Can changes in implant macrogeometry accelerate the osseointegration process?: An in vivo experimental biomechanical and histological evaluations

Gehrke, S.A. - Aramburú Júnior, J. - Pérez-Díaz, Leticia - Dias do Prado, T. - Dedavid, B.A. - Mazón, P. - De Aza, P.N.

Editor(es): Pérez, M.A.

Resumen:

Objectives The propose was to compare this new implant macrogeometry with a control implant with a conventional macrogeometry. Materials and methods Eighty-six conical implants were divided in two groups (n = 43 per group): group control (group CON) that were used conical implants with a conventional macrogeometry and, group test (group TEST) that were used implants with the new macrogeometry. The new implant macrogeometry show several circular healing cambers between the threads, distributed in the implant body. Three implants of each group were used to scanning electronic microscopy (SEM) analysis and, other eighty samples (n = 40 per group) were inserted the tibia of ten rabbit (n = 2 per tibia), determined by randomization. The animals were sacrificed (n = 5 per time) at 3-weeks (Time 1) and at 4-weeks after the implantations (Time 2). The biomechanical evaluation proposed was the measurement of the implant stability quotient (ISQ) and the removal torque values (RTv). The microscopical analysis was a histomorphometric measurement of the bone to implant contact (%BIC) and the SEM evaluation of the bone adhered on the removed implants. Results The results showed that the implants of the group TEST produced a significant enhancement in the osseointegration in comparison with the group CON. The ISQ and RTv tests showed superior values for the group TEST in the both measured times (3- and 4-weeks), with significant differences (p < 0.05). More residual bone in quantity and quality was observed in the samples of the group TEST on the surface of the removed implants. Moreover, the %BIC demonstrated an important increasing for the group TEST in both times, with statistical differences (in Time 1 p = 0.0103 and in Time 2 p < 0.0003). Conclusions Then, we can conclude that the alterations in the implant macrogeometry promote several benefits on the osseointegration process


Detalles Bibliográficos
2020
Experimental implants
Osseointegration
Biomechanical phenomena
Titanium
Prosthesis design
Inglés
Universidad de la República
COLIBRI
https://hdl.handle.net/20.500.12008/31774
Acceso abierto
Licencia Creative Commons Atribución (CC - By 4.0)
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author Gehrke, S.A.
author2 Aramburú Júnior, J.
Pérez-Díaz, Leticia
Dias do Prado, T.
Dedavid, B.A.
Mazón, P.
De Aza, P.N.
author2_role author
author
author
author
author
author
author_facet Gehrke, S.A.
Aramburú Júnior, J.
Pérez-Díaz, Leticia
Dias do Prado, T.
Dedavid, B.A.
Mazón, P.
De Aza, P.N.
author_role author
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dc.contributor.filiacion.none.fl_str_mv Gehrke S.A.
Aramburú Júnior J.
Pérez-Díaz Leticia, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.
Dias do Prado T.
Dedavid B. A.
Mazon P.
De Aza P. N.
dc.creator.editor.none.fl_str_mv Pérez, M.A.
dc.creator.none.fl_str_mv Gehrke, S.A.
Aramburú Júnior, J.
Pérez-Díaz, Leticia
Dias do Prado, T.
Dedavid, B.A.
Mazón, P.
De Aza, P.N.
dc.date.accessioned.none.fl_str_mv 2022-06-01T12:38:52Z
dc.date.available.none.fl_str_mv 2022-06-01T12:38:52Z
dc.date.issued.none.fl_str_mv 2020
dc.description.abstract.none.fl_txt_mv Objectives The propose was to compare this new implant macrogeometry with a control implant with a conventional macrogeometry. Materials and methods Eighty-six conical implants were divided in two groups (n = 43 per group): group control (group CON) that were used conical implants with a conventional macrogeometry and, group test (group TEST) that were used implants with the new macrogeometry. The new implant macrogeometry show several circular healing cambers between the threads, distributed in the implant body. Three implants of each group were used to scanning electronic microscopy (SEM) analysis and, other eighty samples (n = 40 per group) were inserted the tibia of ten rabbit (n = 2 per tibia), determined by randomization. The animals were sacrificed (n = 5 per time) at 3-weeks (Time 1) and at 4-weeks after the implantations (Time 2). The biomechanical evaluation proposed was the measurement of the implant stability quotient (ISQ) and the removal torque values (RTv). The microscopical analysis was a histomorphometric measurement of the bone to implant contact (%BIC) and the SEM evaluation of the bone adhered on the removed implants. Results The results showed that the implants of the group TEST produced a significant enhancement in the osseointegration in comparison with the group CON. The ISQ and RTv tests showed superior values for the group TEST in the both measured times (3- and 4-weeks), with significant differences (p < 0.05). More residual bone in quantity and quality was observed in the samples of the group TEST on the surface of the removed implants. Moreover, the %BIC demonstrated an important increasing for the group TEST in both times, with statistical differences (in Time 1 p = 0.0103 and in Time 2 p < 0.0003). Conclusions Then, we can conclude that the alterations in the implant macrogeometry promote several benefits on the osseointegration process
dc.format.extent.es.fl_str_mv 19 h.
dc.format.mimetype.es.fl_str_mv application/pdf
dc.identifier.citation.es.fl_str_mv Gehrke, S, Aramburú Júnior, J, Pérez-Díaz, L, [y otros] "Can changes in implant macrogeometry accelerate the osseointegration process?: An in vivo experimental biomechanical and histological evaluations". PLos ONE. [en línea] 2020, 15 (5). 19 h. DOI: 10.1371/journal.pone.0233304
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0233304
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12008/31774
dc.language.iso.none.fl_str_mv en
eng
dc.publisher.en.fl_str_mv Public Library of Science
dc.relation.ispartof.es.fl_str_mv PLos ONE, 2020, 15(5): e0233304
dc.rights.license.none.fl_str_mv Licencia Creative Commons Atribución (CC - By 4.0)
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.source.none.fl_str_mv reponame:COLIBRI
instname:Universidad de la República
instacron:Universidad de la República
dc.subject.none.fl_str_mv Experimental implants
Osseointegration
Biomechanical phenomena
Titanium
Prosthesis design
dc.title.none.fl_str_mv Can changes in implant macrogeometry accelerate the osseointegration process?: An in vivo experimental biomechanical and histological evaluations
dc.type.es.fl_str_mv Artículo
dc.type.none.fl_str_mv info:eu-repo/semantics/article
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
description Objectives The propose was to compare this new implant macrogeometry with a control implant with a conventional macrogeometry. Materials and methods Eighty-six conical implants were divided in two groups (n = 43 per group): group control (group CON) that were used conical implants with a conventional macrogeometry and, group test (group TEST) that were used implants with the new macrogeometry. The new implant macrogeometry show several circular healing cambers between the threads, distributed in the implant body. Three implants of each group were used to scanning electronic microscopy (SEM) analysis and, other eighty samples (n = 40 per group) were inserted the tibia of ten rabbit (n = 2 per tibia), determined by randomization. The animals were sacrificed (n = 5 per time) at 3-weeks (Time 1) and at 4-weeks after the implantations (Time 2). The biomechanical evaluation proposed was the measurement of the implant stability quotient (ISQ) and the removal torque values (RTv). The microscopical analysis was a histomorphometric measurement of the bone to implant contact (%BIC) and the SEM evaluation of the bone adhered on the removed implants. Results The results showed that the implants of the group TEST produced a significant enhancement in the osseointegration in comparison with the group CON. The ISQ and RTv tests showed superior values for the group TEST in the both measured times (3- and 4-weeks), with significant differences (p < 0.05). More residual bone in quantity and quality was observed in the samples of the group TEST on the surface of the removed implants. Moreover, the %BIC demonstrated an important increasing for the group TEST in both times, with statistical differences (in Time 1 p = 0.0103 and in Time 2 p < 0.0003). Conclusions Then, we can conclude that the alterations in the implant macrogeometry promote several benefits on the osseointegration process
eu_rights_str_mv openAccess
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identifier_str_mv Gehrke, S, Aramburú Júnior, J, Pérez-Díaz, L, [y otros] "Can changes in implant macrogeometry accelerate the osseointegration process?: An in vivo experimental biomechanical and histological evaluations". PLos ONE. [en línea] 2020, 15 (5). 19 h. DOI: 10.1371/journal.pone.0233304
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10.1371/journal.pone.0233304
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publishDate 2020
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repository.mail.fl_str_mv mabel.seroubian@seciu.edu.uy
repository.name.fl_str_mv COLIBRI - Universidad de la República
repository_id_str 4771
rights_invalid_str_mv Licencia Creative Commons Atribución (CC - By 4.0)
spelling Gehrke S.A.Aramburú Júnior J.Pérez-Díaz Leticia, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Dias do Prado T.Dedavid B. A.Mazon P.De Aza P. N.2022-06-01T12:38:52Z2022-06-01T12:38:52Z2020Gehrke, S, Aramburú Júnior, J, Pérez-Díaz, L, [y otros] "Can changes in implant macrogeometry accelerate the osseointegration process?: An in vivo experimental biomechanical and histological evaluations". PLos ONE. [en línea] 2020, 15 (5). 19 h. DOI: 10.1371/journal.pone.02333041932-6203https://hdl.handle.net/20.500.12008/3177410.1371/journal.pone.0233304Objectives The propose was to compare this new implant macrogeometry with a control implant with a conventional macrogeometry. Materials and methods Eighty-six conical implants were divided in two groups (n = 43 per group): group control (group CON) that were used conical implants with a conventional macrogeometry and, group test (group TEST) that were used implants with the new macrogeometry. The new implant macrogeometry show several circular healing cambers between the threads, distributed in the implant body. Three implants of each group were used to scanning electronic microscopy (SEM) analysis and, other eighty samples (n = 40 per group) were inserted the tibia of ten rabbit (n = 2 per tibia), determined by randomization. The animals were sacrificed (n = 5 per time) at 3-weeks (Time 1) and at 4-weeks after the implantations (Time 2). The biomechanical evaluation proposed was the measurement of the implant stability quotient (ISQ) and the removal torque values (RTv). The microscopical analysis was a histomorphometric measurement of the bone to implant contact (%BIC) and the SEM evaluation of the bone adhered on the removed implants. Results The results showed that the implants of the group TEST produced a significant enhancement in the osseointegration in comparison with the group CON. The ISQ and RTv tests showed superior values for the group TEST in the both measured times (3- and 4-weeks), with significant differences (p < 0.05). More residual bone in quantity and quality was observed in the samples of the group TEST on the surface of the removed implants. Moreover, the %BIC demonstrated an important increasing for the group TEST in both times, with statistical differences (in Time 1 p = 0.0103 and in Time 2 p < 0.0003). Conclusions Then, we can conclude that the alterations in the implant macrogeometry promote several benefits on the osseointegration processSubmitted by Verdun Juan Pablo (jverdun@fcien.edu.uy) on 2022-05-30T22:50:10Z No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 10.1371journal.pone.0233304.pdf: 4661498 bytes, checksum: 0ea22af995b5c339006a5e1d5a3d6c93 (MD5)Approved for entry into archive by Faget Cecilia (lfaget@fcien.edu.uy) on 2022-06-01T12:33:06Z (GMT) No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 10.1371journal.pone.0233304.pdf: 4661498 bytes, checksum: 0ea22af995b5c339006a5e1d5a3d6c93 (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2022-06-01T12:38:52Z (GMT). No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 10.1371journal.pone.0233304.pdf: 4661498 bytes, checksum: 0ea22af995b5c339006a5e1d5a3d6c93 (MD5) Previous issue date: 202019 h.application/pdfenengPublic Library of SciencePLos ONE, 2020, 15(5): e0233304Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)Experimental implantsOsseointegrationBiomechanical phenomenaTitaniumProsthesis designCan changes in implant macrogeometry accelerate the osseointegration process?: An in vivo experimental biomechanical and histological evaluationsArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaGehrke, S.A.Aramburú Júnior, J.Pérez-Díaz, LeticiaDias do Prado, T.Dedavid, B.A.Mazón, P.De Aza, P.N.Pérez, M.A.LICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/31774/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-844http://localhost:8080/xmlui/bitstream/20.500.12008/31774/2/license_urla0ebbeafb9d2ec7cbb19d7137ebc392cMD52license_textlicense_texttext/html; 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- Universidad de la Repúblicafalse
spellingShingle Can changes in implant macrogeometry accelerate the osseointegration process?: An in vivo experimental biomechanical and histological evaluations
Gehrke, S.A.
Experimental implants
Osseointegration
Biomechanical phenomena
Titanium
Prosthesis design
status_str publishedVersion
title Can changes in implant macrogeometry accelerate the osseointegration process?: An in vivo experimental biomechanical and histological evaluations
title_full Can changes in implant macrogeometry accelerate the osseointegration process?: An in vivo experimental biomechanical and histological evaluations
title_fullStr Can changes in implant macrogeometry accelerate the osseointegration process?: An in vivo experimental biomechanical and histological evaluations
title_full_unstemmed Can changes in implant macrogeometry accelerate the osseointegration process?: An in vivo experimental biomechanical and histological evaluations
title_short Can changes in implant macrogeometry accelerate the osseointegration process?: An in vivo experimental biomechanical and histological evaluations
title_sort Can changes in implant macrogeometry accelerate the osseointegration process?: An in vivo experimental biomechanical and histological evaluations
topic Experimental implants
Osseointegration
Biomechanical phenomena
Titanium
Prosthesis design
url https://hdl.handle.net/20.500.12008/31774