Orosomucoid-1 Expression in Ameloblastoma Variants
- Autor(es):
- García Muñoz, Alejandro ; Bologna Molina, Ronell ; Rodríguez, Mario A. ; Liceága-Reyes, Rodrigo ; Farfán Morales, José Eduardo ; Aranda-Romo, Saray ; Molina Frechero, Nelly ; González González, Rogelio
- Tipo:
- Artículo
- Versión:
- Publicado
- Resumen:
-
Odontogenic tumors constitute a group of heterogeneous lesions of benign and malignant neoplasms with variable aggressiveness. Ameloblastomas are a group of benign but locally invasive neoplasms that occur in the jaws and are derived from epithelial elements of the tooth-forming apparatus. We previously described orosomucoid-1 protein expression in odontogenic myxomas. However, whether orosomucoid-1 is expressed in other odontogenic tumors remains unknown. Since orosomucoid-1 belongs to a group of acute-phase proteins and has many functions in health and disease, we identified and analyzed orosomucoid-1 expression in ameloblastoma variants and ameloblastic carcinoma using western blot and immunohistochemical techniques. Thirty cases of ameloblastoma were analyzed for orsomucoid-1; five specimens were fresh for western blot study (four benign ameloblastomas and one ameloblastic carcinoma), and 25 cases of benign ameloblastoma for immunohistochemical assays. Orosomucoid-1 was widely expressed in each tumor variant analyzed in this study, and differential orosomucoid-1 expression was observed between benign and malignant tumor. Orosomucoid-1 may play an important role in the behavior of ameloblastomas and influence the biology and development of the variants of this tumor.
- Año:
- 2016
- Idioma:
- Inglés
- Temas:
- Orosomucoid-1
Ameloblastoma
Ameloblastic carcinoma
Odontogenic tumors
- Institución:
- Universidad de la República
- Repositorio:
- COLIBRI
- Enlace(s):
- https://hdl.handle.net/20.500.12008/31462
- Nivel de acceso:
- Acceso abierto