Experimental model of pancreatitis in the dog
Modelo experimental de pancreatitis en el perro
Resumen:
The authors report a simple procedure to produce acute edematous pancreatitis experimentally, by injecting bile into the pancreatic duct, without ligating it, in a series of 10 dogs. The results were homogeneous from the clinical and pathological standpoints, as well as for the labora tory findings ( increase of the level of amylase both in blood and in the peritoneal exudate).The pressure at which the bile is injected must be measured and it must be from 9 to 10 cm of water. Provided this pressure is constant, the homogeneity of the results thus obtained make this procedure a proper experimental mcdel fer the assessment of different therapeutic procedures.
Se presenta un procedimiento sencillo de producción experimental de pancreatitis aguda edematosa, por inyección de bilis dentro del canal de Wirsung, sin ligadura del mismo, realizado en una serie de 10 perros. Los resultados fueron homogéneos desde el punto de vista clínico, de laboratorio (ascenso de niveles de amilasemia y amilasa en exudado peritoneal) y anatomopatológico. Cuidando que la presión ele inyección de la bilis -que debe medirse- sea constante y de 9 a 10 cm de agua, la homogeneidad de los resultados obtenidos, lo convierten en un modelo experimental adecuado para la valoración de distintos procedimientos terapéuticos.
1975 | |
pancreatitis etiología conductos pancreáticos efecto de las drogas pancreatitis etiology pancreatic ducts drug effects |
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Español | |
Sociedad de Cirugía del Uruguay | |
Revista Cirugía del Uruguay | |
https://revista.scu.org.uy/index.php/cir_urug/article/view/2623 | |
Acceso abierto |
Sumario: | The authors report a simple procedure to produce acute edematous pancreatitis experimentally, by injecting bile into the pancreatic duct, without ligating it, in a series of 10 dogs. The results were homogeneous from the clinical and pathological standpoints, as well as for the labora tory findings ( increase of the level of amylase both in blood and in the peritoneal exudate).The pressure at which the bile is injected must be measured and it must be from 9 to 10 cm of water. Provided this pressure is constant, the homogeneity of the results thus obtained make this procedure a proper experimental mcdel fer the assessment of different therapeutic procedures. |
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