ABSTRACT.The growth of demand of organic products has increased the interest of growers all around the World. To reach a sustainable organic production system, growers have to go through a long and difficult process. Eighty-one successful organic production systems in the Southern Cone of America were evaluated regarding management practices, such as disease control, soil fertility, and biodiversity management. The aim of the study was to determine associations between production techniques, farmer training, experience in organic agriculture, yields obtained, and the contribution of organic production to the profitability of farmers. A multivariate analysis was performed to characterize the variability between systems, correlate the management variables and explain economic sustainability. The economic sustainability of farmers was highly correlated with self-production of fungicides and insecticides, use of permitted commercial fertilizers, organic matter application, the use of natural enemies, commercially permitted fungicides and insecticides and the implementation of preventive practices for disease management. Pest monitoring correlated significantly with farmer training and sustainable practices implementation. Farmer?s perception on the importance of crop diversity in organic production correlated with the importance of external inputs independence, green manure, cover crop, and the experience of farmers in organic production. Farmers who implemented more management practices had yield losses below 20% of total production and a gross margin of organic farming of more than 1.5 times the minimum wage of the country than farmers that implemented few or no management practices.Copyright © Canadian Center of Science and Education