Characterization of the country internal variability of arsenic (As) accumulation in rice grain across different rice production regions is very important in order to analyze its compliance with international and regional limits. A robust sampling study scheme (n = 150 samples) was performed to determine total arsenic (tAs) and inorganic (iAs) levels from polished rice grain covering all rice producing regions along two growing seasons. The mean and median concentration of tAs were 0.178 mg kg-1 and 0.147 mg kg-1, with a minimum and maximum value of 0.015 mg kg−1 and 0.629 mg kg−1, respectively and a coefficient of variation of 63.6%. The mean and median concentration of iAs were 0.062 mg kg−1 and 0.055 mg kg−1 respectively ranging from 0.005 mg kg−1 up to a maximum of 0.195 mg kg−1 and a coefficient of variation of 51.5%. A moderate correlation was revealed within iAs and tAs. Levels of iAs in all of the samples were below the international limits of 0.2 mg kg−1 according to the international limits for human health by the Codex Alimentarius (FAO and WHO, 2019). Rice fields cultivated on soils originated from igneous geological material reported lower arsenic levels accumulated in rice grain in relation to sedimentary soils. Japonica cultivars presented significantly lower tAs and iAs concentrations than Indica ones (p = 0.0121 and p < 0.0001; respectively). Consumption of rice by male and female adults in Uruguay is safe according to its level of annual consumption and based on the mean iAs levels determined in this study.