Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa.
Resumen:
ABSTRACT.- Heme and iron metabolic pathways are highly intertwined, both compounds being essential for key biological processes, yet becoming toxic if overabundant.Their concentrations are exquisitely regulated, including via dedicated two-component systems (TCSs) that sense signals and regulate adaptive responses.HemKR is a TCS present in both saprophytic and pathogenic Leptospira species, involved in the control of heme metabolism.However, the molecular means by which HemKR is switched on/off in a signal-dependent way, are still unknown.Moreover, a comprehensive list of HemKR-regulated genes, potentially overlapped with iron-responsive targets, is also missing. © 2024 Imelio et al.
| 2024 | |
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Leptospira Bacterial Proteins RNA extraction RNA sequence UNIDAD MIXTA PASTEUR + INIA |
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| Inglés | |
| Instituto Nacional de Investigación Agropecuaria | |
| AINFO | |
| https://ainfo.inia.uy/consulta/busca?b=pc&id=64902&biblioteca=vazio&busca=64902&qFacets=64902 | |
| Acceso abierto |
