Single Nucleotide Polymorphisms and Dental Fluorosis: A Systematic Review
- Autor(es):
- González Casamada, Carlos ; Nevarez Rascón, Martina ; Nevarez Rascón, Alfredo ; González Galván, María ; Isiordia Espinoza, Mario Alberto ; Bologna Molina, Ronell Eduardo ; Sánchez Pérez, Leonor ; Molina Frechero, Nelly
- Tipo:
- Artículo
- Versión:
- Publicado
- Resumen:
-
Genetic factors contribute to susceptibility and resistance to fluoride exposure. The aim of this systematic review was to identify alleles/genotypes of single nucleotide polymorphisms (SNPs) associated with dental fluorosis (DF) and to identify them as protective or risk factors. PubMed, ScienceDirect, Cochrane Library, Scopus and Web of Science were searched for articles; the last search was performed in August 2022. Human studies that analyzed the relationship between SNPs and DF published in English were included; systematic reviews and meta‐analyseswere excluded. Methodological quality was graded using the Joanna Briggs Institute checklist and risk of bias was assessed using the Cochrane Collaboration’s tool. Eighteen articles were included, 44% of which showed high methodological quality and data from 5,625 participants aged 6 to 75 years were analyzed. The SNPs COL1A2, ESR2, DLX1, DLX2, AMBN, TUFT1, TFIP11, miRNA17, and SOD2 were considered risk factors, and ESR1, MMP20, and ENAM were considered protective factors. In conclusion, there are alleles and genotypes of different single nucleotide polymorphisms involved in increasing or decreasing the risk of developing dental fluorosis.
- Año:
- 2022
- Idioma:
- Inglés
- Temas:
- Polymorphism
Dental fluorosis
Gene
POLIMORFISMO DE NUCLEOTIDO SIMPLE
FLUOROSIS DENTAL
- Institución:
- Universidad de la República
- Repositorio:
- COLIBRI
- Enlace(s):
- https://hdl.handle.net/20.500.12008/34741
- Nivel de acceso:
- Acceso abierto