Identification of Long Noncoding RNAs Involved in Eyelid Pigmentation of Hereford Cattle
Resumen:
Several ocular pathologies in cattle, such as ocular squamous cell carcinoma and infectious keratoconjunctivitis, have been associated with low pigmentation of the eyelids. The main objective of this study was to analyze the transcriptome of eyelid skin in Hereford cattle using strand-specific RNA sequencing technology to characterize and identify long noncoding RNAs (lncRNAs). We compared the expression of lncRNAs between pigmented and unpigmented eyelids and analyzed the interaction of lncRNAs and putative target genes to reveal the genetic basis underlying eyelid pigmentation in cattle. We predicted 4,937 putative lncRNAs mapped to the bovine reference genome, enriching the catalog of lncRNAs in Bos taurus. We found 27 differentially expressed lncRNAs between pigmented and unpigmented eyelids, suggesting their involvement in eyelid pigmentation. In addition, we revealed potential links between some significant differentially expressed lncRNAs and target mRNAs involved in the immune response and pigmentation. Overall, this study expands the catalog of lncRNAs in cattle and contributes to a better understanding of the biology of eyelid pigmentation.
| 2022 | |
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Beef cattle Eye cancer lncRNAs Noncoding genetic elements Strand-specific RNAseq GENÉTICA BOVINOS ANIMALES NEOPLASIAS DEL OJO ARN LARGO NO CODIFICANTE |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/55051 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| _version_ | 1872865104724230144 |
|---|---|
| author | Jara, Eugenio |
| author2 | Peñagaricano, Francisco Armstrong, Eileen Menezes, Claudia Tardiz, Lucía Rodons, Gastón Iriarte, Andrés |
| author2_role | author author author author author author |
| author_facet | Jara, Eugenio Peñagaricano, Francisco Armstrong, Eileen Menezes, Claudia Tardiz, Lucía Rodons, Gastón Iriarte, Andrés |
| author_role | author |
| bitstream.checksum.fl_str_mv | 6429389a7df7277b72b7924fdc7d47a9 a0ebbeafb9d2ec7cbb19d7137ebc392c 0e79e635ad5d883764003e78793ad1de e7132498e7c1fe99f7096667baa99b25 b59be970c6c7b48a7216c8005c6bc6a6 |
| bitstream.checksumAlgorithm.fl_str_mv | MD5 MD5 MD5 MD5 MD5 |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Jara Eugenio, Universidad de la República (Uruguay). Facultad de Veterinaria. Departamento de Producción Animal, Unidad de Genética y Mejora Animal Peñagaricano Francisco, University of Wisconsin-Madison (E.E:U.U.). Department of Animal and Dairy Sciences Armstrong Eileen, Universidad de la República (Uruguay). Facultad de Veterinaria. Departamento de Producción Animal, Unidad de Genética y Mejora Animal Menezes Claudia, Universidad de la República (Uruguay). Facultad de Veterinaria. Laboratorio de Endocrinología y Metabolismo Animal Tardiz Lucía, Universidad de la República (Uruguay). Facultad de Veterinaria. Departamento de Producción Animal, Unidad de Genética y Mejora Animal Rodons Gastón, Universidad de la República (Uruguay). Facultad de Veterinaria. Departamento de Producción Animal, Unidad de Genética y Mejora Animal Iriarte Andrés, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene, Departamento de Desarrollo Biotecnológico |
| dc.creator.none.fl_str_mv | Jara, Eugenio Peñagaricano, Francisco Armstrong, Eileen Menezes, Claudia Tardiz, Lucía Rodons, Gastón Iriarte, Andrés |
| dc.date.accessioned.none.fl_str_mv | 2026-05-15T14:41:34Z |
| dc.date.available.none.fl_str_mv | 2026-05-15T14:41:34Z |
| dc.date.issued.none.fl_str_mv | 2022 |
| dc.description.abstract.none.fl_txt_mv | Several ocular pathologies in cattle, such as ocular squamous cell carcinoma and infectious keratoconjunctivitis, have been associated with low pigmentation of the eyelids. The main objective of this study was to analyze the transcriptome of eyelid skin in Hereford cattle using strand-specific RNA sequencing technology to characterize and identify long noncoding RNAs (lncRNAs). We compared the expression of lncRNAs between pigmented and unpigmented eyelids and analyzed the interaction of lncRNAs and putative target genes to reveal the genetic basis underlying eyelid pigmentation in cattle. We predicted 4,937 putative lncRNAs mapped to the bovine reference genome, enriching the catalog of lncRNAs in Bos taurus. We found 27 differentially expressed lncRNAs between pigmented and unpigmented eyelids, suggesting their involvement in eyelid pigmentation. In addition, we revealed potential links between some significant differentially expressed lncRNAs and target mRNAs involved in the immune response and pigmentation. Overall, this study expands the catalog of lncRNAs in cattle and contributes to a better understanding of the biology of eyelid pigmentation. |
| dc.format.extent.es.fl_str_mv | 12 p. |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Jara E, Peñagaricano F, Armstrong E y otros. Identification of Long Noncoding RNAs Involved in Eyelid Pigmentation of Hereford Cattle. Frontiers in Genetics [en línea]. 2022;13. 12 p. |
| dc.identifier.doi.none.fl_str_mv | 10.3389/fgene.2022.864567 |
| dc.identifier.eissn.none.fl_str_mv | 1664-8021 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/55051 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | Frontiers Media |
| dc.relation.none.fl_str_mv | Frontiers in Genetics. 2022;13 |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | Beef cattle Eye cancer lncRNAs Noncoding genetic elements Strand-specific RNAseq |
| dc.subject.other.es.fl_str_mv | GENÉTICA BOVINOS ANIMALES NEOPLASIAS DEL OJO ARN LARGO NO CODIFICANTE |
| dc.title.none.fl_str_mv | Identification of Long Noncoding RNAs Involved in Eyelid Pigmentation of Hereford Cattle |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Several ocular pathologies in cattle, such as ocular squamous cell carcinoma and infectious keratoconjunctivitis, have been associated with low pigmentation of the eyelids. The main objective of this study was to analyze the transcriptome of eyelid skin in Hereford cattle using strand-specific RNA sequencing technology to characterize and identify long noncoding RNAs (lncRNAs). We compared the expression of lncRNAs between pigmented and unpigmented eyelids and analyzed the interaction of lncRNAs and putative target genes to reveal the genetic basis underlying eyelid pigmentation in cattle. We predicted 4,937 putative lncRNAs mapped to the bovine reference genome, enriching the catalog of lncRNAs in Bos taurus. We found 27 differentially expressed lncRNAs between pigmented and unpigmented eyelids, suggesting their involvement in eyelid pigmentation. In addition, we revealed potential links between some significant differentially expressed lncRNAs and target mRNAs involved in the immune response and pigmentation. Overall, this study expands the catalog of lncRNAs in cattle and contributes to a better understanding of the biology of eyelid pigmentation. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_e0ebcf34cb69e92d4af4c2a2d5aeb1b1 |
| identifier_str_mv | Jara E, Peñagaricano F, Armstrong E y otros. Identification of Long Noncoding RNAs Involved in Eyelid Pigmentation of Hereford Cattle. Frontiers in Genetics [en línea]. 2022;13. 12 p. 10.3389/fgene.2022.864567 1664-8021 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/55051 |
| publishDate | 2022 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | karina.camps@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Jara Eugenio, Universidad de la República (Uruguay). Facultad de Veterinaria. Departamento de Producción Animal, Unidad de Genética y Mejora AnimalPeñagaricano Francisco, University of Wisconsin-Madison (E.E:U.U.). Department of Animal and Dairy SciencesArmstrong Eileen, Universidad de la República (Uruguay). Facultad de Veterinaria. Departamento de Producción Animal, Unidad de Genética y Mejora AnimalMenezes Claudia, Universidad de la República (Uruguay). Facultad de Veterinaria. Laboratorio de Endocrinología y Metabolismo AnimalTardiz Lucía, Universidad de la República (Uruguay). Facultad de Veterinaria. Departamento de Producción Animal, Unidad de Genética y Mejora AnimalRodons Gastón, Universidad de la República (Uruguay). Facultad de Veterinaria. Departamento de Producción Animal, Unidad de Genética y Mejora AnimalIriarte Andrés, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene, Departamento de Desarrollo Biotecnológico2026-05-15T14:41:34Z2026-05-15T14:41:34Z2022Jara E, Peñagaricano F, Armstrong E y otros. Identification of Long Noncoding RNAs Involved in Eyelid Pigmentation of Hereford Cattle. Frontiers in Genetics [en línea]. 2022;13. 12 p.https://hdl.handle.net/20.500.12008/5505110.3389/fgene.2022.8645671664-8021Several ocular pathologies in cattle, such as ocular squamous cell carcinoma and infectious keratoconjunctivitis, have been associated with low pigmentation of the eyelids. The main objective of this study was to analyze the transcriptome of eyelid skin in Hereford cattle using strand-specific RNA sequencing technology to characterize and identify long noncoding RNAs (lncRNAs). We compared the expression of lncRNAs between pigmented and unpigmented eyelids and analyzed the interaction of lncRNAs and putative target genes to reveal the genetic basis underlying eyelid pigmentation in cattle. We predicted 4,937 putative lncRNAs mapped to the bovine reference genome, enriching the catalog of lncRNAs in Bos taurus. We found 27 differentially expressed lncRNAs between pigmented and unpigmented eyelids, suggesting their involvement in eyelid pigmentation. In addition, we revealed potential links between some significant differentially expressed lncRNAs and target mRNAs involved in the immune response and pigmentation. Overall, this study expands the catalog of lncRNAs in cattle and contributes to a better understanding of the biology of eyelid pigmentation.Submitted by Almiñana María Cecilia (marialminana@gmail.com) on 2026-05-14T17:16:18Z No. of bitstreams: 2 license_rdf: 25630 bytes, checksum: e7132498e7c1fe99f7096667baa99b25 (MD5) Identification of Long Noncoding RNAs.pdf: 25345736 bytes, checksum: b59be970c6c7b48a7216c8005c6bc6a6 (MD5)Approved for entry into archive by Almiñana María Cecilia (marialminana@gmail.com) on 2026-05-15T13:51:32Z (GMT) No. of bitstreams: 2 license_rdf: 25630 bytes, checksum: e7132498e7c1fe99f7096667baa99b25 (MD5) Identification of Long Noncoding RNAs.pdf: 25345736 bytes, checksum: b59be970c6c7b48a7216c8005c6bc6a6 (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2026-05-15T14:41:34Z (GMT). No. of bitstreams: 2 license_rdf: 25630 bytes, checksum: e7132498e7c1fe99f7096667baa99b25 (MD5) Identification of Long Noncoding RNAs.pdf: 25345736 bytes, checksum: b59be970c6c7b48a7216c8005c6bc6a6 (MD5) Previous issue date: 202212 p.application/pdfenengFrontiers MediaFrontiers in Genetics. 2022;13Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)Beef cattleEye cancerlncRNAsNoncoding genetic elementsStrand-specific RNAseqGENÉTICABOVINOSANIMALESNEOPLASIAS DEL OJOARN LARGO NO CODIFICANTEIdentification of Long Noncoding RNAs Involved in Eyelid Pigmentation of Hereford CattleArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaJara, EugenioPeñagaricano, FranciscoArmstrong, EileenMenezes, ClaudiaTardiz, LucíaRodons, GastónIriarte, AndrésLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/55051/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-844http://localhost:8080/xmlui/bitstream/20.500.12008/55051/2/license_urla0ebbeafb9d2ec7cbb19d7137ebc392cMD52license_textlicense_texttext/html; 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públicahttps://udelar.edu.uy/https://www.colibri.udelar.edu.uy/oai/requestkarina.camps@seciu.edu.uyUruguayopendoar:47712026-05-15T14:41:34COLIBRI - Universidad de la Repúblicafalse |
| spellingShingle | Identification of Long Noncoding RNAs Involved in Eyelid Pigmentation of Hereford Cattle Jara, Eugenio Beef cattle Eye cancer lncRNAs Noncoding genetic elements Strand-specific RNAseq GENÉTICA BOVINOS ANIMALES NEOPLASIAS DEL OJO ARN LARGO NO CODIFICANTE |
| status_str | publishedVersion |
| title | Identification of Long Noncoding RNAs Involved in Eyelid Pigmentation of Hereford Cattle |
| title_full | Identification of Long Noncoding RNAs Involved in Eyelid Pigmentation of Hereford Cattle |
| title_fullStr | Identification of Long Noncoding RNAs Involved in Eyelid Pigmentation of Hereford Cattle |
| title_full_unstemmed | Identification of Long Noncoding RNAs Involved in Eyelid Pigmentation of Hereford Cattle |
| title_short | Identification of Long Noncoding RNAs Involved in Eyelid Pigmentation of Hereford Cattle |
| title_sort | Identification of Long Noncoding RNAs Involved in Eyelid Pigmentation of Hereford Cattle |
| topic | Beef cattle Eye cancer lncRNAs Noncoding genetic elements Strand-specific RNAseq GENÉTICA BOVINOS ANIMALES NEOPLASIAS DEL OJO ARN LARGO NO CODIFICANTE |
| url | https://hdl.handle.net/20.500.12008/55051 |
