Antiprotozoal compounds from Urolepis hecatantha (Asteraceae)
Resumen:
The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes and Leishmania infantum promastigotes. The extract of U. hecatantha showed activity against both parasites with IC50 values of 7 µg/mL and 31 µg/mL, respectively. Fractionation of the dichloromethane extract led to the isolation of euparin, jaceidin, santhemoidin C, and eucannabinolide. The sesquiterpene lactones eucannabinolide and santhemoidin C were active on T. cruzi with IC50 values of 10 ± 2 µM (4.2 µg/mL) and 18 ± 3 µM (7.6 µg/mL), respectively. Euparin and santhemoidin C were the most active on L. infantum with IC50 values of 18 ± 4 µM (3.9 µg/mL) and 19 ± 4 µM (8.0 µg/mL), respectively. Eucannabinolide has also shown drug-like pharmacokinetic and toxicity properties.
| 2021 | |
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Urolepis hecatantha Asteraceae Antiprotozoal compounds Trypanosoma cruzi Leishmania infantum |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/35746 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| _version_ | 1807522794778394624 |
|---|---|
| author | Elso, Orlando G |
| author2 | Clavin, Maria Hernandez, Natalia Sgarlata, Tomás Bach, Hernán Catalan, César A N Aguilera, Elena Álvarez, Guzmán Sülsen, Valeria P |
| author2_role | author author author author author author author author |
| author_facet | Elso, Orlando G Clavin, Maria Hernandez, Natalia Sgarlata, Tomás Bach, Hernán Catalan, César A N Aguilera, Elena Álvarez, Guzmán Sülsen, Valeria P |
| author_role | author |
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| bitstream.checksumAlgorithm.fl_str_mv | MD5 MD5 MD5 MD5 MD5 |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Elso Orlando G Clavin Maria Hernandez Natalia Sgarlata Tomás Bach Hernán Catalan César A N Aguilera Elena, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. Álvarez Guzmán Sülsen Valeria P |
| dc.creator.none.fl_str_mv | Elso, Orlando G Clavin, Maria Hernandez, Natalia Sgarlata, Tomás Bach, Hernán Catalan, César A N Aguilera, Elena Álvarez, Guzmán Sülsen, Valeria P |
| dc.date.accessioned.none.fl_str_mv | 2023-02-08T14:37:21Z |
| dc.date.available.none.fl_str_mv | 2023-02-08T14:37:21Z |
| dc.date.issued.none.fl_str_mv | 2021 |
| dc.description.abstract.none.fl_txt_mv | The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes and Leishmania infantum promastigotes. The extract of U. hecatantha showed activity against both parasites with IC50 values of 7 µg/mL and 31 µg/mL, respectively. Fractionation of the dichloromethane extract led to the isolation of euparin, jaceidin, santhemoidin C, and eucannabinolide. The sesquiterpene lactones eucannabinolide and santhemoidin C were active on T. cruzi with IC50 values of 10 ± 2 µM (4.2 µg/mL) and 18 ± 3 µM (7.6 µg/mL), respectively. Euparin and santhemoidin C were the most active on L. infantum with IC50 values of 18 ± 4 µM (3.9 µg/mL) and 19 ± 4 µM (8.0 µg/mL), respectively. Eucannabinolide has also shown drug-like pharmacokinetic and toxicity properties. |
| dc.format.extent.es.fl_str_mv | 7 h |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Elso, O, Clavin, M, Hernandez, N [y otros autores]. "Antiprotozoal compounds from Urolepis hecatantha (Asteraceae)". Evidence-Based Complementary and Alternative Medicine. [en línea] 2021: 6622894. 7 h. DOI: 10.1155/2021/6622894. |
| dc.identifier.doi.none.fl_str_mv | 10.1155/2021/6622894 |
| dc.identifier.issn.none.fl_str_mv | 1741-4288 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/35746 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | Hindawi |
| dc.relation.ispartof.es.fl_str_mv | Evidence-Based Complementary and Alternative Medicine: 2021, 2021: 6622894. |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | Urolepis hecatantha Asteraceae Antiprotozoal compounds Trypanosoma cruzi Leishmania infantum |
| dc.title.none.fl_str_mv | Antiprotozoal compounds from Urolepis hecatantha (Asteraceae) |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes and Leishmania infantum promastigotes. The extract of U. hecatantha showed activity against both parasites with IC50 values of 7 µg/mL and 31 µg/mL, respectively. Fractionation of the dichloromethane extract led to the isolation of euparin, jaceidin, santhemoidin C, and eucannabinolide. The sesquiterpene lactones eucannabinolide and santhemoidin C were active on T. cruzi with IC50 values of 10 ± 2 µM (4.2 µg/mL) and 18 ± 3 µM (7.6 µg/mL), respectively. Euparin and santhemoidin C were the most active on L. infantum with IC50 values of 18 ± 4 µM (3.9 µg/mL) and 19 ± 4 µM (8.0 µg/mL), respectively. Eucannabinolide has also shown drug-like pharmacokinetic and toxicity properties. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_d56c5304491857b71b8c83374f36d1d6 |
| identifier_str_mv | Elso, O, Clavin, M, Hernandez, N [y otros autores]. "Antiprotozoal compounds from Urolepis hecatantha (Asteraceae)". Evidence-Based Complementary and Alternative Medicine. [en línea] 2021: 6622894. 7 h. DOI: 10.1155/2021/6622894. 1741-4288 10.1155/2021/6622894 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/35746 |
| publishDate | 2021 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | mabel.seroubian@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Elso Orlando GClavin MariaHernandez NataliaSgarlata TomásBach HernánCatalan César A NAguilera Elena, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica.Álvarez GuzmánSülsen Valeria P2023-02-08T14:37:21Z2023-02-08T14:37:21Z2021Elso, O, Clavin, M, Hernandez, N [y otros autores]. "Antiprotozoal compounds from Urolepis hecatantha (Asteraceae)". Evidence-Based Complementary and Alternative Medicine. [en línea] 2021: 6622894. 7 h. DOI: 10.1155/2021/6622894.1741-4288https://hdl.handle.net/20.500.12008/3574610.1155/2021/6622894The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes and Leishmania infantum promastigotes. The extract of U. hecatantha showed activity against both parasites with IC50 values of 7 µg/mL and 31 µg/mL, respectively. Fractionation of the dichloromethane extract led to the isolation of euparin, jaceidin, santhemoidin C, and eucannabinolide. The sesquiterpene lactones eucannabinolide and santhemoidin C were active on T. cruzi with IC50 values of 10 ± 2 µM (4.2 µg/mL) and 18 ± 3 µM (7.6 µg/mL), respectively. Euparin and santhemoidin C were the most active on L. infantum with IC50 values of 18 ± 4 µM (3.9 µg/mL) and 19 ± 4 µM (8.0 µg/mL), respectively. Eucannabinolide has also shown drug-like pharmacokinetic and toxicity properties.Submitted by Parodi Mónica (mparodi@fcien.edu.uy) on 2023-01-04T14:58:50Z No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 10115520216622894.pdf: 1280307 bytes, checksum: e8686bd330d943191eb91fa5001dbf60 (MD5)Approved for entry into archive by Faget Cecilia (lfaget@fcien.edu.uy) on 2023-02-08T12:26:03Z (GMT) No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 10115520216622894.pdf: 1280307 bytes, checksum: e8686bd330d943191eb91fa5001dbf60 (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2023-02-08T14:37:21Z (GMT). No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 10115520216622894.pdf: 1280307 bytes, checksum: e8686bd330d943191eb91fa5001dbf60 (MD5) Previous issue date: 20217 happlication/pdfenengHindawiEvidence-Based Complementary and Alternative Medicine: 2021, 2021: 6622894.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)Urolepis hecatanthaAsteraceaeAntiprotozoal compoundsTrypanosoma cruziLeishmania infantumAntiprotozoal compounds from Urolepis hecatantha (Asteraceae)Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaElso, Orlando GClavin, MariaHernandez, NataliaSgarlata, TomásBach, HernánCatalan, César A NAguilera, ElenaÁlvarez, GuzmánSülsen, Valeria PLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/35746/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-844http://localhost:8080/xmlui/bitstream/20.500.12008/35746/2/license_urla0ebbeafb9d2ec7cbb19d7137ebc392cMD52license_textlicense_texttext/html; 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- Universidad de la Repúblicafalse |
| spellingShingle | Antiprotozoal compounds from Urolepis hecatantha (Asteraceae) Elso, Orlando G Urolepis hecatantha Asteraceae Antiprotozoal compounds Trypanosoma cruzi Leishmania infantum |
| status_str | publishedVersion |
| title | Antiprotozoal compounds from Urolepis hecatantha (Asteraceae) |
| title_full | Antiprotozoal compounds from Urolepis hecatantha (Asteraceae) |
| title_fullStr | Antiprotozoal compounds from Urolepis hecatantha (Asteraceae) |
| title_full_unstemmed | Antiprotozoal compounds from Urolepis hecatantha (Asteraceae) |
| title_short | Antiprotozoal compounds from Urolepis hecatantha (Asteraceae) |
| title_sort | Antiprotozoal compounds from Urolepis hecatantha (Asteraceae) |
| topic | Urolepis hecatantha Asteraceae Antiprotozoal compounds Trypanosoma cruzi Leishmania infantum |
| url | https://hdl.handle.net/20.500.12008/35746 |
