3273507c-a40f-4555-acf5-96ea3a4f8433/download63405c7593e29d86459630b5dc12ef11MD51trueAnonymousREADLICENSElicense.txtWritten by org.dspace.content.LicenseUtilstext/plain; charset=utf-81021https://liberi.ucu.edu.uy/bitstreams/8a7a55c8-d60b-444e-8ca1-97fb25147555/download40f5922ee6c15fece1c80fd7406b5becMD52falseAnonymousREADTEXT131173.pdf.txtWritten by FormatFilter org.dspace.app.mediafilter.TikaTextExtractionFilter on 2026-09-16T01:01:15Z (GMT).Extracted texttext/plain88156https://liberi.ucu.edu.uy/bitstreams/5af36046-4c90-4f3a-92a9-9fa285eb331c/download5e9a4b22b13a90309dfaefac39082739MD53falseAnonymousREADTHUMBNAIL131173.pdf.jpgWritten by FormatFilter org.dspace.app.mediafilter.PDFBoxThumbnail on 2026-09-16T01:01:16Z (GMT).Generated Thumbnailimage/jpeg3223https://liberi.ucu.edu.uy/bitstreams/2d165ea8-9389-44dc-bc43-eaa05db8e36e/download9a5b1dd0d378a445c08d62043c5c8b67MD54falseAnonymousREAD10895/75702026-09-16 03:01:16.647https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessopen.accessoai:liberi.ucu.edu.uy:10895/7570https://liberi.ucu.edu.uyInstitucionalhttps://liberi.ucu.edu.uy/Universidadhttps://www.ucu.edu.uy/https://liberi.ucu.edu.uy/server/oaifranco.pertusso@ucu.edu.uyUruguayopendoar:103422026-09-16T01:01:16LIBERI - Universidad Católica del 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 |
| spellingShingle | Configurable preamplifier for intracortical neural signal recording González, Ismael Preamplifiers Brain-computer interfaces Analog integrated circuits Biomedical instruments Preamplificadores Interfaces cerebro-computadora Circuitos integrados analógicos Instrumentos biomédicos Memoria de grado (Ingeniería en electrónica) |
| status_str | publishedVersion |
| title | Configurable preamplifier for intracortical neural signal recording |
| title_full | Configurable preamplifier for intracortical neural signal recording |
| title_fullStr | Configurable preamplifier for intracortical neural signal recording |
| title_full_unstemmed | Configurable preamplifier for intracortical neural signal recording |
| title_short | Configurable preamplifier for intracortical neural signal recording |
| title_sort | Configurable preamplifier for intracortical neural signal recording |
| topic | Preamplifiers Brain-computer interfaces Analog integrated circuits Biomedical instruments Preamplificadores Interfaces cerebro-computadora Circuitos integrados analógicos Instrumentos biomédicos Memoria de grado (Ingeniería en electrónica) |
| url | https://hdl.handle.net/10895/7570 |