Differences in E-Cadherin and Syndecan-1 Expression in Different Types of Ameloblastomas
- Autor(es):
- Carreón Burciaga, Ramon Gil ; González González, Rogelio ; Molina Frechero, Nelly ; López Verdín, Sandra ; Pereira Prado, Vanesa ; Bologna Molina, Ronell
- Tipo:
- Artículo
- Versión:
- Publicado
- Resumen:
-
Ameloblastomas are a group of benign, locally aggressive, recurrent tumors characterized by their slow and infiltrative growth. ECadherin and syndecan-1 are cell adhesion molecules related to the behavior of various tumors, including ameloblastomas. Ninetynine ameloblastoma samples were studied; the expression of E-cadherin and syndecan-1 were evaluated by immunohistochemistry. E-Cadherin and epithelial syndecan-1 were more highly expressed in intraluminal/luminal unicystic ameloblastom a than in mural unicystic ameloblastoma and solid/multicystic ameloblastoma, whereas the stromal expression of syndecan-1 was higher in mural unicystic ameloblastoma and solid/multicystic ameloblastoma. Synchronicity was observed between E-cadherin and epithelial syndecan-1; the expression was correlated with intensity in all cases. There was a strong association between expression and tumor size and recurrence. The evaluation of the expression of E-cadherin and syndecan-1 are important for determining the potential aggressiveness of ameloblastoma variants. Future studies are required to understand how the expression of these markers is related to tumor aggressiveness.
- Año:
- 2018
- Idioma:
- Inglés
- Temas:
- AMELOBLASTOMA
SINDECANO-1
CADHERINAS
- Institución:
- Universidad de la República
- Repositorio:
- COLIBRI
- Enlace(s):
- https://hdl.handle.net/20.500.12008/31446
- Nivel de acceso:
- Acceso abierto
