Comparison between Manual and Automated Methods for Ki-67 Immunoexpression Quantification in Ameloblastomas
Resumen:
Ameloblastoma is a common and unpredictable odontogenic tumor with high relapse rates. Several studies assessing the proliferative capacity of these neoplasms have been published, mainly using the protein Ki-67. Cell counts must be completed to determine the cell proliferation rate. Multiple methods have been developed for this purpose.The most widely used method is the labeling index, which has undergone changes over time to better facilitate cell counting. Here, we compared manual cell counting methods with automated cell counting (ImmunoRatio) to determine the relative effectiveness of thesemethods.The results suggest that ImmunoRatio, a free software tool, may be highly advantageous and provide results similar to manual cell counting methods when used with the appropriate calibration. However, ImmunoRatio has flaws that may affect the labeling index results.Therefore, this automated cell counting method must be supplemented with manual cell counting methods.
| 2016 | |
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AMELOBLASTOMA RECUENTO DE CELULAS ANTIGENO Ki-67 AUTOMATIZACION COLORACION Y ETIQUETADO |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/31444 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0) |
| _version_ | 1807522952928821248 |
|---|---|
| author | González González, Rogelio |
| author2 | Molina Frechero, Nelly Carreón Burciaga, Ramón Gil López Verdínnell Bologna-Molina4, Sandra5 Robles Bonilla, Carlos Pereira-Prado, Vanesa Bologna-Molina, Ronell |
| author2_role | author author author author author author |
| author_facet | González González, Rogelio Molina Frechero, Nelly Carreón Burciaga, Ramón Gil López Verdínnell Bologna-Molina4, Sandra5 Robles Bonilla, Carlos Pereira-Prado, Vanesa Bologna-Molina, Ronell |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | González González Rogelio, Department of Research, School of Dentistry, Universidad Ju´arez del Estado de Durango, Durango, DGO, Mexico Molina Frechero Nelly, 2Department of Health Care, Universidad Autónoma Metropolitana, Unidad Xochimilco,Mexico City, Mexico Carreón Burciaga Ramon Gil, Department of Research, School of Dentistry, Universidad Ju´arez del Estado de Durango, Durango, DGO, Mexico López Verdínnell Bologna-Molina4 Sandra5, Microbiology and Pathology Department, Dentistry Research Institute, Health Sciences University Center, Universidad de Guadalajara, Guadalajara, JAL, Mexico Robles Bonilla Carlos, 4School of Health Sciences, Universidad Anahuac Norte, Lomas An´ahuac, Huixquilucan, MEX, Mexico Pereira-Prado Vanesa, Department of Molecular Pathology, School of Dentistry, Universidad de la Rep´ublica, Uruguay, Montevideo, Uruguay Bologna-Molina Ronell, School of Health Sciences, Universidad Anahuac Norte, Lomas An´ahuac, Huixquilucan, MEX, Mexico 5Department of Molecular Pathology, School of Dentistry, Universidad de la Rep´ublica, Uruguay, Montevideo, Uruguay |
| dc.creator.none.fl_str_mv | González González, Rogelio Molina Frechero, Nelly Carreón Burciaga, Ramón Gil López Verdínnell Bologna-Molina4, Sandra5 Robles Bonilla, Carlos Pereira-Prado, Vanesa Bologna-Molina, Ronell |
| dc.date.accessioned.none.fl_str_mv | 2022-05-05T15:25:55Z |
| dc.date.available.none.fl_str_mv | 2022-05-05T15:25:55Z |
| dc.date.issued.none.fl_str_mv | 2016 |
| dc.description.abstract.none.fl_txt_mv | Ameloblastoma is a common and unpredictable odontogenic tumor with high relapse rates. Several studies assessing the proliferative capacity of these neoplasms have been published, mainly using the protein Ki-67. Cell counts must be completed to determine the cell proliferation rate. Multiple methods have been developed for this purpose.The most widely used method is the labeling index, which has undergone changes over time to better facilitate cell counting. Here, we compared manual cell counting methods with automated cell counting (ImmunoRatio) to determine the relative effectiveness of thesemethods.The results suggest that ImmunoRatio, a free software tool, may be highly advantageous and provide results similar to manual cell counting methods when used with the appropriate calibration. However, ImmunoRatio has flaws that may affect the labeling index results.Therefore, this automated cell counting method must be supplemented with manual cell counting methods. |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | González González, R, Molina Frechero, N, Carreón Burciaga, R. "Comparison between Manual and Automated Methods for Ki-67 Immunoexpression Quantification in Ameloblastomas"Analytical Cellular Pathology Volume 2016 [en línea] 2016. dx.doi.org/10.1155/2016/7486989 |
| dc.identifier.doi.none.fl_str_mv | dx.doi.org/10.1155/2016/7486989 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/31444 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.relation.ispartof.es.fl_str_mv | Analytical Cellular Pathology Volume 2016 |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.other.es.fl_str_mv | AMELOBLASTOMA RECUENTO DE CELULAS ANTIGENO Ki-67 AUTOMATIZACION COLORACION Y ETIQUETADO |
| dc.title.none.fl_str_mv | Comparison between Manual and Automated Methods for Ki-67 Immunoexpression Quantification in Ameloblastomas |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Ameloblastoma is a common and unpredictable odontogenic tumor with high relapse rates. Several studies assessing the proliferative capacity of these neoplasms have been published, mainly using the protein Ki-67. Cell counts must be completed to determine the cell proliferation rate. Multiple methods have been developed for this purpose.The most widely used method is the labeling index, which has undergone changes over time to better facilitate cell counting. Here, we compared manual cell counting methods with automated cell counting (ImmunoRatio) to determine the relative effectiveness of thesemethods.The results suggest that ImmunoRatio, a free software tool, may be highly advantageous and provide results similar to manual cell counting methods when used with the appropriate calibration. However, ImmunoRatio has flaws that may affect the labeling index results.Therefore, this automated cell counting method must be supplemented with manual cell counting methods. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_d7b8a28969fecd0df7b0adebfa1cec68 |
| identifier_str_mv | González González, R, Molina Frechero, N, Carreón Burciaga, R. "Comparison between Manual and Automated Methods for Ki-67 Immunoexpression Quantification in Ameloblastomas"Analytical Cellular Pathology Volume 2016 [en línea] 2016. dx.doi.org/10.1155/2016/7486989 dx.doi.org/10.1155/2016/7486989 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/31444 |
| publishDate | 2016 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | mabel.seroubian@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0) |
| spelling | González González Rogelio, Department of Research, School of Dentistry, Universidad Ju´arez del Estado de Durango, Durango, DGO, MexicoMolina Frechero Nelly, 2Department of Health Care, Universidad Autónoma Metropolitana, Unidad Xochimilco,Mexico City, MexicoCarreón Burciaga Ramon Gil, Department of Research, School of Dentistry, Universidad Ju´arez del Estado de Durango, Durango, DGO, MexicoLópez Verdínnell Bologna-Molina4 Sandra5, Microbiology and Pathology Department, Dentistry Research Institute, Health Sciences University Center, Universidad de Guadalajara, Guadalajara, JAL, MexicoRobles Bonilla Carlos, 4School of Health Sciences, Universidad Anahuac Norte, Lomas An´ahuac, Huixquilucan, MEX, MexicoPereira-Prado Vanesa, Department of Molecular Pathology, School of Dentistry, Universidad de la Rep´ublica, Uruguay, Montevideo, UruguayBologna-Molina Ronell, School of Health Sciences, Universidad Anahuac Norte, Lomas An´ahuac, Huixquilucan, MEX, Mexico 5Department of Molecular Pathology, School of Dentistry, Universidad de la Rep´ublica, Uruguay, Montevideo, Uruguay2022-05-05T15:25:55Z2022-05-05T15:25:55Z2016González González, R, Molina Frechero, N, Carreón Burciaga, R. "Comparison between Manual and Automated Methods for Ki-67 Immunoexpression Quantification in Ameloblastomas"Analytical Cellular Pathology Volume 2016 [en línea] 2016. dx.doi.org/10.1155/2016/7486989https://hdl.handle.net/20.500.12008/31444dx.doi.org/10.1155/2016/7486989Ameloblastoma is a common and unpredictable odontogenic tumor with high relapse rates. Several studies assessing the proliferative capacity of these neoplasms have been published, mainly using the protein Ki-67. Cell counts must be completed to determine the cell proliferation rate. Multiple methods have been developed for this purpose.The most widely used method is the labeling index, which has undergone changes over time to better facilitate cell counting. Here, we compared manual cell counting methods with automated cell counting (ImmunoRatio) to determine the relative effectiveness of thesemethods.The results suggest that ImmunoRatio, a free software tool, may be highly advantageous and provide results similar to manual cell counting methods when used with the appropriate calibration. However, ImmunoRatio has flaws that may affect the labeling index results.Therefore, this automated cell counting method must be supplemented with manual cell counting methods.Submitted by Pérez Verónica (verosil22@gmail.com) on 2022-05-05T15:24:13Z No. of bitstreams: 2 license_rdf: 21687 bytes, checksum: 749156fd3854beb422ddf543c77fb5b1 (MD5) Comparision between manual and automated methods for ki-67 immunoexpression quantification in ameloblastomas.pdf: 5196312 bytes, checksum: 8a15ce280873d0552497f2b4a879de7e (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2022-05-05T15:25:55Z (GMT). No. of bitstreams: 2 license_rdf: 21687 bytes, checksum: 749156fd3854beb422ddf543c77fb5b1 (MD5) Comparision between manual and automated methods for ki-67 immunoexpression quantification in ameloblastomas.pdf: 5196312 bytes, checksum: 8a15ce280873d0552497f2b4a879de7e (MD5) Previous issue date: 2016application/pdfenengAnalytical Cellular Pathology Volume 2016Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0)AMELOBLASTOMARECUENTO DE CELULASANTIGENO Ki-67AUTOMATIZACIONCOLORACION Y ETIQUETADOComparison between Manual and Automated Methods for Ki-67 Immunoexpression Quantification in AmeloblastomasArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaGonzález González, RogelioMolina Frechero, NellyCarreón Burciaga, Ramón GilLópez Verdínnell Bologna-Molina4, Sandra5Robles Bonilla, CarlosPereira-Prado, VanesaBologna-Molina, RonellLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/31444/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-847http://localhost:8080/xmlui/bitstream/20.500.12008/31444/2/license_url966d4a1cc97b2c4389b5142dd97d3c7fMD52license_textlicense_texttext/html; charset=utf-838397http://localhost:8080/xmlui/bitstream/20.500.12008/31444/3/license_text67766c36f7a6499ed8d632815eabc281MD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-821687http://localhost:8080/xmlui/bitstream/20.500.12008/31444/4/license_rdf749156fd3854beb422ddf543c77fb5b1MD54ORIGINALComparision between manual and automated methods for ki-67 immunoexpression quantification in ameloblastomas.pdfComparision between manual and automated methods for ki-67 immunoexpression quantification in ameloblastomas.pdfapplication/pdf5196312http://localhost:8080/xmlui/bitstream/20.500.12008/31444/1/Comparision+between+manual+and+automated+methods+for+ki-67+immunoexpression+quantification+in+ameloblastomas.pdf8a15ce280873d0552497f2b4a879de7eMD5120.500.12008/314442024-03-15 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- Universidad de la Repúblicafalse |
| spellingShingle | Comparison between Manual and Automated Methods for Ki-67 Immunoexpression Quantification in Ameloblastomas González González, Rogelio AMELOBLASTOMA RECUENTO DE CELULAS ANTIGENO Ki-67 AUTOMATIZACION COLORACION Y ETIQUETADO |
| status_str | publishedVersion |
| title | Comparison between Manual and Automated Methods for Ki-67 Immunoexpression Quantification in Ameloblastomas |
| title_full | Comparison between Manual and Automated Methods for Ki-67 Immunoexpression Quantification in Ameloblastomas |
| title_fullStr | Comparison between Manual and Automated Methods for Ki-67 Immunoexpression Quantification in Ameloblastomas |
| title_full_unstemmed | Comparison between Manual and Automated Methods for Ki-67 Immunoexpression Quantification in Ameloblastomas |
| title_short | Comparison between Manual and Automated Methods for Ki-67 Immunoexpression Quantification in Ameloblastomas |
| title_sort | Comparison between Manual and Automated Methods for Ki-67 Immunoexpression Quantification in Ameloblastomas |
| topic | AMELOBLASTOMA RECUENTO DE CELULAS ANTIGENO Ki-67 AUTOMATIZACION COLORACION Y ETIQUETADO |
| url | https://hdl.handle.net/20.500.12008/31444 |
