Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding
Resumen:
This study aimed to present two cases of ghost cell odontogenic lesions (GCOL) with granular cells, an unusual finding, in order to contribute to their immunohistochemical characterization and compare results with previous reports. One case corresponded to a calcifying odontogenic cyst (COC) in a 44-year-old man and the other to a dentinogenic ghost cell tumor (DGCT) presenting in an 84-year-old woman. Both lesions were located in the mandible. Microscopically, COC showed a cystic wall lined by ameloblastic/ameloblastomatous epithelium with ghost cells, and DGCT showed ameloblastomatous proliferation with ghost cells and dentinoid/osteodentin matrix. In addition, the presence of cells with abundant granular cytoplasm was observed within the epithelial lining in the cystic lesion and trapped in the dentinoid matrix in the neoplastic lesion. In both cases, the granular cells were positive for AE1-AE3, S100, and CD68; additionally, granular cells in the DGCT were positive for CK19, amelogenin, β-catenin, E-cadherin, vimentin, and lysozyme. The immunohistochemical profile suggests an epithelial origin of granular cells with an increase in lysosomes possibly associated with a degenerative process. Further studies are necessary to clarify the origin of these cells.
| 2025 | |
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Ghost cell Odontogenic lesions Calcifying odontogenic cyst Dentinogenic ghost cell tumor Granular cells Immunohistochemistry QUISTE ODONTOGÉNICO CALCIFICADO INMUNOHISTOQUÍMICA |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/51676 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| _version_ | 1877555177893920768 |
|---|---|
| author | Polti, Lucas Fabian |
| author2 | Sicco, Estefanía Silveira, Felipe Martins Schuch, Lauren Frenzel Pereira-Prado, Vanesa Bologna-Molina, Ronell Paparella, María Luisa |
| author2_role | author author author author author author |
| author_facet | Polti, Lucas Fabian Sicco, Estefanía Silveira, Felipe Martins Schuch, Lauren Frenzel Pereira-Prado, Vanesa Bologna-Molina, Ronell Paparella, María Luisa |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Polti Lucas Fabian, Universidad de Buenos Aires (Uruguay). Facultad de Odontología. Sicco Estefanía, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral. Silveira Felipe Martins, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral. Schuch Lauren Frenzel, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral. Pereira-Prado Vanesa, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral. Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral. Paparella María Luisa, Universidad de Buenos Aires (Uruguay). Facultad de Odontología. |
| dc.creator.none.fl_str_mv | Polti, Lucas Fabian Sicco, Estefanía Silveira, Felipe Martins Schuch, Lauren Frenzel Pereira-Prado, Vanesa Bologna-Molina, Ronell Paparella, María Luisa |
| dc.date.accessioned.none.fl_str_mv | 2025-09-17T17:22:19Z |
| dc.date.available.none.fl_str_mv | 2025-09-17T17:22:19Z |
| dc.date.issued.none.fl_str_mv | 2025 |
| dc.description.abstract.none.fl_txt_mv | This study aimed to present two cases of ghost cell odontogenic lesions (GCOL) with granular cells, an unusual finding, in order to contribute to their immunohistochemical characterization and compare results with previous reports. One case corresponded to a calcifying odontogenic cyst (COC) in a 44-year-old man and the other to a dentinogenic ghost cell tumor (DGCT) presenting in an 84-year-old woman. Both lesions were located in the mandible. Microscopically, COC showed a cystic wall lined by ameloblastic/ameloblastomatous epithelium with ghost cells, and DGCT showed ameloblastomatous proliferation with ghost cells and dentinoid/osteodentin matrix. In addition, the presence of cells with abundant granular cytoplasm was observed within the epithelial lining in the cystic lesion and trapped in the dentinoid matrix in the neoplastic lesion. In both cases, the granular cells were positive for AE1-AE3, S100, and CD68; additionally, granular cells in the DGCT were positive for CK19, amelogenin, β-catenin, E-cadherin, vimentin, and lysozyme. The immunohistochemical profile suggests an epithelial origin of granular cells with an increase in lysosomes possibly associated with a degenerative process. Further studies are necessary to clarify the origin of these cells. |
| dc.format.extent.es.fl_str_mv | 9 h. |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Polti, L, Sicco, E, Silveira, F [y otros autores]. "Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding". Journal of Oral Diagnosis. [en línea] 2025, 10:e354. 9 h. |
| dc.identifier.doi.none.fl_str_mv | 10.5327/2525-5711.34 |
| dc.identifier.issn.none.fl_str_mv | 2525-5711 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/51676 |
| dc.language.iso.none.fl_str_mv | en_US eng |
| dc.publisher.es.fl_str_mv | Brazilian Society of Oral Medicine and Oral Pathology (SOBEP). |
| dc.relation.none.fl_str_mv | Journal of Oral Diagnosis, 2025, 10:e354. |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | Ghost cell Odontogenic lesions Calcifying odontogenic cyst Dentinogenic ghost cell tumor Granular cells Immunohistochemistry |
| dc.subject.other.es.fl_str_mv | QUISTE ODONTOGÉNICO CALCIFICADO INMUNOHISTOQUÍMICA |
| dc.title.none.fl_str_mv | Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | This study aimed to present two cases of ghost cell odontogenic lesions (GCOL) with granular cells, an unusual finding, in order to contribute to their immunohistochemical characterization and compare results with previous reports. One case corresponded to a calcifying odontogenic cyst (COC) in a 44-year-old man and the other to a dentinogenic ghost cell tumor (DGCT) presenting in an 84-year-old woman. Both lesions were located in the mandible. Microscopically, COC showed a cystic wall lined by ameloblastic/ameloblastomatous epithelium with ghost cells, and DGCT showed ameloblastomatous proliferation with ghost cells and dentinoid/osteodentin matrix. In addition, the presence of cells with abundant granular cytoplasm was observed within the epithelial lining in the cystic lesion and trapped in the dentinoid matrix in the neoplastic lesion. In both cases, the granular cells were positive for AE1-AE3, S100, and CD68; additionally, granular cells in the DGCT were positive for CK19, amelogenin, β-catenin, E-cadherin, vimentin, and lysozyme. The immunohistochemical profile suggests an epithelial origin of granular cells with an increase in lysosomes possibly associated with a degenerative process. Further studies are necessary to clarify the origin of these cells. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_ee20f237d5fedcb3d0ff5f8a45b63edc |
| identifier_str_mv | Polti, L, Sicco, E, Silveira, F [y otros autores]. "Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding". Journal of Oral Diagnosis. [en línea] 2025, 10:e354. 9 h. 2525-5711 10.5327/2525-5711.34 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en_US |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/51676 |
| publishDate | 2025 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | karina.camps@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Polti Lucas Fabian, Universidad de Buenos Aires (Uruguay). Facultad de Odontología.Sicco Estefanía, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Silveira Felipe Martins, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Schuch Lauren Frenzel, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Pereira-Prado Vanesa, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Paparella María Luisa, Universidad de Buenos Aires (Uruguay). Facultad de Odontología.2025-09-17T17:22:19Z2025-09-17T17:22:19Z2025Polti, L, Sicco, E, Silveira, F [y otros autores]. "Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding". Journal of Oral Diagnosis. [en línea] 2025, 10:e354. 9 h.2525-5711https://hdl.handle.net/20.500.12008/5167610.5327/2525-5711.34This study aimed to present two cases of ghost cell odontogenic lesions (GCOL) with granular cells, an unusual finding, in order to contribute to their immunohistochemical characterization and compare results with previous reports. One case corresponded to a calcifying odontogenic cyst (COC) in a 44-year-old man and the other to a dentinogenic ghost cell tumor (DGCT) presenting in an 84-year-old woman. Both lesions were located in the mandible. Microscopically, COC showed a cystic wall lined by ameloblastic/ameloblastomatous epithelium with ghost cells, and DGCT showed ameloblastomatous proliferation with ghost cells and dentinoid/osteodentin matrix. In addition, the presence of cells with abundant granular cytoplasm was observed within the epithelial lining in the cystic lesion and trapped in the dentinoid matrix in the neoplastic lesion. In both cases, the granular cells were positive for AE1-AE3, S100, and CD68; additionally, granular cells in the DGCT were positive for CK19, amelogenin, β-catenin, E-cadherin, vimentin, and lysozyme. The immunohistochemical profile suggests an epithelial origin of granular cells with an increase in lysosomes possibly associated with a degenerative process. Further studies are necessary to clarify the origin of these cells.Submitted by Farias Verónica (verofariasblundell@gmail.com) on 2025-09-16T20:06:46Z No. of bitstreams: 2 license_rdf: 24942 bytes, checksum: 58cb336ce230a47d2f88ad02838a665f (MD5) 10532725255711354.pdf: 13668067 bytes, checksum: 3bae89fbc5f104a278f3c000b6e6d4b1 (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2025-09-17T17:22:19Z (GMT). No. of bitstreams: 2 license_rdf: 24942 bytes, checksum: 58cb336ce230a47d2f88ad02838a665f (MD5) 10532725255711354.pdf: 13668067 bytes, checksum: 3bae89fbc5f104a278f3c000b6e6d4b1 (MD5) Previous issue date: 20259 h.application/pdfen_USengBrazilian Society of Oral Medicine and Oral Pathology (SOBEP).Journal of Oral Diagnosis, 2025, 10:e354.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)Ghost cellOdontogenic lesionsCalcifying odontogenic cystDentinogenic ghost cell tumorGranular cellsImmunohistochemistryQUISTE ODONTOGÉNICO CALCIFICADOINMUNOHISTOQUÍMICAGranular cells in ghost cell odontogenic lesions: an unusual and unexpected findingArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaPolti, Lucas FabianSicco, EstefaníaSilveira, Felipe MartinsSchuch, Lauren FrenzelPereira-Prado, VanesaBologna-Molina, RonellPaparella, María LuisaLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/51676/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; 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- Universidad de la Repúblicafalse |
| spellingShingle | Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding Polti, Lucas Fabian Ghost cell Odontogenic lesions Calcifying odontogenic cyst Dentinogenic ghost cell tumor Granular cells Immunohistochemistry QUISTE ODONTOGÉNICO CALCIFICADO INMUNOHISTOQUÍMICA |
| status_str | publishedVersion |
| title | Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding |
| title_full | Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding |
| title_fullStr | Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding |
| title_full_unstemmed | Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding |
| title_short | Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding |
| title_sort | Granular cells in ghost cell odontogenic lesions: an unusual and unexpected finding |
| topic | Ghost cell Odontogenic lesions Calcifying odontogenic cyst Dentinogenic ghost cell tumor Granular cells Immunohistochemistry QUISTE ODONTOGÉNICO CALCIFICADO INMUNOHISTOQUÍMICA |
| url | https://hdl.handle.net/20.500.12008/51676 |
