Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks
Resumen:
Hypermutable strains of Drosophila simulans have been studied for 20 years. Several mutants were isolated and characterized, some of which had phenotypes associated with alteration in development; for example, showing ectopic legs with eyes being expressed in place of antennae. The causal agent of this hypermutability is a non-autonomous hobo-related sequence (hoboVA). Around 100 mobilizable copies of this element are present in the D. simulans genome, and these are likely mobilized by the autonomous and canonical hobo element. We have shown that hoboVA has transcription factor binding sites for the developmental genes, hunchback and evenskipped, and that this transposon is expressed in embryos, following the patterns of these genes. We suggest that hobo and hobo-related elements can be material for the emergence of new regulatory networks.
| 2018 | |
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Cis-regulatory sequences Drosophila Hobo Transposable elements |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/26260 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| _version_ | 1807522783733743616 |
|---|---|
| author | Loreto, Elgion L. S. |
| author2 | Deprá, Maríndia Diesel, José F. Panzera Crespo, Yanina Valente-Gaiesky, Vera Lucía S. |
| author2_role | author author author author |
| author_facet | Loreto, Elgion L. S. Deprá, Maríndia Diesel, José F. Panzera Crespo, Yanina Valente-Gaiesky, Vera Lucía S. |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Loreto Elgion L. S., Universidad Federal de Rio Grande do Sul (Brasil) Deprá Maríndia, Universidad Federal de Santa Maria (Brasil) Diesel José F., Universidad Federal de Rio Grande do Sul (Brasil) Panzera Yanina, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología Valente-Gaiesky Vera Lucía S., Universidad Federal de Rio Grande do Sul (Brasil) |
| dc.creator.none.fl_str_mv | Loreto, Elgion L. S. Deprá, Maríndia Diesel, José F. Panzera Crespo, Yanina Valente-Gaiesky, Vera Lucía S. |
| dc.date.accessioned.none.fl_str_mv | 2020-12-30T13:37:41Z |
| dc.date.available.none.fl_str_mv | 2020-12-30T13:37:41Z |
| dc.date.issued.none.fl_str_mv | 2018 |
| dc.description.abstract.none.fl_txt_mv | Hypermutable strains of Drosophila simulans have been studied for 20 years. Several mutants were isolated and characterized, some of which had phenotypes associated with alteration in development; for example, showing ectopic legs with eyes being expressed in place of antennae. The causal agent of this hypermutability is a non-autonomous hobo-related sequence (hoboVA). Around 100 mobilizable copies of this element are present in the D. simulans genome, and these are likely mobilized by the autonomous and canonical hobo element. We have shown that hoboVA has transcription factor binding sites for the developmental genes, hunchback and evenskipped, and that this transposon is expressed in embryos, following the patterns of these genes. We suggest that hobo and hobo-related elements can be material for the emergence of new regulatory networks. |
| dc.format.extent.es.fl_str_mv | 8 h. |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Loreto, E., Deprá, M., Diesel, J., y otros. "Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks". Genetics and Molecular Biology. [en línea] 2018, 41(1): 198-205. 8 h. |
| dc.identifier.doi.none.fl_str_mv | 10.1590/1678-4685-GMB-2017-0068 |
| dc.identifier.issn.none.fl_str_mv | 1415-4757 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/26260 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | Brazilian Journal of Genetics |
| dc.relation.ispartof.es.fl_str_mv | Genetics and Molecular Biology, 2018, 41(1): 198-205. |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | Cis-regulatory sequences Drosophila Hobo Transposable elements |
| dc.title.none.fl_str_mv | Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Hypermutable strains of Drosophila simulans have been studied for 20 years. Several mutants were isolated and characterized, some of which had phenotypes associated with alteration in development; for example, showing ectopic legs with eyes being expressed in place of antennae. The causal agent of this hypermutability is a non-autonomous hobo-related sequence (hoboVA). Around 100 mobilizable copies of this element are present in the D. simulans genome, and these are likely mobilized by the autonomous and canonical hobo element. We have shown that hoboVA has transcription factor binding sites for the developmental genes, hunchback and evenskipped, and that this transposon is expressed in embryos, following the patterns of these genes. We suggest that hobo and hobo-related elements can be material for the emergence of new regulatory networks. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_d7c7a7c8b0283e8109cb0af544e77c2b |
| identifier_str_mv | Loreto, E., Deprá, M., Diesel, J., y otros. "Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks". Genetics and Molecular Biology. [en línea] 2018, 41(1): 198-205. 8 h. 1415-4757 10.1590/1678-4685-GMB-2017-0068 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/26260 |
| publishDate | 2018 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | mabel.seroubian@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Loreto Elgion L. S., Universidad Federal de Rio Grande do Sul (Brasil)Deprá Maríndia, Universidad Federal de Santa Maria (Brasil)Diesel José F., Universidad Federal de Rio Grande do Sul (Brasil)Panzera Yanina, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de BiologíaValente-Gaiesky Vera Lucía S., Universidad Federal de Rio Grande do Sul (Brasil)2020-12-30T13:37:41Z2020-12-30T13:37:41Z2018Loreto, E., Deprá, M., Diesel, J., y otros. "Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks". Genetics and Molecular Biology. [en línea] 2018, 41(1): 198-205. 8 h.1415-4757https://hdl.handle.net/20.500.12008/2626010.1590/1678-4685-GMB-2017-0068 Hypermutable strains of Drosophila simulans have been studied for 20 years. Several mutants were isolated and characterized, some of which had phenotypes associated with alteration in development; for example, showing ectopic legs with eyes being expressed in place of antennae. The causal agent of this hypermutability is a non-autonomous hobo-related sequence (hoboVA). Around 100 mobilizable copies of this element are present in the D. simulans genome, and these are likely mobilized by the autonomous and canonical hobo element. We have shown that hoboVA has transcription factor binding sites for the developmental genes, hunchback and evenskipped, and that this transposon is expressed in embryos, following the patterns of these genes. We suggest that hobo and hobo-related elements can be material for the emergence of new regulatory networks.Submitted by Parodi Mónica (mparodi@fcien.edu.uy) on 2020-12-29T17:17:33Z No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 10159016784685GMB20170068.pdf: 2105929 bytes, checksum: e9c08de03b0b55c392d723667dc2dc20 (MD5)Approved for entry into archive by Faget Cecilia (lfaget@fcien.edu.uy) on 2020-12-30T13:13:12Z (GMT) No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 10159016784685GMB20170068.pdf: 2105929 bytes, checksum: e9c08de03b0b55c392d723667dc2dc20 (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@fic.edu.uy) on 2020-12-30T13:37:41Z (GMT). No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 10159016784685GMB20170068.pdf: 2105929 bytes, checksum: e9c08de03b0b55c392d723667dc2dc20 (MD5) Previous issue date: 20188 h.application/pdfenengBrazilian Journal of GeneticsGenetics and Molecular Biology, 2018, 41(1): 198-205.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)Cis-regulatory sequencesDrosophilaHoboTransposable elementsDrosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networksArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaLoreto, Elgion L. 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- Universidad de la Repúblicafalse |
| spellingShingle | Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks Loreto, Elgion L. S. Cis-regulatory sequences Drosophila Hobo Transposable elements |
| status_str | publishedVersion |
| title | Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks |
| title_full | Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks |
| title_fullStr | Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks |
| title_full_unstemmed | Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks |
| title_short | Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks |
| title_sort | Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks |
| topic | Cis-regulatory sequences Drosophila Hobo Transposable elements |
| url | https://hdl.handle.net/20.500.12008/26260 |
