Next-Generation Whole-Cell Pneumococcal Vaccine
Resumen:
Streptococcus pneumoniae remains a major public health hazard. Although Pneumococcal Conjugate Vaccines (PCVs) are available and have significantly reduced the rate of invasive pneumococcal diseases, there is still a need for new vaccines with unlimited serotype coverage, long-lasting protection, and lower cost to be developed. One of the most promising candidates is the Whole-Cell Pneumococcal Vaccine (WCV). The new generation of whole-cell vaccines is based on an unencapsulated serotype that allows the expression of many bacterial antigens at a lower cost than a recombinant vaccine. These vaccines have been extensively studied, are currently in human trial phase 1/2, and seem to be the best treatment choice for pneumococcal diseases, especially for developing countries.
| 2019 | |
| Programa de Desarrollo de las Ciencias Básicas (PEDEClBA) | |
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Streptococcus pneumoniae whole-cell vaccine RM200 virulence factors |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/56091 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
