The multifaceted nature of peroxiredoxins in chemical biology
Resumen:
Peroxiredoxins (Prx), thiol-dependent peroxidases, were first identified as H2O2 detoxifiers, and more recently as H2O2 sensors, intermediates in redox-signaling pathways, metabolism modulators, and chaperones. The multifaceted nature of Prx is not only dependent on their peroxidase activity but also strongly associated with specific protein–protein interactions that are being identified, and where the Prx oligomerization dynamics plays a role. Their oxidation by a peroxide substrate forms a sulfenic acid that opens a route to channel the redox signal to diverse protein targets. Recent research underscores the importance of different Prx isoforms in the cellular processes behind disease development with potential therapeutic applications.
| 2023 | |
| Agencia Nacional de Investigación e Innovación | |
|
Peroxirredoxina Ciencias Naturales y Exactas Ciencias Biológicas |
|
| Inglés | |
| Agencia Nacional de Investigación e Innovación | |
| REDI | |
| https://hdl.handle.net/20.500.12381/3292 | |
| Acceso embargado | |
| Reconocimiento-CompartirIgual 4.0 Internacional. (CC BY-SA) |
| _version_ | 1814959258459963392 |
|---|---|
| author | Villar, Sebastián F. |
| author2 | Ferrer-Sueta, Gerardo Denicola, Ana |
| author2_role | author author |
| author_facet | Villar, Sebastián F. Ferrer-Sueta, Gerardo Denicola, Ana |
| author_role | author |
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| bitstream.url.fl_str_mv | https://redi.anii.org.uy/jspui/bitstream/20.500.12381/3292/6/license.txt https://redi.anii.org.uy/jspui/bitstream/20.500.12381/3292/7/Correo%20de%20ANII%20-%20Fwd_%20Share%20your%20article%20%5bCOCHBI_102355%5d%20published%20in%20Current%20Opinion%20in%20Chemical%20Biology.pdf https://redi.anii.org.uy/jspui/bitstream/20.500.12381/3292/5/COCHB%202023%20The%20multifaceted%20nature%20of%20prx.pdf |
| collection | REDI |
| dc.creator.none.fl_str_mv | Villar, Sebastián F. Ferrer-Sueta, Gerardo Denicola, Ana |
| dc.date.accessioned.none.fl_str_mv | 2023-09-28T19:17:04Z |
| dc.date.issued.none.fl_str_mv | 2023-10 |
| dc.description.abstract.none.fl_txt_mv | Peroxiredoxins (Prx), thiol-dependent peroxidases, were first identified as H2O2 detoxifiers, and more recently as H2O2 sensors, intermediates in redox-signaling pathways, metabolism modulators, and chaperones. The multifaceted nature of Prx is not only dependent on their peroxidase activity but also strongly associated with specific protein–protein interactions that are being identified, and where the Prx oligomerization dynamics plays a role. Their oxidation by a peroxide substrate forms a sulfenic acid that opens a route to channel the redox signal to diverse protein targets. Recent research underscores the importance of different Prx isoforms in the cellular processes behind disease development with potential therapeutic applications. |
| dc.description.sponsorship.none.fl_txt_mv | Agencia Nacional de Investigación e Innovación |
| dc.identifier.anii.es.fl_str_mv | FCE_1_2019_1_155969 |
| dc.identifier.doi.none.fl_str_mv | 10.1016/j.cbpa.2023.102355 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12381/3292 |
| dc.language.iso.none.fl_str_mv | eng |
| dc.publisher.es.fl_str_mv | Elsevier |
| dc.rights.*.fl_str_mv | Acceso embargado |
| dc.rights.embargoend.*.fl_str_mv | 2025-06-28 |
| dc.rights.embargoterm.*.fl_str_mv | 2025-06-28 |
| dc.rights.license.none.fl_str_mv | Reconocimiento-CompartirIgual 4.0 Internacional. (CC BY-SA) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/embargoedAccess |
| dc.source.es.fl_str_mv | Current Opinion in Chemical Biology |
| dc.source.none.fl_str_mv | reponame:REDI instname:Agencia Nacional de Investigación e Innovación instacron:Agencia Nacional de Investigación e Innovación |
| dc.subject.anii.none.fl_str_mv | Ciencias Naturales y Exactas Ciencias Biológicas |
| dc.subject.es.fl_str_mv | Peroxirredoxina |
| dc.title.none.fl_str_mv | The multifaceted nature of peroxiredoxins in chemical biology |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.es.fl_str_mv | Publicado |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Peroxiredoxins (Prx), thiol-dependent peroxidases, were first identified as H2O2 detoxifiers, and more recently as H2O2 sensors, intermediates in redox-signaling pathways, metabolism modulators, and chaperones. The multifaceted nature of Prx is not only dependent on their peroxidase activity but also strongly associated with specific protein–protein interactions that are being identified, and where the Prx oligomerization dynamics plays a role. Their oxidation by a peroxide substrate forms a sulfenic acid that opens a route to channel the redox signal to diverse protein targets. Recent research underscores the importance of different Prx isoforms in the cellular processes behind disease development with potential therapeutic applications. |
| eu_rights_str_mv | embargoedAccess |
| format | article |
| id | REDI_9b92a7e68384d741462eb5985aae42a2 |
| identifier_str_mv | FCE_1_2019_1_155969 10.1016/j.cbpa.2023.102355 |
| instacron_str | Agencia Nacional de Investigación e Innovación |
| institution | Agencia Nacional de Investigación e Innovación |
| instname_str | Agencia Nacional de Investigación e Innovación |
| language | eng |
| network_acronym_str | REDI |
| network_name_str | REDI |
| oai_identifier_str | oai:redi.anii.org.uy:20.500.12381/3292 |
| publishDate | 2023 |
| reponame_str | REDI |
| repository.mail.fl_str_mv | jmaldini@anii.org.uy |
| repository.name.fl_str_mv | REDI - Agencia Nacional de Investigación e Innovación |
| repository_id_str | 9421 |
| rights_invalid_str_mv | Reconocimiento-CompartirIgual 4.0 Internacional. (CC BY-SA) Acceso embargado 2025-06-28 |
| spelling | Reconocimiento-CompartirIgual 4.0 Internacional. (CC BY-SA)Acceso embargado2025-06-28La revista ofrece opciones de acceso abierto, pero el costo está más allá de nuestras posibilidades o del financiamiento recibido2025-06-28info:eu-repo/semantics/embargoedAccess2023-09-28T19:17:04Z2023-10https://hdl.handle.net/20.500.12381/3292FCE_1_2019_1_15596910.1016/j.cbpa.2023.102355Peroxiredoxins (Prx), thiol-dependent peroxidases, were first identified as H2O2 detoxifiers, and more recently as H2O2 sensors, intermediates in redox-signaling pathways, metabolism modulators, and chaperones. The multifaceted nature of Prx is not only dependent on their peroxidase activity but also strongly associated with specific protein–protein interactions that are being identified, and where the Prx oligomerization dynamics plays a role. Their oxidation by a peroxide substrate forms a sulfenic acid that opens a route to channel the redox signal to diverse protein targets. Recent research underscores the importance of different Prx isoforms in the cellular processes behind disease development with potential therapeutic applications.Agencia Nacional de Investigación e InnovaciónengElsevierCurrent Opinion in Chemical Biologyreponame:REDIinstname:Agencia Nacional de Investigación e Innovacióninstacron:Agencia Nacional de Investigación e InnovaciónPeroxirredoxinaCiencias Naturales y ExactasCiencias BiológicasThe multifaceted nature of peroxiredoxins in chemical biologyArtículoPublicadoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidad de la República. Facultad de Ciencias//Ciencias Naturales y Exactas/Ciencias Biológicas/Ciencias BiológicasVillar, Sebastián F.Ferrer-Sueta, GerardoDenicola, AnaLICENSElicense.txtlicense.txttext/plain; charset=utf-84967https://redi.anii.org.uy/jspui/bitstream/20.500.12381/3292/6/license.txta4ce09f01b5dd771727aa05c73851623MD56Correo de ANII - Fwd_ Share your article [COCHBI_102355] published in Current Opinion in Chemical Biology.pdfCorreo de ANII - Fwd_ Share your article [COCHBI_102355] published in Current Opinion in Chemical Biology.pdfapplication/pdf257440https://redi.anii.org.uy/jspui/bitstream/20.500.12381/3292/7/Correo%20de%20ANII%20-%20Fwd_%20Share%20your%20article%20%5bCOCHBI_102355%5d%20published%20in%20Current%20Opinion%20in%20Chemical%20Biology.pdfd54149da0756970d164af02cb04e11e4MD57ORIGINALCOCHB 2023 The multifaceted nature of prx.pdfCOCHB 2023 The multifaceted nature of prx.pdfDocumento aceptadoapplication/pdf838859https://redi.anii.org.uy/jspui/bitstream/20.500.12381/3292/5/COCHB%202023%20The%20multifaceted%20nature%20of%20prx.pdf7cedaeded1db84960a512fccfea50703MD5520.500.12381/32922023-09-28 16:17:05.905oai:redi.anii.org.uy:20.500.12381/3292Gobiernohttps://www.anii.org.uy/https://redi.anii.org.uy/oai/requestjmaldini@anii.org.uyUruguayopendoar:94212023-09-28T19:17:05REDI - Agencia Nacional de Investigación e Innovaciónfalse |
| spellingShingle | The multifaceted nature of peroxiredoxins in chemical biology Villar, Sebastián F. Peroxirredoxina Ciencias Naturales y Exactas Ciencias Biológicas |
| status_str | publishedVersion |
| title | The multifaceted nature of peroxiredoxins in chemical biology |
| title_full | The multifaceted nature of peroxiredoxins in chemical biology |
| title_fullStr | The multifaceted nature of peroxiredoxins in chemical biology |
| title_full_unstemmed | The multifaceted nature of peroxiredoxins in chemical biology |
| title_short | The multifaceted nature of peroxiredoxins in chemical biology |
| title_sort | The multifaceted nature of peroxiredoxins in chemical biology |
| topic | Peroxirredoxina Ciencias Naturales y Exactas Ciencias Biológicas |
| url | https://hdl.handle.net/20.500.12381/3292 |
