Effect of 15 BMI-Associated polymorphisms, reported for europeans, across ethnicities and degrees of amerindian ancestry in mexican children
Resumen:
In Mexico, the genetic mechanisms underlying childhood obesity are poorly known. We evaluated the effect of loci, known to be associated with childhood body mass index (BMI) in Europeans, in Mexican children from different ethnic groups. We performed linear and logistic analyses of BMI and obesity, respectively, in Mestizos and Amerindians (Seris, Yaquis and Nahuatl speakers) from Northern (n = 369) and Central Mexico (n = 8545). We used linear models to understand the effect of degree of Amerindian ancestry (AMA) and genetic risk score (GRS) on BMI z-score. Northern Mexican Mestizos showed the highest overweight-obesity prevalence (47.4%), followed by Seri (36.2%) and Central Mexican (31.5%) children. Eleven loci (SEC16B/rs543874, OLFM4/rs12429545/rs9568856, FTO/rs9939609, MC4R/rs6567160, GNPDA2/rs13130484, FAIM2/rs7132908, FAM120AOS/rs944990, LMX1B/rs3829849, ADAM23/rs13387838, HOXB5/rs9299) were associated with BMI and seven (SEC16B/rs543874, OLFM4/rs12429545/rs9568856, FTO/rs9939609, MC4R/rs6567160, GNPDA2 rs13130484, LMX1B/rs3829849) were associated with obesity in Central Mexican children. One SNP was associated with obesity in Northern Mexicans and Yaquis (SEC16B/rs543874). We found higher BMI z-score at higher GRS (β = 0.11, p = 0.2 × 10−16) and at lower AMA (β = −0.05, p = 6.8 × 10−7). The GRS interacts with AMA to increase BMI (β = 0.03, p = 6.08 × 10−3). High genetic BMI susceptibility increase the risk of higher BMI, including in Amerindian children.
| 2020 | |
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Genetic susceptibility BMI Childhood obesity Amerindian ancestry |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/28662 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| _version_ | 1807522787559997440 |
|---|---|
| author | Costa-Urrutia, Paula |
| author2 | Abud Amato, Carolina Franco-Trecu, Valentina Colistro, Valentina Rodríguez-Arellano, M.E. Álvarez-Fariña, R. Acuña Alonso, V. Bertoni, Bernardo Granados, J. |
| author2_role | author author author author author author author author |
| author_facet | Costa-Urrutia, Paula Abud Amato, Carolina Franco-Trecu, Valentina Colistro, Valentina Rodríguez-Arellano, M.E. Álvarez-Fariña, R. Acuña Alonso, V. Bertoni, Bernardo Granados, J. |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Costa-Urrutia Paula Abud Amato Carolina Franco-Trecu Valentina, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Colistro Valentina, Universidad de la República (Uruguay). Facultad de Medicina. Rodríguez-Arellano M.E. Álvarez-Fariña R. Acuña Alonso V. Bertoni Bernardo, Universidad de la República (Uruguay). Facultad de Medicina. Granados J. |
| dc.creator.none.fl_str_mv | Costa-Urrutia, Paula Abud Amato, Carolina Franco-Trecu, Valentina Colistro, Valentina Rodríguez-Arellano, M.E. Álvarez-Fariña, R. Acuña Alonso, V. Bertoni, Bernardo Granados, J. |
| dc.date.accessioned.none.fl_str_mv | 2021-07-22T12:27:09Z |
| dc.date.available.none.fl_str_mv | 2021-07-22T12:27:09Z |
| dc.date.issued.none.fl_str_mv | 2020 |
| dc.description.abstract.none.fl_txt_mv | In Mexico, the genetic mechanisms underlying childhood obesity are poorly known. We evaluated the effect of loci, known to be associated with childhood body mass index (BMI) in Europeans, in Mexican children from different ethnic groups. We performed linear and logistic analyses of BMI and obesity, respectively, in Mestizos and Amerindians (Seris, Yaquis and Nahuatl speakers) from Northern (n = 369) and Central Mexico (n = 8545). We used linear models to understand the effect of degree of Amerindian ancestry (AMA) and genetic risk score (GRS) on BMI z-score. Northern Mexican Mestizos showed the highest overweight-obesity prevalence (47.4%), followed by Seri (36.2%) and Central Mexican (31.5%) children. Eleven loci (SEC16B/rs543874, OLFM4/rs12429545/rs9568856, FTO/rs9939609, MC4R/rs6567160, GNPDA2/rs13130484, FAIM2/rs7132908, FAM120AOS/rs944990, LMX1B/rs3829849, ADAM23/rs13387838, HOXB5/rs9299) were associated with BMI and seven (SEC16B/rs543874, OLFM4/rs12429545/rs9568856, FTO/rs9939609, MC4R/rs6567160, GNPDA2 rs13130484, LMX1B/rs3829849) were associated with obesity in Central Mexican children. One SNP was associated with obesity in Northern Mexicans and Yaquis (SEC16B/rs543874). We found higher BMI z-score at higher GRS (β = 0.11, p = 0.2 × 10−16) and at lower AMA (β = −0.05, p = 6.8 × 10−7). The GRS interacts with AMA to increase BMI (β = 0.03, p = 6.08 × 10−3). High genetic BMI susceptibility increase the risk of higher BMI, including in Amerindian children. |
| dc.format.extent.es.fl_str_mv | 12 h. |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.en.fl_str_mv | Costa-Urrutia, P, Abud Amato, C, Franco-Trecu, V, y otros "Effect of 15 BMI-Associated polymorphisms, reported for europeans, across ethnicities and degrees of amerindian ancestry in mexican children". International Journal of Molecular Sciences. [en línea] 2020, 21(2): 274. 12 h. DOI: 10.3390/ijms21020374 |
| dc.identifier.doi.none.fl_str_mv | 10.3390/ijms21020374 |
| dc.identifier.issn.none.fl_str_mv | 1422-0067 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/28662 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | MDPI |
| dc.relation.ispartof.en.fl_str_mv | International Journal of Molecular Sciences, 2020, 21(2):274 |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.en.fl_str_mv | Genetic susceptibility BMI Childhood obesity Amerindian ancestry |
| dc.title.none.fl_str_mv | Effect of 15 BMI-Associated polymorphisms, reported for europeans, across ethnicities and degrees of amerindian ancestry in mexican children |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | In Mexico, the genetic mechanisms underlying childhood obesity are poorly known. We evaluated the effect of loci, known to be associated with childhood body mass index (BMI) in Europeans, in Mexican children from different ethnic groups. We performed linear and logistic analyses of BMI and obesity, respectively, in Mestizos and Amerindians (Seris, Yaquis and Nahuatl speakers) from Northern (n = 369) and Central Mexico (n = 8545). We used linear models to understand the effect of degree of Amerindian ancestry (AMA) and genetic risk score (GRS) on BMI z-score. Northern Mexican Mestizos showed the highest overweight-obesity prevalence (47.4%), followed by Seri (36.2%) and Central Mexican (31.5%) children. Eleven loci (SEC16B/rs543874, OLFM4/rs12429545/rs9568856, FTO/rs9939609, MC4R/rs6567160, GNPDA2/rs13130484, FAIM2/rs7132908, FAM120AOS/rs944990, LMX1B/rs3829849, ADAM23/rs13387838, HOXB5/rs9299) were associated with BMI and seven (SEC16B/rs543874, OLFM4/rs12429545/rs9568856, FTO/rs9939609, MC4R/rs6567160, GNPDA2 rs13130484, LMX1B/rs3829849) were associated with obesity in Central Mexican children. One SNP was associated with obesity in Northern Mexicans and Yaquis (SEC16B/rs543874). We found higher BMI z-score at higher GRS (β = 0.11, p = 0.2 × 10−16) and at lower AMA (β = −0.05, p = 6.8 × 10−7). The GRS interacts with AMA to increase BMI (β = 0.03, p = 6.08 × 10−3). High genetic BMI susceptibility increase the risk of higher BMI, including in Amerindian children. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_d19ce0a59b7d706ba0bbca104a38f6d7 |
| identifier_str_mv | Costa-Urrutia, P, Abud Amato, C, Franco-Trecu, V, y otros "Effect of 15 BMI-Associated polymorphisms, reported for europeans, across ethnicities and degrees of amerindian ancestry in mexican children". International Journal of Molecular Sciences. [en línea] 2020, 21(2): 274. 12 h. DOI: 10.3390/ijms21020374 1422-0067 10.3390/ijms21020374 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/28662 |
| publishDate | 2020 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | mabel.seroubian@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Costa-Urrutia PaulaAbud Amato CarolinaFranco-Trecu Valentina, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Colistro Valentina, Universidad de la República (Uruguay). Facultad de Medicina.Rodríguez-Arellano M.E.Álvarez-Fariña R.Acuña Alonso V.Bertoni Bernardo, Universidad de la República (Uruguay). Facultad de Medicina.Granados J.2021-07-22T12:27:09Z2021-07-22T12:27:09Z2020Costa-Urrutia, P, Abud Amato, C, Franco-Trecu, V, y otros "Effect of 15 BMI-Associated polymorphisms, reported for europeans, across ethnicities and degrees of amerindian ancestry in mexican children". International Journal of Molecular Sciences. [en línea] 2020, 21(2): 274. 12 h. DOI: 10.3390/ijms210203741422-0067https://hdl.handle.net/20.500.12008/2866210.3390/ijms21020374In Mexico, the genetic mechanisms underlying childhood obesity are poorly known. We evaluated the effect of loci, known to be associated with childhood body mass index (BMI) in Europeans, in Mexican children from different ethnic groups. We performed linear and logistic analyses of BMI and obesity, respectively, in Mestizos and Amerindians (Seris, Yaquis and Nahuatl speakers) from Northern (n = 369) and Central Mexico (n = 8545). We used linear models to understand the effect of degree of Amerindian ancestry (AMA) and genetic risk score (GRS) on BMI z-score. Northern Mexican Mestizos showed the highest overweight-obesity prevalence (47.4%), followed by Seri (36.2%) and Central Mexican (31.5%) children. Eleven loci (SEC16B/rs543874, OLFM4/rs12429545/rs9568856, FTO/rs9939609, MC4R/rs6567160, GNPDA2/rs13130484, FAIM2/rs7132908, FAM120AOS/rs944990, LMX1B/rs3829849, ADAM23/rs13387838, HOXB5/rs9299) were associated with BMI and seven (SEC16B/rs543874, OLFM4/rs12429545/rs9568856, FTO/rs9939609, MC4R/rs6567160, GNPDA2 rs13130484, LMX1B/rs3829849) were associated with obesity in Central Mexican children. One SNP was associated with obesity in Northern Mexicans and Yaquis (SEC16B/rs543874). We found higher BMI z-score at higher GRS (β = 0.11, p = 0.2 × 10−16) and at lower AMA (β = −0.05, p = 6.8 × 10−7). The GRS interacts with AMA to increase BMI (β = 0.03, p = 6.08 × 10−3). High genetic BMI susceptibility increase the risk of higher BMI, including in Amerindian children.Submitted by Verdun Juan Pablo (jverdun@fcien.edu.uy) on 2021-07-08T14:00:00Z No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 10.3390ijms21020374.pdf: 503228 bytes, checksum: 0dc40f8b4f0e5bc38795e877fec37977 (MD5)Approved for entry into archive by Faget Cecilia (lfaget@fcien.edu.uy) on 2021-07-22T12:22:36Z (GMT) No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 10.3390ijms21020374.pdf: 503228 bytes, checksum: 0dc40f8b4f0e5bc38795e877fec37977 (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2021-07-22T12:27:09Z (GMT). No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 10.3390ijms21020374.pdf: 503228 bytes, checksum: 0dc40f8b4f0e5bc38795e877fec37977 (MD5) Previous issue date: 202012 h.application/pdfenengMDPIInternational Journal of Molecular Sciences, 2020, 21(2):274Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)Genetic susceptibilityBMIChildhood obesityAmerindian ancestryEffect of 15 BMI-Associated polymorphisms, reported for europeans, across ethnicities and degrees of amerindian ancestry in mexican childrenArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaCosta-Urrutia, PaulaAbud Amato, CarolinaFranco-Trecu, ValentinaColistro, ValentinaRodríguez-Arellano, M.E.Álvarez-Fariña, R.Acuña Alonso, V.Bertoni, BernardoGranados, J.LICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/28662/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; 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- Universidad de la Repúblicafalse |
| spellingShingle | Effect of 15 BMI-Associated polymorphisms, reported for europeans, across ethnicities and degrees of amerindian ancestry in mexican children Costa-Urrutia, Paula Genetic susceptibility BMI Childhood obesity Amerindian ancestry |
| status_str | publishedVersion |
| title | Effect of 15 BMI-Associated polymorphisms, reported for europeans, across ethnicities and degrees of amerindian ancestry in mexican children |
| title_full | Effect of 15 BMI-Associated polymorphisms, reported for europeans, across ethnicities and degrees of amerindian ancestry in mexican children |
| title_fullStr | Effect of 15 BMI-Associated polymorphisms, reported for europeans, across ethnicities and degrees of amerindian ancestry in mexican children |
| title_full_unstemmed | Effect of 15 BMI-Associated polymorphisms, reported for europeans, across ethnicities and degrees of amerindian ancestry in mexican children |
| title_short | Effect of 15 BMI-Associated polymorphisms, reported for europeans, across ethnicities and degrees of amerindian ancestry in mexican children |
| title_sort | Effect of 15 BMI-Associated polymorphisms, reported for europeans, across ethnicities and degrees of amerindian ancestry in mexican children |
| topic | Genetic susceptibility BMI Childhood obesity Amerindian ancestry |
| url | https://hdl.handle.net/20.500.12008/28662 |
