Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV

Brum, Javier - Bernal, Miguel - Barrere, Nicasio - Negreira, Carlos - Cabeza, Cecilia

Resumen:

Atherosclerosis is the most fatal cardiovascular disease. As disease progresses, stenoses grow inside the arteries blocking their lumen and altering blood flow. Analysing flow dynamics can provide a deeper insight on the stenosis evolution. In this work, we propose a novel approach which combines ultrasound with Eulerian and Lagrangian descriptors, to analyse blood flow dynamics and fluid transport in stenotic aortic models with morphology, mechanical and optical properties close to those of real arteries. To this end, vorticity, particle residence time (PRT), particle’s final position (FP) and finite time Lyapunov’s exponents (FTLE) were computed from the experimental fluid velocity fields acquired using ultrasonic particle imaging velocimetry (Echo-PIV). For the experiments, CT-images were used to create morphological realistic models of the descending aorta with 0%, 35% and 50% occlusion degree with same mechanical properties as real arteries. Each model was connected to a circuit with a pulsatile programmable pump which mimics physiological flow and pressure conditions. The pulsatile frequency was set to ≈ 0.9 Hz (55 bpm) and the upstream peak Reynolds number (Re) was changed from 1100 to 2000. Flow in the poststenotic region was composed of two main structures: a high velocity jet over the stenosis throat and a recirculation region behind the stenosis where vortex form and shed. We characterized vortex kinematics showing that vortex propagation velocity increases with Re. Moreover, from the FTLE field we identified Lagrangian Coherent Structures (i.e. material barriers) that dictate transport behind the stenosis. The size and strength of those barriers increased with Re and the occlusion degree. Finally, from the PRT and FP, we showed that independently of Re, the same amount of fluid remains on the stenosis over more than a pulsatile period, which combined with large FTLE values may provide an alternative way to understand stenosis growth.


Detalles Bibliográficos
2020
CSIC: I+D 2016
ANII: POS_NAC_2015_1109843
Lagrangian coherent structures
Ultrasound
Blood flow dynamics
Atherosclerosis
Inglés
Universidad de la República
COLIBRI
https://hdl.handle.net/20.500.12008/41915
Acceso abierto
Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)
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author Brum, Javier
author2 Bernal, Miguel
Barrere, Nicasio
Negreira, Carlos
Cabeza, Cecilia
author2_role author
author
author
author
author_facet Brum, Javier
Bernal, Miguel
Barrere, Nicasio
Negreira, Carlos
Cabeza, Cecilia
author_role author
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dc.contributor.filiacion.none.fl_str_mv Brum Javier, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física.
Bernal Miguel
Barrere Nicasio, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física.
Negreira Carlos, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física.
Cabeza Cecilia, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física.
dc.creator.none.fl_str_mv Brum, Javier
Bernal, Miguel
Barrere, Nicasio
Negreira, Carlos
Cabeza, Cecilia
dc.date.accessioned.none.fl_str_mv 2023-12-20T17:03:01Z
dc.date.available.none.fl_str_mv 2023-12-20T17:03:01Z
dc.date.issued.none.fl_str_mv 2020
dc.description.abstract.none.fl_txt_mv Atherosclerosis is the most fatal cardiovascular disease. As disease progresses, stenoses grow inside the arteries blocking their lumen and altering blood flow. Analysing flow dynamics can provide a deeper insight on the stenosis evolution. In this work, we propose a novel approach which combines ultrasound with Eulerian and Lagrangian descriptors, to analyse blood flow dynamics and fluid transport in stenotic aortic models with morphology, mechanical and optical properties close to those of real arteries. To this end, vorticity, particle residence time (PRT), particle’s final position (FP) and finite time Lyapunov’s exponents (FTLE) were computed from the experimental fluid velocity fields acquired using ultrasonic particle imaging velocimetry (Echo-PIV). For the experiments, CT-images were used to create morphological realistic models of the descending aorta with 0%, 35% and 50% occlusion degree with same mechanical properties as real arteries. Each model was connected to a circuit with a pulsatile programmable pump which mimics physiological flow and pressure conditions. The pulsatile frequency was set to ≈ 0.9 Hz (55 bpm) and the upstream peak Reynolds number (Re) was changed from 1100 to 2000. Flow in the poststenotic region was composed of two main structures: a high velocity jet over the stenosis throat and a recirculation region behind the stenosis where vortex form and shed. We characterized vortex kinematics showing that vortex propagation velocity increases with Re. Moreover, from the FTLE field we identified Lagrangian Coherent Structures (i.e. material barriers) that dictate transport behind the stenosis. The size and strength of those barriers increased with Re and the occlusion degree. Finally, from the PRT and FP, we showed that independently of Re, the same amount of fluid remains on the stenosis over more than a pulsatile period, which combined with large FTLE values may provide an alternative way to understand stenosis growth.
dc.description.es.fl_txt_mv Publicado también como: Physics in Medicine & Biology, 2021, 66(5): 055026. DOI: 10.1088/1361-6560/abd670
dc.description.sponsorship.none.fl_txt_mv CSIC: I+D 2016
ANII: POS_NAC_2015_1109843
dc.format.extent.es.fl_str_mv 19 h.
dc.format.mimetype.es.fl_str_mv application/pdf
dc.identifier.citation.es.fl_str_mv Brum, J, Bernal, M, Barrere, N, [y otros autores]. "Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV" [Preprint]. Publicado en: Physics (Fluid Dynamics). 2020, arXiv:2008.06578, Ago 2020, pp 1-19.
dc.identifier.doi.none.fl_str_mv 10.48550/arXiv.2008.06578
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12008/41915
dc.language.iso.none.fl_str_mv en
eng
dc.relation.ispartof.es.fl_str_mv Physics (Fluid Dynamics), arXiv:2008.06578, ago 2020, pp 1-19
dc.rights.license.none.fl_str_mv Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.*.fl_str_mv An error occurred getting the license - uri.
dc.source.none.fl_str_mv reponame:COLIBRI
instname:Universidad de la República
instacron:Universidad de la República
dc.subject.es.fl_str_mv Lagrangian coherent structures
Ultrasound
Blood flow dynamics
Atherosclerosis
dc.title.none.fl_str_mv Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV
dc.type.es.fl_str_mv Preprint
dc.type.none.fl_str_mv info:eu-repo/semantics/preprint
dc.type.version.none.fl_str_mv info:eu-repo/semantics/submittedVersion
description Publicado también como: Physics in Medicine & Biology, 2021, 66(5): 055026. DOI: 10.1088/1361-6560/abd670
eu_rights_str_mv openAccess
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identifier_str_mv Brum, J, Bernal, M, Barrere, N, [y otros autores]. "Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV" [Preprint]. Publicado en: Physics (Fluid Dynamics). 2020, arXiv:2008.06578, Ago 2020, pp 1-19.
10.48550/arXiv.2008.06578
instacron_str Universidad de la República
institution Universidad de la República
instname_str Universidad de la República
language eng
language_invalid_str_mv en
network_acronym_str COLIBRI
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publishDate 2020
reponame_str COLIBRI
repository.mail.fl_str_mv mabel.seroubian@seciu.edu.uy
repository.name.fl_str_mv COLIBRI - Universidad de la República
repository_id_str 4771
rights_invalid_str_mv An error occurred getting the license - uri.
Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)
spelling Brum Javier, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física.Bernal MiguelBarrere Nicasio, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física.Negreira Carlos, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física.Cabeza Cecilia, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física.2023-12-20T17:03:01Z2023-12-20T17:03:01Z2020Brum, J, Bernal, M, Barrere, N, [y otros autores]. "Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV" [Preprint]. Publicado en: Physics (Fluid Dynamics). 2020, arXiv:2008.06578, Ago 2020, pp 1-19.https://hdl.handle.net/20.500.12008/4191510.48550/arXiv.2008.06578Publicado también como: Physics in Medicine & Biology, 2021, 66(5): 055026. DOI: 10.1088/1361-6560/abd670Atherosclerosis is the most fatal cardiovascular disease. As disease progresses, stenoses grow inside the arteries blocking their lumen and altering blood flow. Analysing flow dynamics can provide a deeper insight on the stenosis evolution. In this work, we propose a novel approach which combines ultrasound with Eulerian and Lagrangian descriptors, to analyse blood flow dynamics and fluid transport in stenotic aortic models with morphology, mechanical and optical properties close to those of real arteries. To this end, vorticity, particle residence time (PRT), particle’s final position (FP) and finite time Lyapunov’s exponents (FTLE) were computed from the experimental fluid velocity fields acquired using ultrasonic particle imaging velocimetry (Echo-PIV). For the experiments, CT-images were used to create morphological realistic models of the descending aorta with 0%, 35% and 50% occlusion degree with same mechanical properties as real arteries. Each model was connected to a circuit with a pulsatile programmable pump which mimics physiological flow and pressure conditions. The pulsatile frequency was set to ≈ 0.9 Hz (55 bpm) and the upstream peak Reynolds number (Re) was changed from 1100 to 2000. Flow in the poststenotic region was composed of two main structures: a high velocity jet over the stenosis throat and a recirculation region behind the stenosis where vortex form and shed. We characterized vortex kinematics showing that vortex propagation velocity increases with Re. Moreover, from the FTLE field we identified Lagrangian Coherent Structures (i.e. material barriers) that dictate transport behind the stenosis. The size and strength of those barriers increased with Re and the occlusion degree. Finally, from the PRT and FP, we showed that independently of Re, the same amount of fluid remains on the stenosis over more than a pulsatile period, which combined with large FTLE values may provide an alternative way to understand stenosis growth.Submitted by Festari Camila (camifestari@gmail.com) on 2023-12-08T06:34:51Z No. of bitstreams: 2 license_rdf: 25790 bytes, checksum: 489f03e71d39068f329bdec8798bce58 (MD5) 2008.06578.pdf: 3381863 bytes, checksum: 87b74bed5428be6ac1a04e556371aa0b (MD5)Approved for entry into archive by Faget Cecilia (lfaget@fcien.edu.uy) on 2023-12-20T13:33:11Z (GMT) No. of bitstreams: 2 license_rdf: 25790 bytes, checksum: 489f03e71d39068f329bdec8798bce58 (MD5) 2008.06578.pdf: 3381863 bytes, checksum: 87b74bed5428be6ac1a04e556371aa0b (MD5)Made available in DSpace by Seroubian Mabel (mabel.seroubian@seciu.edu.uy) on 2023-12-20T17:03:01Z (GMT). No. of bitstreams: 2 license_rdf: 25790 bytes, checksum: 489f03e71d39068f329bdec8798bce58 (MD5) 2008.06578.pdf: 3381863 bytes, checksum: 87b74bed5428be6ac1a04e556371aa0b (MD5) Previous issue date: 2020CSIC: I+D 2016ANII: POS_NAC_2015_110984319 h.application/pdfenengPhysics (Fluid Dynamics), arXiv:2008.06578, ago 2020, pp 1-19Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)An error occurred getting the license - uri.info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)Lagrangian coherent structuresUltrasoundBlood flow dynamicsAtherosclerosisVortex dynamics and transport phenomena in stenotic aortic models using Echo-PIVPreprintinfo:eu-repo/semantics/preprintinfo:eu-repo/semantics/submittedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaBrum, JavierBernal, MiguelBarrere, NicasioNegreira, CarlosCabeza, CeciliaLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/41915/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-850http://localhost:8080/xmlui/bitstream/20.500.12008/41915/2/license_urla006180e3f5b2ad0b88185d14284c0e0MD52license_textlicense_texttext/html; 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- Universidad de la Repúblicafalse
spellingShingle Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV
Brum, Javier
Lagrangian coherent structures
Ultrasound
Blood flow dynamics
Atherosclerosis
status_str submittedVersion
title Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV
title_full Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV
title_fullStr Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV
title_full_unstemmed Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV
title_short Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV
title_sort Vortex dynamics and transport phenomena in stenotic aortic models using Echo-PIV
topic Lagrangian coherent structures
Ultrasound
Blood flow dynamics
Atherosclerosis
url https://hdl.handle.net/20.500.12008/41915