Infusion chemotherapy in malignant melanoma
Quimioterapia por perfusión en el melanoma maligno
Resumen:
A description is given of the perfusion method with Phenyl-Alanine-Mustard, in the treatment of malignant melanomas of the extremities. An analysis was made of the results obtained in 20 cases treated. Attention was called to the anatómopathological modifications which were observed, such as, reduction in the size of tt¡mor, necrosis of same, cell lysis, liberation of melanotic pigments, etc. 'I'he e:f'fect of the drug appears to be more significant in pigmented than in amelanotic tumors. In no case was total disappearance of the tumor achieved and, consequently, this method is considered as complementaryto surgery.
Se describe el método de la perfusión en el miembro aislado con la Fenil-Alanina-Mostaza en el tratamiento de los melanomas malignos de los miembros,analizándose los resultados obtenidos en 20 procedimientos realizados. Destacamos las modificaciones anatomopatológicas observadas, tales como: disminución en el tamaño deltumor, necrosis del mismo, lisis celulares, liberación d<c pigmentos melánicos, etc. La acción de la droga parece ser mayor en los tumores pigmentados que enlo
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melanoma quimioterapia melanoma chemotherapy |
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Español | |
Sociedad de Cirugía del Uruguay | |
Revista Cirugía del Uruguay | |
https://revista.scu.org.uy/index.php/cir_urug/article/view/2682 | |
Acceso abierto |
Sumario: | A description is given of the perfusion method with Phenyl-Alanine-Mustard, in the treatment of malignant melanomas of the extremities. An analysis was made of the results obtained in 20 cases treated. Attention was called to the anatómopathological modifications which were observed, such as, reduction in the size of tt¡mor, necrosis of same, cell lysis, liberation of melanotic pigments, etc. 'I'he e:f'fect of the drug appears to be more significant in pigmented than in amelanotic tumors. In no case was total disappearance of the tumor achieved and, consequently, this method is considered as complementaryto surgery. |
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