Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV
Resumen:
Atherosclerosis is the most fatal cardiovascular disease. As disease progresses, stenoses grow inside the arteries blocking their lumen and altering blood flow. Analysing flow dynamics can provide a deeper insight on the stenosis evolution. In this work, we propose a novel approach which combines ultrasound with Eulerian and Lagrangian descriptors, to analyse blood flow dynamics and fluid transport in stenotic aortic models with morphology, mechanical and optical properties close to those of real arteries. To this end, vorticity, particle residence time (PRT), particle’s final position (FP) and finite time Lyapunov’s exponents (FTLE) were computed from the experimental fluid velocity fields acquired using ultrasonic particle imaging velocimetry (Echo-PIV). For the experiments, CT-images were used to create morphological realistic models of the descending aorta with 0%, 35% and 50% occlusion degree with same mechanical properties as real arteries. Each model was connected to a circuit with a pulsatile programmable pump which mimics physiological flow and pressure conditions. The pulsatile frequency was set to ≈ 0.9 Hz (55 bpm) and the upstream peak Reynolds number (Re) was changed from 1100 to 2000. Flow in the poststenotic region was composed of two main structures: a high velocity jet over the stenosis throat and a recirculation region behind the stenosis where vortex form and shed. We characterized vortex kinematics showing that vortex propagation velocity increases with Re. Moreover, from the FTLE field we identified Lagrangian Coherent Structures (i.e. material barriers) that dictate transport behind the stenosis. The size and strength of those barriers increased with Re and the occlusion degree. Finally, from the PRT and FP, we showed that independently of Re, the same amount of fluid remains on the stenosis over more than a pulsatile period, which combined with large FTLE values may provide an alternative way to understand stenosis growth.
2020 | |
CSIC: I+D 2016 ANII: POS_NAC_2015_1109843 |
|
Lagrangian coherent structures Ultrasound Blood flow dynamics Atherosclerosis |
|
Inglés | |
Universidad de la República | |
COLIBRI | |
https://hdl.handle.net/20.500.12008/41915 | |
Acceso abierto | |
Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
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---|---|
author | Brum, Javier |
author2 | Bernal, Miguel Barrere, Nicasio Negreira, Carlos Cabeza, Cecilia |
author2_role | author author author author |
author_facet | Brum, Javier Bernal, Miguel Barrere, Nicasio Negreira, Carlos Cabeza, Cecilia |
author_role | author |
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collection | COLIBRI |
dc.contributor.filiacion.none.fl_str_mv | Brum Javier, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física. Bernal Miguel Barrere Nicasio, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física. Negreira Carlos, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física. Cabeza Cecilia, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física. |
dc.creator.none.fl_str_mv | Brum, Javier Bernal, Miguel Barrere, Nicasio Negreira, Carlos Cabeza, Cecilia |
dc.date.accessioned.none.fl_str_mv | 2023-12-20T17:03:01Z |
dc.date.available.none.fl_str_mv | 2023-12-20T17:03:01Z |
dc.date.issued.none.fl_str_mv | 2020 |
dc.description.abstract.none.fl_txt_mv | Atherosclerosis is the most fatal cardiovascular disease. As disease progresses, stenoses grow inside the arteries blocking their lumen and altering blood flow. Analysing flow dynamics can provide a deeper insight on the stenosis evolution. In this work, we propose a novel approach which combines ultrasound with Eulerian and Lagrangian descriptors, to analyse blood flow dynamics and fluid transport in stenotic aortic models with morphology, mechanical and optical properties close to those of real arteries. To this end, vorticity, particle residence time (PRT), particle’s final position (FP) and finite time Lyapunov’s exponents (FTLE) were computed from the experimental fluid velocity fields acquired using ultrasonic particle imaging velocimetry (Echo-PIV). For the experiments, CT-images were used to create morphological realistic models of the descending aorta with 0%, 35% and 50% occlusion degree with same mechanical properties as real arteries. Each model was connected to a circuit with a pulsatile programmable pump which mimics physiological flow and pressure conditions. The pulsatile frequency was set to ≈ 0.9 Hz (55 bpm) and the upstream peak Reynolds number (Re) was changed from 1100 to 2000. Flow in the poststenotic region was composed of two main structures: a high velocity jet over the stenosis throat and a recirculation region behind the stenosis where vortex form and shed. We characterized vortex kinematics showing that vortex propagation velocity increases with Re. Moreover, from the FTLE field we identified Lagrangian Coherent Structures (i.e. material barriers) that dictate transport behind the stenosis. The size and strength of those barriers increased with Re and the occlusion degree. Finally, from the PRT and FP, we showed that independently of Re, the same amount of fluid remains on the stenosis over more than a pulsatile period, which combined with large FTLE values may provide an alternative way to understand stenosis growth. |
dc.description.es.fl_txt_mv | Publicado también como: Physics in Medicine & Biology, 2021, 66(5): 055026. DOI: 10.1088/1361-6560/abd670 |
dc.description.sponsorship.none.fl_txt_mv | CSIC: I+D 2016 ANII: POS_NAC_2015_1109843 |
dc.format.extent.es.fl_str_mv | 19 h. |
dc.format.mimetype.es.fl_str_mv | application/pdf |
dc.identifier.citation.es.fl_str_mv | Brum, J, Bernal, M, Barrere, N, [y otros autores]. "Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV" [Preprint]. Publicado en: Physics (Fluid Dynamics). 2020, arXiv:2008.06578, Ago 2020, pp 1-19. |
dc.identifier.doi.none.fl_str_mv | 10.48550/arXiv.2008.06578 |
dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/41915 |
dc.language.iso.none.fl_str_mv | en eng |
dc.relation.ispartof.es.fl_str_mv | Physics (Fluid Dynamics), arXiv:2008.06578, ago 2020, pp 1-19 |
dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
dc.rights.uri.*.fl_str_mv | An error occurred getting the license - uri. |
dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
dc.subject.es.fl_str_mv | Lagrangian coherent structures Ultrasound Blood flow dynamics Atherosclerosis |
dc.title.none.fl_str_mv | Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV |
dc.type.es.fl_str_mv | Preprint |
dc.type.none.fl_str_mv | info:eu-repo/semantics/preprint |
dc.type.version.none.fl_str_mv | info:eu-repo/semantics/submittedVersion |
description | Publicado también como: Physics in Medicine & Biology, 2021, 66(5): 055026. DOI: 10.1088/1361-6560/abd670 |
eu_rights_str_mv | openAccess |
format | preprint |
id | COLIBRI_d3eab4ab9e5af703d373227fa7c4be76 |
identifier_str_mv | Brum, J, Bernal, M, Barrere, N, [y otros autores]. "Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV" [Preprint]. Publicado en: Physics (Fluid Dynamics). 2020, arXiv:2008.06578, Ago 2020, pp 1-19. 10.48550/arXiv.2008.06578 |
instacron_str | Universidad de la República |
institution | Universidad de la República |
instname_str | Universidad de la República |
language | eng |
language_invalid_str_mv | en |
network_acronym_str | COLIBRI |
network_name_str | COLIBRI |
oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/41915 |
publishDate | 2020 |
reponame_str | COLIBRI |
repository.mail.fl_str_mv | mabel.seroubian@seciu.edu.uy |
repository.name.fl_str_mv | COLIBRI - Universidad de la República |
repository_id_str | 4771 |
rights_invalid_str_mv | An error occurred getting the license - uri. Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
spelling | Brum Javier, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física.Bernal MiguelBarrere Nicasio, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física.Negreira Carlos, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física.Cabeza Cecilia, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física.2023-12-20T17:03:01Z2023-12-20T17:03:01Z2020Brum, J, Bernal, M, Barrere, N, [y otros autores]. "Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV" [Preprint]. Publicado en: Physics (Fluid Dynamics). 2020, arXiv:2008.06578, Ago 2020, pp 1-19.https://hdl.handle.net/20.500.12008/4191510.48550/arXiv.2008.06578Publicado también como: Physics in Medicine & Biology, 2021, 66(5): 055026. DOI: 10.1088/1361-6560/abd670Atherosclerosis is the most fatal cardiovascular disease. As disease progresses, stenoses grow inside the arteries blocking their lumen and altering blood flow. Analysing flow dynamics can provide a deeper insight on the stenosis evolution. In this work, we propose a novel approach which combines ultrasound with Eulerian and Lagrangian descriptors, to analyse blood flow dynamics and fluid transport in stenotic aortic models with morphology, mechanical and optical properties close to those of real arteries. To this end, vorticity, particle residence time (PRT), particle’s final position (FP) and finite time Lyapunov’s exponents (FTLE) were computed from the experimental fluid velocity fields acquired using ultrasonic particle imaging velocimetry (Echo-PIV). For the experiments, CT-images were used to create morphological realistic models of the descending aorta with 0%, 35% and 50% occlusion degree with same mechanical properties as real arteries. Each model was connected to a circuit with a pulsatile programmable pump which mimics physiological flow and pressure conditions. The pulsatile frequency was set to ≈ 0.9 Hz (55 bpm) and the upstream peak Reynolds number (Re) was changed from 1100 to 2000. Flow in the poststenotic region was composed of two main structures: a high velocity jet over the stenosis throat and a recirculation region behind the stenosis where vortex form and shed. We characterized vortex kinematics showing that vortex propagation velocity increases with Re. Moreover, from the FTLE field we identified Lagrangian Coherent Structures (i.e. material barriers) that dictate transport behind the stenosis. The size and strength of those barriers increased with Re and the occlusion degree. Finally, from the PRT and FP, we showed that independently of Re, the same amount of fluid remains on the stenosis over more than a pulsatile period, which combined with large FTLE values may provide an alternative way to understand stenosis growth.Submitted by Festari Camila (camifestari@gmail.com) on 2023-12-08T06:34:51Z No. of bitstreams: 2 license_rdf: 25790 bytes, checksum: 489f03e71d39068f329bdec8798bce58 (MD5) 2008.06578.pdf: 3381863 bytes, checksum: 87b74bed5428be6ac1a04e556371aa0b (MD5)Approved for entry into archive by Faget Cecilia (lfaget@fcien.edu.uy) on 2023-12-20T13:33:11Z (GMT) No. of bitstreams: 2 license_rdf: 25790 bytes, checksum: 489f03e71d39068f329bdec8798bce58 (MD5) 2008.06578.pdf: 3381863 bytes, checksum: 87b74bed5428be6ac1a04e556371aa0b (MD5)Made available in DSpace by Seroubian Mabel (mabel.seroubian@seciu.edu.uy) on 2023-12-20T17:03:01Z (GMT). No. of bitstreams: 2 license_rdf: 25790 bytes, checksum: 489f03e71d39068f329bdec8798bce58 (MD5) 2008.06578.pdf: 3381863 bytes, checksum: 87b74bed5428be6ac1a04e556371aa0b (MD5) Previous issue date: 2020CSIC: I+D 2016ANII: POS_NAC_2015_110984319 h.application/pdfenengPhysics (Fluid Dynamics), arXiv:2008.06578, ago 2020, pp 1-19Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)An error occurred getting the license - uri.info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)Lagrangian coherent structuresUltrasoundBlood flow dynamicsAtherosclerosisVortex dynamics and transport phenomena in stenotic aortic models using Echo-PIVPreprintinfo:eu-repo/semantics/preprintinfo:eu-repo/semantics/submittedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaBrum, JavierBernal, MiguelBarrere, NicasioNegreira, CarlosCabeza, CeciliaLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/41915/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-850http://localhost:8080/xmlui/bitstream/20.500.12008/41915/2/license_urla006180e3f5b2ad0b88185d14284c0e0MD52license_textlicense_texttext/html; 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- Universidad de la Repúblicafalse |
spellingShingle | Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV Brum, Javier Lagrangian coherent structures Ultrasound Blood flow dynamics Atherosclerosis |
status_str | submittedVersion |
title | Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV |
title_full | Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV |
title_fullStr | Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV |
title_full_unstemmed | Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV |
title_short | Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV |
title_sort | Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV |
topic | Lagrangian coherent structures Ultrasound Blood flow dynamics Atherosclerosis |
url | https://hdl.handle.net/20.500.12008/41915 |