Development and evaluation of a 99mTc(V)-nitrido complex derived from estradiol for breast cancer imaging
Resumen:
Estrogen receptors are overexpressed in 70% of breast cancer and identification of their presence is important to select the appropriate treatment. This work proposes the preparation and evaluation of an estradiol derived as potential ER imaging agent. Ethinylestradiol was derivatized to introduce a dithiocarbamate function for Tc coordination. Labeling was achieved through the formation of a symmetric Tc(V)-nitrido complex with a radiochemical purity (RCP) > 95%. Physicochemical evaluation, cell uptake, biodistribution in normal animals and in nude mice bearing induced ER + breast tumors showed promising results.
| 2019 | |
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Estrogen receptors Technetium Radiopharmaceuticals Nitrido complexes |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
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https://hdl.handle.net/20.500.12008/26465
https://doi.org/10.1016/j.apradiso.2019.108854 |
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| Acceso abierto | |
| Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
