Neuroprotection by the cannabis-related products, cannabidiol and cannabigerol, and their associated mechanisms of action
Resumen:
The discovery and characterization of the endocannabinoid system (ECS) brought out years of research focusing on two aims. The study of its participation in the physiopathology in several diseases, including neurodegenerative disorders, and as a direct or indirect target for treating these disorders by cannabinoids or phytocannabinoids (i.e., specific compounds present in the Cannabis sativa plant). Preclinical evidence and some clinical data have shown the therapeutic potential of the most relevant phytocannabinoids, Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), but less for cannabigerol (CBG). In the present review, we summarized data focused on the therapeutic potential of CBD and CBG as neuroprotective agents. This property appears to be exerted by the direct or indirect activation of targets within the ECS and also by mechanisms non-mediated by the ECS. We provide information which could be useful for future CBD and CBG applications in human neurodegenerative diseases treatment.
| 2023 | |
| Agencia Nacional de Investigación e Innovación | |
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Neurodegenerative diseases Endocannabinoid system Phytocannabinoids Cell survival Neuroprotective agents Ciencias Médicas y de la Salud Medicina Básica Neurociencias |
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| Inglés | |
| Instituto de Investigaciones Biológicas Clemente Estable | |
| IIBCE en REDI | |
|
https://hdl.handle.net/20.500.12381/3315
https://doi.org/10.1016/B978-0-323-90036-2.00039-9 |
|
| Acceso abierto | |
| Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional. (CC BY-NC-SA) |
| _version_ | 1811155751194853376 |
|---|---|
| author | Echeverry, Carolina |
| author2 | Fagetti, Jimena Reyes-Parada, Miguel Scorza, Cecilia |
| author2_role | author author author |
| author_facet | Echeverry, Carolina Fagetti, Jimena Reyes-Parada, Miguel Scorza, Cecilia |
| author_role | author |
| bitstream.checksum.fl_str_mv | fcc8b2ddb26c820405a37f9e0cae7f18 ea614f0e39c3eb7a5d432c57ab54a025 |
| bitstream.checksumAlgorithm.fl_str_mv | MD5 MD5 |
| bitstream.url.fl_str_mv | https://redi.anii.org.uy/jspui/bitstream/20.500.12381/3315/4/license.txt https://redi.anii.org.uy/jspui/bitstream/20.500.12381/3315/3/Chapter%20Echeverry%20et%20al.%202023.pdf |
| collection | IIBCE en REDI |
| dc.creator.none.fl_str_mv | Echeverry, Carolina Fagetti, Jimena Reyes-Parada, Miguel Scorza, Cecilia |
| dc.date.accessioned.none.fl_str_mv | 2023-11-01T16:00:07Z |
| dc.date.available.none.fl_str_mv | 2023-11-01T16:00:07Z |
| dc.date.issued.none.fl_str_mv | 2023-06-19 |
| dc.description.abstract.none.fl_txt_mv | The discovery and characterization of the endocannabinoid system (ECS) brought out years of research focusing on two aims. The study of its participation in the physiopathology in several diseases, including neurodegenerative disorders, and as a direct or indirect target for treating these disorders by cannabinoids or phytocannabinoids (i.e., specific compounds present in the Cannabis sativa plant). Preclinical evidence and some clinical data have shown the therapeutic potential of the most relevant phytocannabinoids, Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), but less for cannabigerol (CBG). In the present review, we summarized data focused on the therapeutic potential of CBD and CBG as neuroprotective agents. This property appears to be exerted by the direct or indirect activation of targets within the ECS and also by mechanisms non-mediated by the ECS. We provide information which could be useful for future CBD and CBG applications in human neurodegenerative diseases treatment. |
| dc.description.sponsorship.none.fl_txt_mv | Agencia Nacional de Investigación e Innovación |
| dc.identifier.anii.es.fl_str_mv | FCE_3_2020_1_162440 |
| dc.identifier.doi.none.fl_str_mv | https://doi.org/10.1016/B978-0-323-90036-2.00039-9 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12381/3315 |
| dc.language.iso.none.fl_str_mv | eng |
| dc.publisher.es.fl_str_mv | Academic Press Elsevier |
| dc.rights.*.fl_str_mv | Acceso abierto |
| dc.rights.license.none.fl_str_mv | Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional. (CC BY-NC-SA) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.es.fl_str_mv | Medicinal Usage of Cannabis and Cannabinoids |
| dc.source.none.fl_str_mv | reponame:IIBCE en REDI instname:Instituto de Investigaciones Biológicas Clemente Estable instacron:Instituto de Investigaciones Biológicas Clemente Estable |
| dc.subject.anii.none.fl_str_mv | Ciencias Médicas y de la Salud Medicina Básica Neurociencias |
| dc.subject.es.fl_str_mv | Neurodegenerative diseases Endocannabinoid system Phytocannabinoids Cell survival Neuroprotective agents |
| dc.title.none.fl_str_mv | Neuroprotection by the cannabis-related products, cannabidiol and cannabigerol, and their associated mechanisms of action |
| dc.type.es.fl_str_mv | Parte de libro |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/bookPart |
| dc.type.version.es.fl_str_mv | Aceptado |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/acceptedVersion |
| description | The discovery and characterization of the endocannabinoid system (ECS) brought out years of research focusing on two aims. The study of its participation in the physiopathology in several diseases, including neurodegenerative disorders, and as a direct or indirect target for treating these disorders by cannabinoids or phytocannabinoids (i.e., specific compounds present in the Cannabis sativa plant). Preclinical evidence and some clinical data have shown the therapeutic potential of the most relevant phytocannabinoids, Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), but less for cannabigerol (CBG). In the present review, we summarized data focused on the therapeutic potential of CBD and CBG as neuroprotective agents. This property appears to be exerted by the direct or indirect activation of targets within the ECS and also by mechanisms non-mediated by the ECS. We provide information which could be useful for future CBD and CBG applications in human neurodegenerative diseases treatment. |
| eu_rights_str_mv | openAccess |
| format | bookPart |
| id | IIBCE_1b1c058462c4aae903f6859bca387b26 |
| identifier_str_mv | FCE_3_2020_1_162440 |
| instacron_str | Instituto de Investigaciones Biológicas Clemente Estable |
| institution | Instituto de Investigaciones Biológicas Clemente Estable |
| instname_str | Instituto de Investigaciones Biológicas Clemente Estable |
| language | eng |
| network_acronym_str | IIBCE |
| network_name_str | IIBCE en REDI |
| oai_identifier_str | oai:redi.anii.org.uy:20.500.12381/3315 |
| publishDate | 2023 |
| reponame_str | IIBCE en REDI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | IIBCE en REDI - Instituto de Investigaciones Biológicas Clemente Estable |
| repository_id_str | 9421_3 |
| rights_invalid_str_mv | Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional. (CC BY-NC-SA) Acceso abierto |
| spelling | Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional. (CC BY-NC-SA)Acceso abiertoinfo:eu-repo/semantics/openAccess2023-11-01T16:00:07Z2023-11-01T16:00:07Z2023-06-19https://hdl.handle.net/20.500.12381/3315FCE_3_2020_1_162440https://doi.org/10.1016/B978-0-323-90036-2.00039-9The discovery and characterization of the endocannabinoid system (ECS) brought out years of research focusing on two aims. The study of its participation in the physiopathology in several diseases, including neurodegenerative disorders, and as a direct or indirect target for treating these disorders by cannabinoids or phytocannabinoids (i.e., specific compounds present in the Cannabis sativa plant). Preclinical evidence and some clinical data have shown the therapeutic potential of the most relevant phytocannabinoids, Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), but less for cannabigerol (CBG). In the present review, we summarized data focused on the therapeutic potential of CBD and CBG as neuroprotective agents. This property appears to be exerted by the direct or indirect activation of targets within the ECS and also by mechanisms non-mediated by the ECS. We provide information which could be useful for future CBD and CBG applications in human neurodegenerative diseases treatment.Agencia Nacional de Investigación e InnovaciónengAcademic PressElsevierMedicinal Usage of Cannabis and Cannabinoidsreponame:IIBCE en REDIinstname:Instituto de Investigaciones Biológicas Clemente Estableinstacron:Instituto de Investigaciones Biológicas Clemente EstableNeurodegenerative diseasesEndocannabinoid systemPhytocannabinoidsCell survivalNeuroprotective agentsCiencias Médicas y de la SaludMedicina BásicaNeurocienciasNeuroprotection by the cannabis-related products, cannabidiol and cannabigerol, and their associated mechanisms of actionParte de libroAceptadoinfo:eu-repo/semantics/acceptedVersioninfo:eu-repo/semantics/bookPartInstituto de Investigaciones Biológicas Clemente Estable//Ciencias Médicas y de la Salud/Medicina Básica/NeurocienciasEcheverry, CarolinaFagetti, JimenaReyes-Parada, MiguelScorza, CeciliaLICENSElicense.txtlicense.txttext/plain; charset=utf-85151https://redi.anii.org.uy/jspui/bitstream/20.500.12381/3315/4/license.txtfcc8b2ddb26c820405a37f9e0cae7f18MD54ORIGINALChapter Echeverry et al. 2023.pdfChapter Echeverry et al. 2023.pdfCapitulo de libro Medicinal Usage of Cannabis and Cannabinoidsapplication/pdf254483https://redi.anii.org.uy/jspui/bitstream/20.500.12381/3315/3/Chapter%20Echeverry%20et%20al.%202023.pdfea614f0e39c3eb7a5d432c57ab54a025MD5320.500.12381/33152023-11-01 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| spellingShingle | Neuroprotection by the cannabis-related products, cannabidiol and cannabigerol, and their associated mechanisms of action Echeverry, Carolina Neurodegenerative diseases Endocannabinoid system Phytocannabinoids Cell survival Neuroprotective agents Ciencias Médicas y de la Salud Medicina Básica Neurociencias |
| status_str | acceptedVersion |
| title | Neuroprotection by the cannabis-related products, cannabidiol and cannabigerol, and their associated mechanisms of action |
| title_full | Neuroprotection by the cannabis-related products, cannabidiol and cannabigerol, and their associated mechanisms of action |
| title_fullStr | Neuroprotection by the cannabis-related products, cannabidiol and cannabigerol, and their associated mechanisms of action |
| title_full_unstemmed | Neuroprotection by the cannabis-related products, cannabidiol and cannabigerol, and their associated mechanisms of action |
| title_short | Neuroprotection by the cannabis-related products, cannabidiol and cannabigerol, and their associated mechanisms of action |
| title_sort | Neuroprotection by the cannabis-related products, cannabidiol and cannabigerol, and their associated mechanisms of action |
| topic | Neurodegenerative diseases Endocannabinoid system Phytocannabinoids Cell survival Neuroprotective agents Ciencias Médicas y de la Salud Medicina Básica Neurociencias |
| url | https://hdl.handle.net/20.500.12381/3315 https://doi.org/10.1016/B978-0-323-90036-2.00039-9 |
