Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: A living systematic review
- Autor(es):
- Martins Silveira, Felipe ; Rodrigues Mello, Andre Luiz ; da Silva Fonseca, Laura ; Dos Santos Ferreira, Luise ; Borges Kirschnick, Laura ; Domingues Martins, Manoela ; Frenzel Schuch, Lauren ; Almeida de Arruda, Jose Alcides ; Dantas Soares, Ciro ; De Oliveiras Sales, Alexandre ; Bologna-Molina, Ronell ; Santos-Silva, Alan Roger ; Uchoa Vasconcelos, Ana Carolina
- Tipo:
- Artículo
- Versión:
- Publicado
- Resumen:
-
Objective: This living systematic review aims to integrate the morphological and tissue-based molecular caracterization of oral lesions occurring in individuals infected by COVID-19 (OLICs). Materials and Design: This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Web of Science, Scopus, Ovid, Embase, and LILACS were searched to identify reports on OLICs with morphological and/or tissue-based molecular data. Results: Four studies reporting five cases were included. Three patients were male, and the mean age of the individuals was 47.6 years. The most reported anatomical location was the palate (n = 4), whereas ulcers were the most frequent clinical presentation (n = 3). Histopathologically, all cases revealed cell vacuolization and exocytosis in the epithelial layer. In the mesenchymal layer, inflammatory cell infiltrate and thrombi/microvascular thrombosis were observed in three cases. Immunohistochemical reactions were performed in two cases. Both cases were negative for HHV-1, HHV-2, and CMV. One case revealed positivity for SARS-CoV-2 spike protein. No other molecular tests were found for the characterization of OLIC. Conclusions: The pathological characteristics of OLICs are still unspecific. However, with the ongoing COVID-19 pandemic and well-documented new cases, whether OLICs are due to coinfections or has a primary origin can be determined.
- Año:
- 2022
- Idioma:
- Inglés
- Temas:
- COVID-19
Oral pathology
Molecular pathology Pandemics
SARS-CoV-2
- Institución:
- Universidad de la República
- Repositorio:
- COLIBRI
- Enlace(s):
- https://hdl.handle.net/20.500.12008/30969
https://doi.org/10.1016/j.archoralbio.2022.105374
- Nivel de acceso:
- Acceso abierto