This paper aims at studying the status of the current fleet of freight vehicles that travel through Uruguay, following international methodologies for calculating GHG gas emissions to determine the current inventory of gases caused by road freight transport. This inventory acts as a starting point to establish three future scenarios where different alternative powertrain technologies are implemented at different rates, such as battery electric vehicles (BEV) and fuel cell electric vehicles (FCEV). The transition from Euro III regulations into Euro V is also considered for these scenarios. Based on these future scenarios, it is possible to project the levels of future emissions that Uruguay will perceive in a time horizon that reaches the year 2050. This study aims to increase the level of information present in the region on the emissions generated in the road freight transport sector, providing new input to the development of future policies on these issues.