Mortality factors in acute septic cholangitis
Factores de mortalidad en las colangitis agudas sépticas
Resumen:
The mortality of acute septic cholangitis (CAS) continues to be high in Uruguay despite its significant decline in recent years. The objective of the present study is to establish the determinants of mortality in patients with CAS; from a retrospective record of 10 years. Sixty-seven patients were studied, 33% entered into septic shock, Klebsiella BLEE developed in 50% of cases and ampicillin sulbactam was empirically indicated in 59% with a mean time of 4 days of biliary drainage. Mortality in the series was 37%. Statistically significant factors for mortality were: age (greater than 65 years), initial shock, male gender, and time interval prior to biliary deobstruction. Statistically significant factors associated with mortality are: age greater than 65 years, initial shock, male sex and time interval before biliary deobstruction. Late degra- vation of the biliary tract and the empirical use of low-efficacy antibiotics are factors associated with an unfavorable outcome. The use of minimally invasive surgical techniques is associated with better survival.
La mortalidad de la colangitis aguda séptica (CAS) continúa siendo elevada en el Uruguay a pesar de su descenso significativo en los últimos años. El objetivo del presente trabajo es establecer los factores determinantes de la mortalidad en pacientes con CAS; a partir de un registro retrospectivo de 10 años. Se estudiaron 67 pacientes, 33% ingresaron en shock séptico, Klebsiella BLEE se desarrolló en un 50% de los casos y ampicilina / sulbactam fue indicado empíricamente en el 59%, con un tiempo medio de desobstrucción biliar de 4 días. La mortalidad de la serie fue de 37%. Se establecen como factores estadísticamente significativos de vinculados a la mortalidad: la edad mayor a 65 años, shock inicial, sexo masculino y el intervalo de tiempo a la desobstrucción biliar. La degravitación tardía de la vía biliar y la utilización empírica de antibióticos de baja eficacia, son factores asociados a una evolución desfavorable. La utilización de técnicas quirúrgicas mínimamente invasivas se asocian con mejor sobrevida.
2019 | |
Colangitis sepsis mortalidad Cholangitis sepsis mortality |
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Español | |
Sociedad de Cirugía del Uruguay | |
Revista Cirugía del Uruguay | |
https://revista.scu.org.uy/index.php/cir_urug/article/view/20 | |
Acceso abierto |
Sumario: | The mortality of acute septic cholangitis (CAS) continues to be high in Uruguay despite its significant decline in recent years. The objective of the present study is to establish the determinants of mortality in patients with CAS; from a retrospective record of 10 years. Sixty-seven patients were studied, 33% entered into septic shock, Klebsiella BLEE developed in 50% of cases and ampicillin sulbactam was empirically indicated in 59% with a mean time of 4 days of biliary drainage. Mortality in the series was 37%. Statistically significant factors for mortality were: age (greater than 65 years), initial shock, male gender, and time interval prior to biliary deobstruction. Statistically significant factors associated with mortality are: age greater than 65 years, initial shock, male sex and time interval before biliary deobstruction. Late degra- vation of the biliary tract and the empirical use of low-efficacy antibiotics are factors associated with an unfavorable outcome. The use of minimally invasive surgical techniques is associated with better survival. |
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