Inflammatory breast cancer Clinical presentation Value of combined treatments

Cáncer inflamatorio de mama Presentación clínica Valor de los tratamientos combinados

Viola Alles, Alberto - Sabini, Graciela - Barrios, Enrique - Musé, Miguel

Resumen:

Over a total of 1152 patients carrying breas/ cancer whowere treated between 1978 and 1988, 41 cases (3,5%)corresponded to the inf/ammatory variety Their agesranged between 26 and 73 years; 15 (63,5 %) werefound in postmenopausica/ women. From the clinicalpoint of view, in 34, 1 % of the cases the disease waslimited to the breast exclusive/y; 48, 7% presentedregional invasion of nades and the remainig 17%presented disseminated disease. lnitial treatmentconsisted of 3-4 chemotherapy cycles of the FAC typeexcept in the case of elderly patients who a/so receivedCMF association. Al/ of them were la ter radiated withdoses of 5000-6000 cGy over breas/ and nadeterritories. Treatment ended with 6 to 8 additionalchemoterapy cycles. None of the patients underwentsurgery. Median survival of the whole population was of22 months (26 far premenopausica/ patients and 15 farthe postmenopausical ones). Recidive percentage roseas 30%, 45% of the localized forms disseminated in theevolution. The authors emphasize the fact that thetherapeutical strategy was based on chemo-radiotherapyassociation; there is a possibility of management withhigh doses of cytostatic agents with or without bonemarrow transplant.


Sobre un total de 1152 pacientes portadoras de cáncerde mama, tratadas en el período 1978-1988, 41 de ellas(3,5%) correspondieron a la variedad inflamatoria.Sus edades estaban comprendidas entre 26 y 73 años;siendo 15 (63,5%) posmenopáusicas.Clínicamente presentaron compromiso mamarioexclusivo 34, 1 %; invasión ganglionar locorregional48, 7% y estaban diseminadas 17% restantes. Eltratamiento inicial se basó en 3-4 ciclos de quimioterapiatipo FAC; salvo en pacientes añosas que recibieron laasociación CMF Todas ellas luego se irradiaron condosis de 5000-6000 cGy sobre mama y territoriosganglionares. Se culminó el tratamiento con 6 a 8 ciclosadicionales de quimioterapia. Ninguna de las pacientesfue sometida a cirugía. La sobrevida media del total de lapoblación fue de 22 meses, siendo de 26 para laspremenopáusicas y 15 para las posmenopáusicas. Elporcentaje de recidivas llegó al 30%; y 45% de lasformas localizadas se diseminaron durante su evolución.Se destaca que la estrategia terapéutica se basó en laasociación quimio-radioterapia, quedando abierta laposibilidad del manejo de altas dosis de citos/áticos cono sin trasplante de médula ósea.


Detalles Bibliográficos
1995
cáncer de mama
tumores
breast cancer
tumors
Español
Sociedad de Cirugía del Uruguay
Revista Cirugía del Uruguay
https://revista.scu.org.uy/index.php/cir_urug/article/view/4190
Acceso abierto
Resumen:
Sumario:Over a total of 1152 patients carrying breas/ cancer whowere treated between 1978 and 1988, 41 cases (3,5%)corresponded to the inf/ammatory variety Their agesranged between 26 and 73 years; 15 (63,5 %) werefound in postmenopausica/ women. From the clinicalpoint of view, in 34, 1 % of the cases the disease waslimited to the breast exclusive/y; 48, 7% presentedregional invasion of nades and the remainig 17%presented disseminated disease. lnitial treatmentconsisted of 3-4 chemotherapy cycles of the FAC typeexcept in the case of elderly patients who a/so receivedCMF association. Al/ of them were la ter radiated withdoses of 5000-6000 cGy over breas/ and nadeterritories. Treatment ended with 6 to 8 additionalchemoterapy cycles. None of the patients underwentsurgery. Median survival of the whole population was of22 months (26 far premenopausica/ patients and 15 farthe postmenopausical ones). Recidive percentage roseas 30%, 45% of the localized forms disseminated in theevolution. The authors emphasize the fact that thetherapeutical strategy was based on chemo-radiotherapyassociation; there is a possibility of management withhigh doses of cytostatic agents with or without bonemarrow transplant.