Molecular accuracy vs antigenic speed: SARS-CoV-2 testing strategies
Resumen:
The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has hit every corner of the world faster than any infectious disease ever known. In this context, rapid and accurate testing of positive cases are essential to follow the test-trace-isolate strategy (TETRIS), which has proven to be a key approach to constrain viral spread. Here, we discuss how to interpret and combine molecular or/and antigen-based detection methods for SARS-CoV-2 as well as when they should be used. Their application can be cleverly designed as an algorithm to prevent viral dissemination according to distinct epidemiological contexts within surveillance programs.
| 2021 | |
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Agencia Nacional de Investigación e Innovación FOCEM - Fondo para la Convergencia Estructural del Mercosur Ambassade de France à Montevideo |
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SARS-CoV-2 Testing strategies RT-PCR Antigenic test Ciencias Naturales y Exactas Ciencias Biológicas Virología |
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| Inglés | |
| Institut Pasteur de Montevideo | |
| IPMON en REDI | |
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https://hdl.handle.net/20.500.12381/3466
https://doi.org/10.1016/j.coph.2021.12.006 |
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| Acceso abierto | |
| Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional. (CC BY-NC-ND) |
| Sumario: | The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has hit every corner of the world faster than any infectious disease ever known. In this context, rapid and accurate testing of positive cases are essential to follow the test-trace-isolate strategy (TETRIS), which has proven to be a key approach to constrain viral spread. Here, we discuss how to interpret and combine molecular or/and antigen-based detection methods for SARS-CoV-2 as well as when they should be used. Their application can be cleverly designed as an algorithm to prevent viral dissemination according to distinct epidemiological contexts within surveillance programs. |
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