Conjugation Mechanism for Pneumococcal Glycoconjugate Vaccines: Classic and Emerging Methods
Resumen:
Licensed glycoconjugate vaccines are generally prepared using native or sized polysaccha rides coupled to a carrier protein through random linkages along the polysaccharide chain. These polysaccharides must be chemically modified before covalent linking to a carrier protein in order to obtain a more defined polysaccharide structure that leads to a more rational design and safer vaccines. There are classic and new methods for site-selective glycopolysaccharide conjugation, either chemical or enzymatic modification of the polysaccharide length or of specific amino acid residues of the protein carrier. Here, we discuss the state of the art and the advancement of conjugation of S. pneumoniae glycoconjugate vaccines based on pneumococcal capsular polysaccharides to improve existing vaccines.
| 2022 | |
| Programa de Desarrollo de las Ciencias Básicas (PEDEClBA) | |
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pneumococcus vaccine glycoconjugate vaccines protein carbohydrate conjugation reductive amination CDAP |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/56072 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
