Functional ultrasound in the brain of TrJ mice, a model of the neurodegenerative disease of Charcot Marie Tooth
Resumen:
Charcot-Marie-Tooth’s (CMT) disease is the most commonly human inherited neurological disorder, and is described as a peripheral nervous alteration. Trembler-J (TrJ) mice model this condition with the same spontaneous mutation as in human variant CMT1E . Recent studies in TrJ evidenced alterations in the central nervous system (Damián et al 2021, Biomolecules). To further verify this hypothesis, in this work we used functional ultrasound (fUS) to examine the vascular brain's response to an external stimulus. To our understanding, this is the first neurological functional analysis that studies this disease.
| 2023 | |
| ANII: FCE_1_2019_1_155539 | |
|
Functional ultrasound Neurovascular degeneration Charcot-Marie-Tooth disease |
|
| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/38347 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| _version_ | 1807522796760203264 |
|---|---|
| author | Anzibar Fialho, Maximiliano |
| author2 | Rubido, Nicolás Martínez, Mariana Vázquez Alberdi, Lucía Negreira, Carlos Tanter, Mickael |
| author2_role | author author author author author |
| author_facet | Anzibar Fialho, Maximiliano Rubido, Nicolás Martínez, Mariana Vázquez Alberdi, Lucía Negreira, Carlos Tanter, Mickael |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Anzibar Fialho Maximiliano, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física. Rubido Nicolás, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física. Martínez Mariana, IIBCE Vázquez Alberdi Lucía, IIBCE Negreira Carlos, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física. Tanter Mickael |
| dc.creator.none.fl_str_mv | Anzibar Fialho, Maximiliano Rubido, Nicolás Martínez, Mariana Vázquez Alberdi, Lucía Negreira, Carlos Tanter, Mickael |
| dc.date.accessioned.none.fl_str_mv | 2023-07-24T13:18:06Z |
| dc.date.available.none.fl_str_mv | 2023-07-24T13:18:06Z |
| dc.date.issued.none.fl_str_mv | 2023 |
| dc.description.abstract.none.fl_txt_mv | Charcot-Marie-Tooth’s (CMT) disease is the most commonly human inherited neurological disorder, and is described as a peripheral nervous alteration. Trembler-J (TrJ) mice model this condition with the same spontaneous mutation as in human variant CMT1E . Recent studies in TrJ evidenced alterations in the central nervous system (Damián et al 2021, Biomolecules). To further verify this hypothesis, in this work we used functional ultrasound (fUS) to examine the vascular brain's response to an external stimulus. To our understanding, this is the first neurological functional analysis that studies this disease. |
| dc.description.sponsorship.none.fl_txt_mv | ANII: FCE_1_2019_1_155539 |
| dc.format.extent.es.fl_str_mv | 1 h |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Anzibar Fialho, M, Rubido, N, Martínez, M, [y otros autores]. Functional ultrasound in the brain of TrJ mice, a model of the neurodegenerative disease of Charcot Marie Tooth. [en línea] EN: IEEE International Ultrasonics Symposium 3-7 September, 2023, Montreal. 1 h. |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/38347 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | IEEE |
| dc.relation.ispartof.es.fl_str_mv | IEEE International Ultrasonics Symposium 3-7 September , 2023, Montreal |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | Functional ultrasound Neurovascular degeneration Charcot-Marie-Tooth disease |
| dc.title.none.fl_str_mv | Functional ultrasound in the brain of TrJ mice, a model of the neurodegenerative disease of Charcot Marie Tooth |
| dc.type.es.fl_str_mv | Ponencia |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/conferenceObject |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Charcot-Marie-Tooth’s (CMT) disease is the most commonly human inherited neurological disorder, and is described as a peripheral nervous alteration. Trembler-J (TrJ) mice model this condition with the same spontaneous mutation as in human variant CMT1E . Recent studies in TrJ evidenced alterations in the central nervous system (Damián et al 2021, Biomolecules). To further verify this hypothesis, in this work we used functional ultrasound (fUS) to examine the vascular brain's response to an external stimulus. To our understanding, this is the first neurological functional analysis that studies this disease. |
| eu_rights_str_mv | openAccess |
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| id | COLIBRI_fe388512167f48c283640ec5159dfe43 |
| identifier_str_mv | Anzibar Fialho, M, Rubido, N, Martínez, M, [y otros autores]. Functional ultrasound in the brain of TrJ mice, a model of the neurodegenerative disease of Charcot Marie Tooth. [en línea] EN: IEEE International Ultrasonics Symposium 3-7 September, 2023, Montreal. 1 h. |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/38347 |
| publishDate | 2023 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | mabel.seroubian@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| spelling | Anzibar Fialho Maximiliano, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física.Rubido Nicolás, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física.Martínez Mariana, IIBCEVázquez Alberdi Lucía, IIBCENegreira Carlos, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física.Tanter Mickael2023-07-24T13:18:06Z2023-07-24T13:18:06Z2023Anzibar Fialho, M, Rubido, N, Martínez, M, [y otros autores]. Functional ultrasound in the brain of TrJ mice, a model of the neurodegenerative disease of Charcot Marie Tooth. [en línea] EN: IEEE International Ultrasonics Symposium 3-7 September, 2023, Montreal. 1 h.https://hdl.handle.net/20.500.12008/38347Charcot-Marie-Tooth’s (CMT) disease is the most commonly human inherited neurological disorder, and is described as a peripheral nervous alteration. Trembler-J (TrJ) mice model this condition with the same spontaneous mutation as in human variant CMT1E . Recent studies in TrJ evidenced alterations in the central nervous system (Damián et al 2021, Biomolecules). To further verify this hypothesis, in this work we used functional ultrasound (fUS) to examine the vascular brain's response to an external stimulus. To our understanding, this is the first neurological functional analysis that studies this disease.Submitted by Faget Cecilia (lfaget@fcien.edu.uy) on 2023-07-24T13:00:26Z No. of bitstreams: 2 license_rdf: 23149 bytes, checksum: 1996b8461bc290aef6a27d78c67b6b52 (MD5) IEEE Abstract_FINAL 2023.pdf: 209828 bytes, checksum: c219580017c578ef26c34f6daaaee74c (MD5)Approved for entry into archive by Faget Cecilia (lfaget@fcien.edu.uy) on 2023-07-24T13:00:36Z (GMT) No. of bitstreams: 2 license_rdf: 23149 bytes, checksum: 1996b8461bc290aef6a27d78c67b6b52 (MD5) IEEE Abstract_FINAL 2023.pdf: 209828 bytes, checksum: c219580017c578ef26c34f6daaaee74c (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2023-07-24T13:18:06Z (GMT). No. of bitstreams: 2 license_rdf: 23149 bytes, checksum: 1996b8461bc290aef6a27d78c67b6b52 (MD5) IEEE Abstract_FINAL 2023.pdf: 209828 bytes, checksum: c219580017c578ef26c34f6daaaee74c (MD5) Previous issue date: 2023ANII: FCE_1_2019_1_1555391 happlication/pdfenengIEEEIEEE International Ultrasonics Symposium 3-7 September , 2023, MontrealLas obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)Functional ultrasoundNeurovascular degenerationCharcot-Marie-Tooth diseaseFunctional ultrasound in the brain of TrJ mice, a model of the neurodegenerative disease of Charcot Marie ToothPonenciainfo:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaAnzibar Fialho, MaximilianoRubido, NicolásMartínez, MarianaVázquez Alberdi, LucíaNegreira, CarlosTanter, MickaelLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/38347/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-850http://localhost:8080/xmlui/bitstream/20.500.12008/38347/2/license_urla006180e3f5b2ad0b88185d14284c0e0MD52license_textlicense_texttext/html; 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- Universidad de la Repúblicafalse |
| spellingShingle | Functional ultrasound in the brain of TrJ mice, a model of the neurodegenerative disease of Charcot Marie Tooth Anzibar Fialho, Maximiliano Functional ultrasound Neurovascular degeneration Charcot-Marie-Tooth disease |
| status_str | publishedVersion |
| title | Functional ultrasound in the brain of TrJ mice, a model of the neurodegenerative disease of Charcot Marie Tooth |
| title_full | Functional ultrasound in the brain of TrJ mice, a model of the neurodegenerative disease of Charcot Marie Tooth |
| title_fullStr | Functional ultrasound in the brain of TrJ mice, a model of the neurodegenerative disease of Charcot Marie Tooth |
| title_full_unstemmed | Functional ultrasound in the brain of TrJ mice, a model of the neurodegenerative disease of Charcot Marie Tooth |
| title_short | Functional ultrasound in the brain of TrJ mice, a model of the neurodegenerative disease of Charcot Marie Tooth |
| title_sort | Functional ultrasound in the brain of TrJ mice, a model of the neurodegenerative disease of Charcot Marie Tooth |
| topic | Functional ultrasound Neurovascular degeneration Charcot-Marie-Tooth disease |
| url | https://hdl.handle.net/20.500.12008/38347 |
