Compartment and cell-type specific hypoxia responses in the developing Drosophila brain
Resumen:
Environmental factors such as the availability of oxygen are instructive cues that regulate stem cell maintenance and differentiation. We used a genetically encoded biosensor to monitor the hypoxic state of neural cells in the larval brain of Drosophila. The biosensor reveals brain compartment and cell-type specific levels of hypoxia. The values correlate with differential tracheolation that is observed throughout development between the central brain and the optic lobe. Neural stem cells in both compartments show the strongest hypoxia response while intermediate progenitors, neurons and glial cells reveal weaker responses. We demonstrate that the distance between a cell and the next closest tracheole is a good predictor of the hypoxic state of that cell. Our study indicates that oxygen availability appears to be the major factor controlling the hypoxia response in the developing Drosophila brain and that cell intrinsic and cell-type specific factors contribute to modulate the response in an unexpected manner.
| 2020 | |
| ANII: FCE_3_2013_1_100732 | |
|
Drosophila Brain development Hypoxia Neural stem cell Tracheolation |
|
| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/31353 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| _version_ | 1807522788714479616 |
|---|---|
| author | Baccino, Martín |
| author2 | Prieto Mena, Daniel Cantera, Rafael Egger, Boris |
| author2_role | author author author |
| author_facet | Baccino, Martín Prieto Mena, Daniel Cantera, Rafael Egger, Boris |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Baccino Martín, IIBCE Prieto Mena Daniel, IIBCE Cantera Rafael, IIBCE Egger Boris, Universidad de Friburgo (Suiza) |
| dc.creator.none.fl_str_mv | Baccino, Martín Prieto Mena, Daniel Cantera, Rafael Egger, Boris |
| dc.date.accessioned.none.fl_str_mv | 2022-04-28T13:49:09Z |
| dc.date.available.none.fl_str_mv | 2022-04-28T13:49:09Z |
| dc.date.issued.none.fl_str_mv | 2020 |
| dc.description.abstract.none.fl_txt_mv | Environmental factors such as the availability of oxygen are instructive cues that regulate stem cell maintenance and differentiation. We used a genetically encoded biosensor to monitor the hypoxic state of neural cells in the larval brain of Drosophila. The biosensor reveals brain compartment and cell-type specific levels of hypoxia. The values correlate with differential tracheolation that is observed throughout development between the central brain and the optic lobe. Neural stem cells in both compartments show the strongest hypoxia response while intermediate progenitors, neurons and glial cells reveal weaker responses. We demonstrate that the distance between a cell and the next closest tracheole is a good predictor of the hypoxic state of that cell. Our study indicates that oxygen availability appears to be the major factor controlling the hypoxia response in the developing Drosophila brain and that cell intrinsic and cell-type specific factors contribute to modulate the response in an unexpected manner. |
| dc.description.es.fl_txt_mv | Material suplementario: https://bio.biologists.org/lookup/doi/10.1242/bio.053629.supplemental |
| dc.description.sponsorship.none.fl_txt_mv | ANII: FCE_3_2013_1_100732 |
| dc.format.extent.es.fl_str_mv | 12 h |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Baccino, M, Prieto Mena, D, Cantera, R y otros "Compartment and cell-type specific hypoxia responses in the developing Drosophila brain". Biology Open. [en línea] 2020, 9: bio053629. doi: 10.1242/bio.053629 |
| dc.identifier.doi.none.fl_str_mv | 10.1242/bio.053629 |
| dc.identifier.issn.none.fl_str_mv | 2046-6390 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/31353 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | The Company of Biologists |
| dc.relation.ispartof.es.fl_str_mv | Biology Open, 2020, 9: bio053629 |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | Drosophila Brain development Hypoxia Neural stem cell Tracheolation |
| dc.title.none.fl_str_mv | Compartment and cell-type specific hypoxia responses in the developing Drosophila brain |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Material suplementario: https://bio.biologists.org/lookup/doi/10.1242/bio.053629.supplemental |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_e9a3160cc67f66a4d2803b6ba02ef68f |
| identifier_str_mv | Baccino, M, Prieto Mena, D, Cantera, R y otros "Compartment and cell-type specific hypoxia responses in the developing Drosophila brain". Biology Open. [en línea] 2020, 9: bio053629. doi: 10.1242/bio.053629 2046-6390 10.1242/bio.053629 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/31353 |
| publishDate | 2020 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | mabel.seroubian@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Baccino Martín, IIBCEPrieto Mena Daniel, IIBCECantera Rafael, IIBCEEgger Boris, Universidad de Friburgo (Suiza)2022-04-28T13:49:09Z2022-04-28T13:49:09Z2020Baccino, M, Prieto Mena, D, Cantera, R y otros "Compartment and cell-type specific hypoxia responses in the developing Drosophila brain". Biology Open. [en línea] 2020, 9: bio053629. doi: 10.1242/bio.0536292046-6390https://hdl.handle.net/20.500.12008/3135310.1242/bio.053629Material suplementario: https://bio.biologists.org/lookup/doi/10.1242/bio.053629.supplementalEnvironmental factors such as the availability of oxygen are instructive cues that regulate stem cell maintenance and differentiation. We used a genetically encoded biosensor to monitor the hypoxic state of neural cells in the larval brain of Drosophila. The biosensor reveals brain compartment and cell-type specific levels of hypoxia. The values correlate with differential tracheolation that is observed throughout development between the central brain and the optic lobe. Neural stem cells in both compartments show the strongest hypoxia response while intermediate progenitors, neurons and glial cells reveal weaker responses. We demonstrate that the distance between a cell and the next closest tracheole is a good predictor of the hypoxic state of that cell. Our study indicates that oxygen availability appears to be the major factor controlling the hypoxia response in the developing Drosophila brain and that cell intrinsic and cell-type specific factors contribute to modulate the response in an unexpected manner.Submitted by Faget Cecilia (lfaget@fcien.edu.uy) on 2022-04-26T12:56:53Z No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) bio053629.pdf: 7177282 bytes, checksum: 083ed86ad1516709fe73d59f9610e12d (MD5)Approved for entry into archive by Faget Cecilia (lfaget@fcien.edu.uy) on 2022-04-27T17:58:40Z (GMT) No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) bio053629.pdf: 7177282 bytes, checksum: 083ed86ad1516709fe73d59f9610e12d (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2022-04-28T13:49:09Z (GMT). No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) bio053629.pdf: 7177282 bytes, checksum: 083ed86ad1516709fe73d59f9610e12d (MD5) Previous issue date: 2020ANII: FCE_3_2013_1_10073212 happlication/pdfenengThe Company of BiologistsBiology Open, 2020, 9: bio053629Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)DrosophilaBrain developmentHypoxiaNeural stem cellTracheolationCompartment and cell-type specific hypoxia responses in the developing Drosophila brainArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaBaccino, MartínPrieto Mena, DanielCantera, RafaelEgger, BorisLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/31353/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-844http://localhost:8080/xmlui/bitstream/20.500.12008/31353/2/license_urla0ebbeafb9d2ec7cbb19d7137ebc392cMD52license_textlicense_texttext/html; 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- Universidad de la Repúblicafalse |
| spellingShingle | Compartment and cell-type specific hypoxia responses in the developing Drosophila brain Baccino, Martín Drosophila Brain development Hypoxia Neural stem cell Tracheolation |
| status_str | publishedVersion |
| title | Compartment and cell-type specific hypoxia responses in the developing Drosophila brain |
| title_full | Compartment and cell-type specific hypoxia responses in the developing Drosophila brain |
| title_fullStr | Compartment and cell-type specific hypoxia responses in the developing Drosophila brain |
| title_full_unstemmed | Compartment and cell-type specific hypoxia responses in the developing Drosophila brain |
| title_short | Compartment and cell-type specific hypoxia responses in the developing Drosophila brain |
| title_sort | Compartment and cell-type specific hypoxia responses in the developing Drosophila brain |
| topic | Drosophila Brain development Hypoxia Neural stem cell Tracheolation |
| url | https://hdl.handle.net/20.500.12008/31353 |
