Design, Synthesis and Biological Characterization of Potential Antiatherogenic Nitric Oxide Releasing-Tocopherol Analogs.

López, Gloria V. - Batthyány, Carlos - Blanco, Fabiana - Botti, Horacio - Trostchansky, Andrés - Migliaro, Eduardo - Radi, Rafael - González, Mercedes - Cerecetto, Hugo

Resumen:

Synthesis and biological characterization of a series of tocopherol analogs with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties and antiplatelet activity. They were also capable to prevent LDL oxidation.


Detalles Bibliográficos
2005
Inglés
Universidad de la República
COLIBRI
https://hdl.handle.net/20.500.12008/22118
Acceso abierto
Licencia Creative Commons Atribución – No Comercial – Sin Derivadas (CC BY-NC-ND 4.0)