ABSTRACT:Megaesophagus is a rare disease in ruminants characterized by regurgitation of rumen contents. In this paperit was described cases of megaesophagus in two sheep and two goats on a farm in the state of Paraíba, Northeastern Brazil. Allanimals showed regurgitation of rumen contents and weight loss, with a clinical course of several months. At necropsy all animalspresented megaesophagus. Histological examination showed segmental muscle necrosis in the esophagus and skeletal muscles.Serum samples from one sheep and one goat were negative for the presence of blue tongue antibodies by ELISA, and whole bloodand muscle samples from one goat were negative for this virus by RT PCR. Epidemiological data and pathology suggested that thedisease could have been caused by some toxic plant, but known plants causing segmental muscle necrosis were not observed in theareas where the disease occurred.