A meta-analysis of the effects of colostrum heat-treatment on its viscosity and IgG concentration, and the transfer of passive immunity in newborn dairy calves.
Resumen:
ABSTRACT.- Newborn ruminants depend on colostrum intake immediately after birth to obtain immunoglobulins for effective transfer of passive immunity (TPI). As colostrum may also be a vehicle of infectious agents, heat treatment of raw colostrum is a practice aimed at eliminating or reducing its pathogen load. Despite the usefulness of heat treatment in preventing the transmission of infectious colostrum-borne diseases, heat treatment of colostrum may have some side effects. A systematic review and meta-analysis were conducted to summarize the effects of colostrum heat treatment on its viscosity and IgG concentration, and serum IgG concentration as a proxy for TPI in newborn calves fed raw versus heat-treated colostrum. Moderators were studied to identify sources of heterogeneity. Literature databases were searched for peer-reviewed articles published between 1946 and 2022. A Master of Science thesis was also included. Five, 21, and 19 original publications were quantitatively evaluated in 3 separate meta-analyses, based on predefined selection criteria. Two-level and 3-level random effects meta-analysis revealed a significant overall effect of heat treatment on colostral viscosity and IgG concentration, and serum IgG concentration in newborns. © 2023 American Dairy Science Association
| 2023 | |
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Colostrum management and transfer of passive immunity Colostrum-borne pathogens IgG denaturation Multi-level meta-analysis Neonatal infectious diseases PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA |
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| Inglés | |
| Instituto Nacional de Investigación Agropecuaria | |
| AINFO | |
| https://ainfo.inia.uy/consulta/busca?b=pc&id=64164&biblioteca=vazio&busca=64164&qFacets=64164 | |
| Acceso abierto |
| _version_ | 1856772320973029376 |
|---|---|
| author | RABAZA, A. |
| author2 | FRAGA, M. MENDOZA, A. GIANNITTI, F. |
| author2_role | author author author |
| author_facet | RABAZA, A. FRAGA, M. MENDOZA, A. GIANNITTI, F. |
| author_role | author |
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| bitstream.url.fl_str_mv | https://redi.anii.org.uy/jspui/bitstream/20.500.12381/4449/1/sword-2025-06-23T15%3a31%3a32.original.xml |
| collection | AINFO |
| dc.creator.none.fl_str_mv | RABAZA, A. FRAGA, M. MENDOZA, A. GIANNITTI, F. |
| dc.date.accessioned.none.fl_str_mv | 2025-06-23T18:31:32Z |
| dc.date.available.none.fl_str_mv | 2025-06-23T18:31:32Z |
| dc.date.issued.none.fl_str_mv | 2023 |
| dc.date.updated.none.fl_str_mv | 2025-06-23T18:31:32Z |
| dc.description.abstract.none.fl_txt_mv | ABSTRACT.- Newborn ruminants depend on colostrum intake immediately after birth to obtain immunoglobulins for effective transfer of passive immunity (TPI). As colostrum may also be a vehicle of infectious agents, heat treatment of raw colostrum is a practice aimed at eliminating or reducing its pathogen load. Despite the usefulness of heat treatment in preventing the transmission of infectious colostrum-borne diseases, heat treatment of colostrum may have some side effects. A systematic review and meta-analysis were conducted to summarize the effects of colostrum heat treatment on its viscosity and IgG concentration, and serum IgG concentration as a proxy for TPI in newborn calves fed raw versus heat-treated colostrum. Moderators were studied to identify sources of heterogeneity. Literature databases were searched for peer-reviewed articles published between 1946 and 2022. A Master of Science thesis was also included. Five, 21, and 19 original publications were quantitatively evaluated in 3 separate meta-analyses, based on predefined selection criteria. Two-level and 3-level random effects meta-analysis revealed a significant overall effect of heat treatment on colostral viscosity and IgG concentration, and serum IgG concentration in newborns. © 2023 American Dairy Science Association |
| dc.identifier.none.fl_str_mv | https://ainfo.inia.uy/consulta/busca?b=pc&id=64164&biblioteca=vazio&busca=64164&qFacets=64164 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.rights.es.fl_str_mv | Acceso abierto |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:AINFO instname:Instituto Nacional de Investigación Agropecuaria instacron:Instituto Nacional de Investigación Agropecuaria |
| dc.subject.none.fl_str_mv | Colostrum management and transfer of passive immunity Colostrum-borne pathogens IgG denaturation Multi-level meta-analysis Neonatal infectious diseases PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA |
| dc.title.none.fl_str_mv | A meta-analysis of the effects of colostrum heat-treatment on its viscosity and IgG concentration, and the transfer of passive immunity in newborn dairy calves. |
| dc.type.none.fl_str_mv | Article PublishedVersion info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | ABSTRACT.- Newborn ruminants depend on colostrum intake immediately after birth to obtain immunoglobulins for effective transfer of passive immunity (TPI). As colostrum may also be a vehicle of infectious agents, heat treatment of raw colostrum is a practice aimed at eliminating or reducing its pathogen load. Despite the usefulness of heat treatment in preventing the transmission of infectious colostrum-borne diseases, heat treatment of colostrum may have some side effects. A systematic review and meta-analysis were conducted to summarize the effects of colostrum heat treatment on its viscosity and IgG concentration, and serum IgG concentration as a proxy for TPI in newborn calves fed raw versus heat-treated colostrum. Moderators were studied to identify sources of heterogeneity. Literature databases were searched for peer-reviewed articles published between 1946 and 2022. A Master of Science thesis was also included. Five, 21, and 19 original publications were quantitatively evaluated in 3 separate meta-analyses, based on predefined selection criteria. Two-level and 3-level random effects meta-analysis revealed a significant overall effect of heat treatment on colostral viscosity and IgG concentration, and serum IgG concentration in newborns. © 2023 American Dairy Science Association |
| eu_rights_str_mv | openAccess |
| format | article |
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| publishDate | 2023 |
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| spelling | 2025-06-23T18:31:32Z2025-06-23T18:31:32Z20232025-06-23T18:31:32Zhttps://ainfo.inia.uy/consulta/busca?b=pc&id=64164&biblioteca=vazio&busca=64164&qFacets=64164ABSTRACT.- Newborn ruminants depend on colostrum intake immediately after birth to obtain immunoglobulins for effective transfer of passive immunity (TPI). As colostrum may also be a vehicle of infectious agents, heat treatment of raw colostrum is a practice aimed at eliminating or reducing its pathogen load. Despite the usefulness of heat treatment in preventing the transmission of infectious colostrum-borne diseases, heat treatment of colostrum may have some side effects. A systematic review and meta-analysis were conducted to summarize the effects of colostrum heat treatment on its viscosity and IgG concentration, and serum IgG concentration as a proxy for TPI in newborn calves fed raw versus heat-treated colostrum. Moderators were studied to identify sources of heterogeneity. Literature databases were searched for peer-reviewed articles published between 1946 and 2022. A Master of Science thesis was also included. Five, 21, and 19 original publications were quantitatively evaluated in 3 separate meta-analyses, based on predefined selection criteria. Two-level and 3-level random effects meta-analysis revealed a significant overall effect of heat treatment on colostral viscosity and IgG concentration, and serum IgG concentration in newborns. © 2023 American Dairy Science Associationhttps://hdl.handle.net/20.500.12381/4449enenginfo:eu-repo/semantics/openAccessAcceso abiertoColostrum management and transfer of passive immunityColostrum-borne pathogensIgG denaturationMulti-level meta-analysisNeonatal infectious diseasesPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIAA meta-analysis of the effects of colostrum heat-treatment on its viscosity and IgG concentration, and the transfer of passive immunity in newborn dairy calves.ArticlePublishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:AINFOinstname:Instituto Nacional de Investigación Agropecuariainstacron:Instituto Nacional de Investigación AgropecuariaRABAZA, A.FRAGA, M.MENDOZA, A.GIANNITTI, F.SWORDsword-2025-06-23T15:31:32.original.xmlOriginal SWORD entry documentapplication/octet-stream2649https://redi.anii.org.uy/jspui/bitstream/20.500.12381/4449/1/sword-2025-06-23T15%3a31%3a32.original.xml00ae93e0fcdbac303281cbe20dd44260MD5120.500.12381/44492026-02-10 15:53:57.979oai:redi.anii.org.uy:20.500.12381/4449Institucionalhttps://ainfo.inia.uy/Organismo científico-tecnológicohttp://inia.uyhttps://redi.anii.org.uy/oai/requestlorrego@inia.org.uyUruguayopendoar:2026-02-10T18:53:57AINFO - Instituto Nacional de Investigación Agropecuariafalse |
| spellingShingle | A meta-analysis of the effects of colostrum heat-treatment on its viscosity and IgG concentration, and the transfer of passive immunity in newborn dairy calves. RABAZA, A. Colostrum management and transfer of passive immunity Colostrum-borne pathogens IgG denaturation Multi-level meta-analysis Neonatal infectious diseases PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA |
| status_str | publishedVersion |
| title | A meta-analysis of the effects of colostrum heat-treatment on its viscosity and IgG concentration, and the transfer of passive immunity in newborn dairy calves. |
| title_full | A meta-analysis of the effects of colostrum heat-treatment on its viscosity and IgG concentration, and the transfer of passive immunity in newborn dairy calves. |
| title_fullStr | A meta-analysis of the effects of colostrum heat-treatment on its viscosity and IgG concentration, and the transfer of passive immunity in newborn dairy calves. |
| title_full_unstemmed | A meta-analysis of the effects of colostrum heat-treatment on its viscosity and IgG concentration, and the transfer of passive immunity in newborn dairy calves. |
| title_short | A meta-analysis of the effects of colostrum heat-treatment on its viscosity and IgG concentration, and the transfer of passive immunity in newborn dairy calves. |
| title_sort | A meta-analysis of the effects of colostrum heat-treatment on its viscosity and IgG concentration, and the transfer of passive immunity in newborn dairy calves. |
| topic | Colostrum management and transfer of passive immunity Colostrum-borne pathogens IgG denaturation Multi-level meta-analysis Neonatal infectious diseases PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA |
| url | https://ainfo.inia.uy/consulta/busca?b=pc&id=64164&biblioteca=vazio&busca=64164&qFacets=64164 |
