Even though the interpretation of Free Choice Items such as any has been on debate for more than 50 years (Vendler, 1974, Dayal, 1998, Horn, 2000, etc.), it is relatively more recent in Spanish (Men ́endez-Benito, 2005, Giannakidou and Quer, 2013, among others). Some have analyzed it as a universal quantifier, neither taking its free choiceness into account nor contexts which seem to be problematic for the universal account (see, for instance, Etxepare and Uribe-Etxebarria, 2011). In this article, we defend that cualquier is a universal indeterminate pronoun which involves freedom of choice (as in the original proposal by Vendler, 1974). We will take into account data (taken from https://www.corpusdelespanol.org/web-dial) which has not been properly considered. We will analyze the interaction of negation and cualquier in Rioplantense Spanish in the subject position of negative generic statements, in the object position in negative episodic statements, and in a non argumental position. We will combine an alternative semantics approach to the analysis of the FCI cualquier, inspired in Menéndez-Benito (2010) and Aloni (2019), with a syntactic approach to negation inspired in Etxepare and Uribe-Etxebarria (2011).