Abstract: Patient safety has become a priority for the health system, including dentistry. Several studies showed that health care meant to improve people’s health is an important source of isease. Good clinical practices aim to maximize effectiveness and therapeutic compliance, minimize risks and costs, respecting the patient’s choice from generic drugs, also from the moment of prescribing, the supervision of drug-related events must be taken into account, not only on the patient but also in the environment. Pharmacovigilance and pharmacoecovigilance have to be conceived as a clinical practice in dentistry. There is no established culture of drug induced reaction reports by dentists in Uruguay, and awareness of environmental care is incipient. The pharmacy of faculty of dentistry, (Universidad de la República), an institutional project that has been developed since 2006, is in a transformation process. The pharmacovigilance dentistry Node is in full development. The toxicovigilance and pharmacoecovigilance activities are recent. The general aim of this project was to establish the pharmacovigilance, toxicovigilance and pharmacoecovigilance clinical practice in dentistry. The widespread use of cosmetic as toothpastes, or mouth rinses, drugs and dental materials, as well as exposure to chemical contaminants through the population’s living habits and the environmental damage caused by drug wastes requires comprehensive and up-to-date information to establish rational strategies. Abstract: Patient safety has become a priority for the health system, including dentistry. Several studies showed that health care meant to improve people’s health is an important source of isease. Good clinical practices aim to maximize effectiveness and therapeutic compliance, minimize risks and costs, respecting the patient’s choice from generic drugs, also from the moment of prescribing, the supervision of drug-related events must be taken into account, not only on the patient but also in the environment. Pharmacovigilance and pharmacoecovigilance have to be conceived as a clinical practice in dentistry. There is no established culture of drug induced reaction reports by dentists in Uruguay, and awareness of environmental care is incipient. The pharmacy of faculty of dentistry, (Universidad de la República), an institutional project that has been developed since 2006, is in a transformation process. The pharmacovigilance dentistry Node is in full development. The toxicovigilance and pharmacoecovigilance activities are recent. The general aim of this project was to establish the pharmacovigilance, toxicovigilance and pharmacoecovigilance clinical practice in dentistry. The widespread use of cosmetic as toothpastes, or mouth rinses, drugs and dental materials, as well as exposure to chemical contaminants through the population’s living habits and the environmental damage caused by drug wastes requires comprehensive and up-to-date information to establish rational strategies. Abstract: Patient safety has become a priority for the health system, including dentistry. Several studies showed that health care meant to improve people’s health is an important source of isease. Good clinical practices aim to maximize effectiveness and therapeutic compliance, minimize risks and costs, respecting the patient’s choice from generic drugs, also from the moment of prescribing, the supervision of drug-related events must be taken into account, not only on the patient but also in the environment. Pharmacovigilance and pharmacoecovigilance have to be conceived as a clinical practice in dentistry. There is no established culture of drug induced reaction reports by dentists in Uruguay, and awareness of environmental care is incipient. The pharmacy of faculty of dentistry, (Universidad de la República), an institutional project that has been developed since 2006, is in a transformation process. The pharmacovigilance dentistry Node is in full development. The toxicovigilance and pharmacoecovigilance activities are recent. The general aim of this project was to establish the pharmacovigilance, toxicovigilance and pharmacoecovigilance clinical practice in dentistry. The widespread use of cosmetic as toothpastes, or mouth rinses, drugs and dental materials, as well as exposure to chemical contaminants through the population’s living habits and the environmental damage caused by drug wastes requires comprehensive and up-to-date information to establish rational strategies.