Conjugation Mechanism for Pneumococcal Glycoconjugate Vaccines: Classic and Emerging Methods
Resumen:
Licensed glycoconjugate vaccines are generally prepared using native or sized polysaccha rides coupled to a carrier protein through random linkages along the polysaccharide chain. These polysaccharides must be chemically modified before covalent linking to a carrier protein in order to obtain a more defined polysaccharide structure that leads to a more rational design and safer vaccines. There are classic and new methods for site-selective glycopolysaccharide conjugation, either chemical or enzymatic modification of the polysaccharide length or of specific amino acid residues of the protein carrier. Here, we discuss the state of the art and the advancement of conjugation of S. pneumoniae glycoconjugate vaccines based on pneumococcal capsular polysaccharides to improve existing vaccines.
| 2022 | |
| Programa de Desarrollo de las Ciencias Básicas (PEDEClBA) | |
|
pneumococcus vaccine glycoconjugate vaccines protein carbohydrate conjugation reductive amination CDAP |
|
| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/56072 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| _version_ | 1877555272315043840 |
|---|---|
| author | Morais, Victor |
| author2 | Suarez, Norma |
| author2_role | author |
| author_facet | Morais, Victor Suarez, Norma |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Morais Victor, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Desarrollo Biotecnológico Suarez Norma, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Desarrollo Biotecnológico |
| dc.creator.none.fl_str_mv | Morais, Victor Suarez, Norma |
| dc.date.accessioned.none.fl_str_mv | 2026-07-15T15:24:53Z |
| dc.date.available.none.fl_str_mv | 2026-07-15T15:24:53Z |
| dc.date.issued.none.fl_str_mv | 2022 |
| dc.description.abstract.none.fl_txt_mv | Licensed glycoconjugate vaccines are generally prepared using native or sized polysaccha rides coupled to a carrier protein through random linkages along the polysaccharide chain. These polysaccharides must be chemically modified before covalent linking to a carrier protein in order to obtain a more defined polysaccharide structure that leads to a more rational design and safer vaccines. There are classic and new methods for site-selective glycopolysaccharide conjugation, either chemical or enzymatic modification of the polysaccharide length or of specific amino acid residues of the protein carrier. Here, we discuss the state of the art and the advancement of conjugation of S. pneumoniae glycoconjugate vaccines based on pneumococcal capsular polysaccharides to improve existing vaccines. |
| dc.description.sponsorship.none.fl_txt_mv | Programa de Desarrollo de las Ciencias Básicas (PEDEClBA) |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | MORAIS, V., y SUAREZ, N. Conjugation Mechanism for Pneumococcal Glycoconjugate Vaccines: Classic and Emerging Methods. Bioengineering [en línea] 2022, 9. DOI: 10.3390/bioengineering9120774 |
| dc.identifier.doi.none.fl_str_mv | 10.3390/bioengineering9120774 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/56072 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.relation.none.fl_str_mv | Bioengineering. 9, 2022 |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | pneumococcus vaccine glycoconjugate vaccines protein carbohydrate conjugation reductive amination CDAP |
| dc.title.none.fl_str_mv | Conjugation Mechanism for Pneumococcal Glycoconjugate Vaccines: Classic and Emerging Methods |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Licensed glycoconjugate vaccines are generally prepared using native or sized polysaccha rides coupled to a carrier protein through random linkages along the polysaccharide chain. These polysaccharides must be chemically modified before covalent linking to a carrier protein in order to obtain a more defined polysaccharide structure that leads to a more rational design and safer vaccines. There are classic and new methods for site-selective glycopolysaccharide conjugation, either chemical or enzymatic modification of the polysaccharide length or of specific amino acid residues of the protein carrier. Here, we discuss the state of the art and the advancement of conjugation of S. pneumoniae glycoconjugate vaccines based on pneumococcal capsular polysaccharides to improve existing vaccines. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_bcef4dd4d77dc4a96352ca148c330f53 |
| identifier_str_mv | MORAIS, V., y SUAREZ, N. Conjugation Mechanism for Pneumococcal Glycoconjugate Vaccines: Classic and Emerging Methods. Bioengineering [en línea] 2022, 9. DOI: 10.3390/bioengineering9120774 10.3390/bioengineering9120774 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/56072 |
| publishDate | 2022 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | karina.camps@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Morais Victor, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Desarrollo BiotecnológicoSuarez Norma, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Desarrollo Biotecnológico2026-07-15T15:24:53Z2026-07-15T15:24:53Z2022MORAIS, V., y SUAREZ, N. Conjugation Mechanism for Pneumococcal Glycoconjugate Vaccines: Classic and Emerging Methods. Bioengineering [en línea] 2022, 9. DOI: 10.3390/bioengineering9120774https://hdl.handle.net/20.500.12008/5607210.3390/bioengineering9120774Licensed glycoconjugate vaccines are generally prepared using native or sized polysaccha rides coupled to a carrier protein through random linkages along the polysaccharide chain. These polysaccharides must be chemically modified before covalent linking to a carrier protein in order to obtain a more defined polysaccharide structure that leads to a more rational design and safer vaccines. There are classic and new methods for site-selective glycopolysaccharide conjugation, either chemical or enzymatic modification of the polysaccharide length or of specific amino acid residues of the protein carrier. Here, we discuss the state of the art and the advancement of conjugation of S. pneumoniae glycoconjugate vaccines based on pneumococcal capsular polysaccharides to improve existing vaccines.Submitted by Haller Mariana (mhaller@higiene.edu.uy) on 2026-07-14T20:12:23Z No. of bitstreams: 2 license_rdf: 25630 bytes, checksum: e7132498e7c1fe99f7096667baa99b25 (MD5) Conjugation Mechanism for Pneumococcal Glycoconjugate.pdf: 1146420 bytes, checksum: 34f88328b961d7d085e087d327d5bf43 (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2026-07-15T15:24:53Z (GMT). No. of bitstreams: 2 license_rdf: 25630 bytes, checksum: e7132498e7c1fe99f7096667baa99b25 (MD5) Conjugation Mechanism for Pneumococcal Glycoconjugate.pdf: 1146420 bytes, checksum: 34f88328b961d7d085e087d327d5bf43 (MD5) Previous issue date: 2022Programa de Desarrollo de las Ciencias Básicas (PEDEClBA)application/pdfenengBioengineering. 9, 2022Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. 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- Universidad de la Repúblicafalse |
| spellingShingle | Conjugation Mechanism for Pneumococcal Glycoconjugate Vaccines: Classic and Emerging Methods Morais, Victor pneumococcus vaccine glycoconjugate vaccines protein carbohydrate conjugation reductive amination CDAP |
| status_str | publishedVersion |
| title | Conjugation Mechanism for Pneumococcal Glycoconjugate Vaccines: Classic and Emerging Methods |
| title_full | Conjugation Mechanism for Pneumococcal Glycoconjugate Vaccines: Classic and Emerging Methods |
| title_fullStr | Conjugation Mechanism for Pneumococcal Glycoconjugate Vaccines: Classic and Emerging Methods |
| title_full_unstemmed | Conjugation Mechanism for Pneumococcal Glycoconjugate Vaccines: Classic and Emerging Methods |
| title_short | Conjugation Mechanism for Pneumococcal Glycoconjugate Vaccines: Classic and Emerging Methods |
| title_sort | Conjugation Mechanism for Pneumococcal Glycoconjugate Vaccines: Classic and Emerging Methods |
| topic | pneumococcus vaccine glycoconjugate vaccines protein carbohydrate conjugation reductive amination CDAP |
| url | https://hdl.handle.net/20.500.12008/56072 |
