Organocatalytic synthesis and Anti-Trypanosomal activity evaluation of L-Pentofuranose-Mimetic iminosugars
Resumen:
A series of L-lyxo and L-xylo- pentofuranose-mimetic iminosugars and derivatives were efficiently synthesized in a stereoselective manner, through a concise strategy which involves an organocatalyzed Mannich reaction of an imine and a protected dioxanone as key step, using D-proline as catalyst. A preliminary evaluation of their activity as potential anti-trypanosomal agents was studied. One of the synthesized compounds showed an interesting activity against bloodstream Trypanosoma brucei brucei (EC,)=3.8 + 1.0 1M).
| 2022 | |
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CARBOHIDRATOS INMINOAZUCAR TRYPANOSOMA BRUCEI REACCION DE MANNICH ORGANOCATALISIS |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/36737 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
