The Dom Feliciano Belt of southern Brazil and Uruguay represents part of a larger Neoproterozoic orogenic system formed during the amalgamation of Western Gondwana. The hinterland and foreland domains in parts of the belt preserve deformation structures and metamorphic assemblages that developed during early crustal thickening from c. 650 Ma. However, the metamorphic history of the southern foreland, in Uruguay, and its relationship with the hinterland, is not so well understood. We show that metamorphism in the southern hinterland is characterized by near-isothermal decompression from ~10 kbar (~770°C) down to ~6 kbar, reflecting exhumation from depths of ~40 km during convergent thrusting and crustal thickening. This metamorphic event and associated magmatism is constrained by garnet Lu–Hf and zircon U–Pb dating to c. 655–640 Ma, supporting age and P–T constraints from previous studies. In contrast, prograde metamorphism in the foreland supracrustal rocks reached maximum lower-amphibolite facies conditions (~6–7 kbar and ~550–570°C) and is constrained by garnet Lu–Hf dating to 582 ± 23 Ma. An exposed sheet of imbricated foreland basement rocks reached partial melting at upper-amphibolite facies conditions, and metamorphism is similarly constrained to c. 585–570 Ma by monazite U–Pb dating. The data indicate that metamorphism in the foreland occurred during a sinistral transpressional event c. 55–85 Ma after the start of crustal thickening recorded in the hinterland, whereby strain partitioning during sinistral transpression led to imbrication in the foreland and oblique thrusting of the basement over more distal supracrustal rocks. This event is coeval with transpressional deformation in the Kaoko and Gariep belts, indicating a distinct two-stage tectonic history driven by the three-way convergence between the Congo, Kalahari, and South American cratons.