Design, Synthesis and Biological Characterization of Potential Antiatherogenic Nitric Oxide Releasing-Tocopherol Analogs.

López, Gloria V. - Batthyány, Carlos - Blanco, Fabiana - Botti, Horacio - Trostchansky, Andrés - Migliaro, Eduardo - Radi, Rafael - González, Mercedes - Cerecetto, Hugo

Resumen:

Synthesis and biological characterization of a series of tocopherol analogs with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties and antiplatelet activity. They were also capable to prevent LDL oxidation.


Detalles Bibliográficos
2005
Inglés
Universidad de la República
COLIBRI
https://hdl.handle.net/20.500.12008/22118
Acceso abierto
Licencia Creative Commons Atribución – No Comercial – Sin Derivadas (CC BY-NC-ND 4.0)
_version_ 1807523183855665152
author López, Gloria V.
author2 Batthyány, Carlos
Blanco, Fabiana
Botti, Horacio
Trostchansky, Andrés
Migliaro, Eduardo
Radi, Rafael
González, Mercedes
Cerecetto, Hugo
author2_role author
author
author
author
author
author
author
author
author_facet López, Gloria V.
Batthyány, Carlos
Blanco, Fabiana
Botti, Horacio
Trostchansky, Andrés
Migliaro, Eduardo
Radi, Rafael
González, Mercedes
Cerecetto, Hugo
author_role author
bitstream.checksum.fl_str_mv 6429389a7df7277b72b7924fdc7d47a9
a006180e3f5b2ad0b88185d14284c0e0
c160655373669e9e820be72396ec31f1
9da0b6dfac957114c6a7714714b86306
927a722ddca53906a5ee93beda2ef01f
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
MD5
bitstream.url.fl_str_mv http://localhost:8080/xmlui/bitstream/20.500.12008/22118/5/license.txt
http://localhost:8080/xmlui/bitstream/20.500.12008/22118/2/license_url
http://localhost:8080/xmlui/bitstream/20.500.12008/22118/3/license_text
http://localhost:8080/xmlui/bitstream/20.500.12008/22118/4/license_rdf
http://localhost:8080/xmlui/bitstream/20.500.12008/22118/1/BMC_versioncorregida_2referatos%282%29.doc
collection COLIBRI
dc.contributor.filiacion.none.fl_str_mv López Gloria V.
Batthyány Carlos
Blanco Fabiana
Botti Horacio
Trostchansky Andrés
Migliaro Eduardo
Radi Rafael
González Mercedes
Cerecetto Hugo
dc.creator.none.fl_str_mv López, Gloria V.
Batthyány, Carlos
Blanco, Fabiana
Botti, Horacio
Trostchansky, Andrés
Migliaro, Eduardo
Radi, Rafael
González, Mercedes
Cerecetto, Hugo
dc.date.accessioned.none.fl_str_mv 2019-10-11T16:04:01Z
dc.date.available.none.fl_str_mv 2019-10-11T16:04:01Z
dc.date.issued.none.fl_str_mv 2005
dc.description.abstract.none.fl_txt_mv Synthesis and biological characterization of a series of tocopherol analogs with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties and antiplatelet activity. They were also capable to prevent LDL oxidation.
dc.description.none.fl_txt_mv Postprint
dc.format.mimetype.none.fl_str_mv application/pdf
dc.identifier.citation.es.fl_str_mv López, G, Batthyány, C, Blanco, F, y otros. "Design, Synthesis and Biological Characterization of Potential Antiatherogenic Nitric Oxide Releasing-Tocopherol Analogs" [en línea] Postprint de Bioorganic & Medicinal Chemistry, no.13 (2005)
dc.identifier.doi.none.fl_str_mv Doi: 10.1016/j.bmc.2005.05.060
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12008/22118
dc.language.iso.none.fl_str_mv en
eng
dc.publisher.none.fl_str_mv Elsevier
dc.relation.ispartof.none.fl_str_mv Bioorganic & Medicinal Chemistry, no.13 (2005)
dc.rights.license.none.fl_str_mv Licencia Creative Commons Atribución – No Comercial – Sin Derivadas (CC BY-NC-ND 4.0)
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.source.none.fl_str_mv reponame:COLIBRI
instname:Universidad de la República
instacron:Universidad de la República
dc.title.none.fl_str_mv Design, Synthesis and Biological Characterization of Potential Antiatherogenic Nitric Oxide Releasing-Tocopherol Analogs.
dc.type.none.fl_str_mv Artículo
info:eu-repo/semantics/article
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
description Postprint
eu_rights_str_mv openAccess
format article
id COLIBRI_162c04681fe847d1a2c2db8a3b6c9a8b
identifier_str_mv López, G, Batthyány, C, Blanco, F, y otros. "Design, Synthesis and Biological Characterization of Potential Antiatherogenic Nitric Oxide Releasing-Tocopherol Analogs" [en línea] Postprint de Bioorganic & Medicinal Chemistry, no.13 (2005)
Doi: 10.1016/j.bmc.2005.05.060
instacron_str Universidad de la República
institution Universidad de la República
instname_str Universidad de la República
language eng
language_invalid_str_mv en
network_acronym_str COLIBRI
network_name_str COLIBRI
oai_identifier_str oai:colibri.udelar.edu.uy:20.500.12008/22118
publishDate 2005
publisher.none.fl_str_mv Elsevier
reponame_str COLIBRI
repository.mail.fl_str_mv mabel.seroubian@seciu.edu.uy
repository.name.fl_str_mv COLIBRI - Universidad de la República
repository_id_str 4771
rights_invalid_str_mv Licencia Creative Commons Atribución – No Comercial – Sin Derivadas (CC BY-NC-ND 4.0)
spelling López Gloria V.Batthyány CarlosBlanco FabianaBotti HoracioTrostchansky AndrésMigliaro EduardoRadi RafaelGonzález MercedesCerecetto Hugo2019-10-11T16:04:01Z2019-10-11T16:04:01Z2005López, G, Batthyány, C, Blanco, F, y otros. "Design, Synthesis and Biological Characterization of Potential Antiatherogenic Nitric Oxide Releasing-Tocopherol Analogs" [en línea] Postprint de Bioorganic & Medicinal Chemistry, no.13 (2005)https://hdl.handle.net/20.500.12008/22118Doi: 10.1016/j.bmc.2005.05.060PostprintSynthesis and biological characterization of a series of tocopherol analogs with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties and antiplatelet activity. They were also capable to prevent LDL oxidation.Submitted by Luna Fabiana (fabiana.luna@fic.edu.uy) on 2019-10-11T16:04:01Z No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) BMC_versioncorregida_2referatos(2).doc: 756736 bytes, checksum: 927a722ddca53906a5ee93beda2ef01f (MD5)Made available in DSpace on 2019-10-11T16:04:01Z (GMT). No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) BMC_versioncorregida_2referatos(2).doc: 756736 bytes, checksum: 927a722ddca53906a5ee93beda2ef01f (MD5) Previous issue date: 2005application/pdfenengElsevierBioorganic & Medicinal Chemistry, no.13 (2005)Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución – No Comercial – Sin Derivadas (CC BY-NC-ND 4.0)Design, Synthesis and Biological Characterization of Potential Antiatherogenic Nitric Oxide Releasing-Tocopherol Analogs.Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaLópez, Gloria V.Batthyány, CarlosBlanco, FabianaBotti, HoracioTrostchansky, AndrésMigliaro, EduardoRadi, RafaelGonzález, MercedesCerecetto, HugoLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/22118/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-850http://localhost:8080/xmlui/bitstream/20.500.12008/22118/2/license_urla006180e3f5b2ad0b88185d14284c0e0MD52license_textlicense_texttext/html; charset=utf-838518http://localhost:8080/xmlui/bitstream/20.500.12008/22118/3/license_textc160655373669e9e820be72396ec31f1MD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-823148http://localhost:8080/xmlui/bitstream/20.500.12008/22118/4/license_rdf9da0b6dfac957114c6a7714714b86306MD54ORIGINALBMC_versioncorregida_2referatos(2).docBMC_versioncorregida_2referatos(2).docapplication/msword756736http://localhost:8080/xmlui/bitstream/20.500.12008/22118/1/BMC_versioncorregida_2referatos%282%29.doc927a722ddca53906a5ee93beda2ef01fMD5120.500.12008/221182021-03-10 11:20:02.003oai:colibri.udelar.edu.uy:20.500.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Universidadhttps://udelar.edu.uy/https://www.colibri.udelar.edu.uy/oai/requestmabel.seroubian@seciu.edu.uyUruguayopendoar:47712024-07-25T14:44:31.693548COLIBRI - Universidad de la Repúblicafalse
spellingShingle Design, Synthesis and Biological Characterization of Potential Antiatherogenic Nitric Oxide Releasing-Tocopherol Analogs.
López, Gloria V.
status_str publishedVersion
title Design, Synthesis and Biological Characterization of Potential Antiatherogenic Nitric Oxide Releasing-Tocopherol Analogs.
title_full Design, Synthesis and Biological Characterization of Potential Antiatherogenic Nitric Oxide Releasing-Tocopherol Analogs.
title_fullStr Design, Synthesis and Biological Characterization of Potential Antiatherogenic Nitric Oxide Releasing-Tocopherol Analogs.
title_full_unstemmed Design, Synthesis and Biological Characterization of Potential Antiatherogenic Nitric Oxide Releasing-Tocopherol Analogs.
title_short Design, Synthesis and Biological Characterization of Potential Antiatherogenic Nitric Oxide Releasing-Tocopherol Analogs.
title_sort Design, Synthesis and Biological Characterization of Potential Antiatherogenic Nitric Oxide Releasing-Tocopherol Analogs.
url https://hdl.handle.net/20.500.12008/22118

Resultados similares