This article presents a case study related to environmental noise exposure of cyclists in Montevideo (Uruguay), as a part of a wider interdisciplinary research project. The main objective of this study was to find the most important parameters related to cyclists’ noise exposure in the city. Two monitoring routes were defined, and their traffic flows were characterized. After that, noise dosimetries were carried out along the monitoring routes, determining a set of relevant parameters for each measurement: LAeq, LAF,10, LAF,90, noise climate (LAF,10–LAF,90), kurtosis, occupational and environmental noise doses, exceedance time for each dose, and traffic flow by categories met during cycling. A total of 66 noise dosimetries were carried out: 34 on Route N°1 and 32 on Route N°2. LAeq was lower in Route N°1. With a basis in multivariate tests, the main variables related to noise exposure of cyclists were found to be the following: kurtosis; noise climate; total traffic; and number of trucks met during the trip. Noise doses were lower on Route N°1, as well as exceedance times, presenting this route with lower traffic flow and fewer trucks but narrower streets and higher street aspect ratio values. Better knowledge in terms of selecting healthier places for cycling routes was obtained: traffic flow—and not urban geometric characteristics—was found to be the main urban determinant of high noise doses.