Certain animal species become pests or turn invasive, conspiring against other species, the environment, biodiversity, food production and public health. Throughout history, humans have developed different strategies to control or eradicate these problems. Through more effective and affordable tools, and more respectful to the environment and harmless to other species, it will be possible to control more appropriately this kind of threat. CRISPR-based technologies can be applied to achieve this goal by controlling pests that threaten food supply in a growing world population, or preserving ecosystems affected by invasive species in islands and other particular environments. And most importantly, without adversely affecting - and even improving - the global effort focused on the One Health approach. Copyright (c) 2022 Agrociencia Uruguay