Dementia in Latin America: Paving the way toward a regional action plan
Resumen:
Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.
| 2021 | |
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Latin America Biomarkers Clinical trials Dementia Epidemiology Evidence-based recommendations Genetics Knowledge to action framework Networking and translational research Nonpharmacological interventions BIOMARCADORES DEMENCIA EPIDEMIOLOGÍA PRÁCTICA CLÍNICA BASADA EN LA EVIDENCIA TERAPÉUTICA HUMANOS FACTORES SOCIOECONÓMICOS |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/55541 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0) |
| _version_ | 1877555262671290368 |
|---|---|
| author | Parra, Mario Alfredo |
| author2 | Baez, Sandra Sedeño, Lucas Gonzalez Campo, Cecilia Damian, Andrés Engler, Henry Willy |
| author2_role | author author author author author |
| author_facet | Parra, Mario Alfredo Baez, Sandra Sedeño, Lucas Gonzalez Campo, Cecilia Damian, Andrés Engler, Henry Willy |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Parra Mario Alfredo, Universidad Autónoma del Caribe (Colombia). Programa de Psicología Baez Sandra, Universidad de los Andes (Colombia) Sedeño Lucas, Consejo Nacional de Investigaciones Científicas y Tecnológicas (Argentina) Gonzalez Campo Cecilia, Universidad de San Andrés (Argentina). Centro de Neurociencias Cognitivas; Consejo Nacional de Investigaciones Científicas y Tecnológicas (Argentina) Damian Andrés, Universidad de la República (Uruguay). Facultad de Medicina. Hospital de Clínicas. Centro Uruguayo de Imagenología Molecular Engler Henry Willy, Universidad de la República (Uruguay). Facultad de Medicina |
| dc.coverage.spatial.es.fl_str_mv | AMÉRICA LATINA |
| dc.creator.none.fl_str_mv | Parra, Mario Alfredo Baez, Sandra Sedeño, Lucas Gonzalez Campo, Cecilia Damian, Andrés Engler, Henry Willy |
| dc.date.accessioned.none.fl_str_mv | 2026-06-16T15:14:01Z |
| dc.date.available.none.fl_str_mv | 2026-06-16T15:14:01Z |
| dc.date.issued.none.fl_str_mv | 2021 |
| dc.description.abstract.none.fl_txt_mv | Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF. |
| dc.description.es.fl_txt_mv | Mario Alfredo Parra 1, Sandra Baez 2, Lucas Sedeño 3, Cecilia Gonzalez Campo 4, Hernando Santamaría-García 5, Ivan Aprahamian 6, Paulo Hf Bertolucci 7, Julian Bustin 8, Maria Aparecida Camargos Bicalho 9, Carlos Cano-Gutierrez 10, Paulo Caramelli 11, Marcia L F Chaves 12, Patricia Cogram 13, Bárbara Costa Beber 14, Felipe A Court 15, Leonardo Cruz de Souza 11, Nilton Custodio 16, Andres Damian 17, Myriam de la Cruz 18, Roberta Diehl Rodriguez 19, Sonia Maria Dozzi Brucki 20, Lais Fajersztajn 21, Gonzalo A Farías 22, Fernanda G De Felice 23, Raffaele Ferrari 24, Fabricio Ferreira de Oliveira 7, Sergio T Ferreira 25, Ceres Ferretti 26, Marcio Luiz Figueredo Balthazar 27, Norberto Anizio Ferreira Frota 28, Patricio Fuentes 29, Adolfo M García 30, Patricia J Garcia 31, Fábio Henrique de Gobbi Porto 32, Lissette Duque Peñailillo 33, Henry Willy Engler 34, Irene Maier 35, Ignacio F Mata 36, Christian Gonzalez-Billault 37, Oscar L Lopez 38, Laura Morelli 39, Ricardo Nitrini 40, Yakeel T Quiroz 41, Alejandra Guerrero Barragan 42, David Huepe 43, Fabricio Joao Pio 44, Claudia Kimie Suemoto 45, Renata Kochhann 46, Silvia Kochen 47, Fiona Kumfor 48, Serggio Lanata 49, Bruce Miller 49, Leticia Lessa Mansur 50, Mirna Lie Hosogi 51, Patricia Lillo 52, Jorge Llibre Guerra 53, David Lira 16, Francisco Lopera 54, Adelina Comas 55, José Alberto Avila-Funes 56, Ana Luisa Sosa 57, Claudia Ramos 58, Elisa de Paula França Resende 58, Heather M Snyder 59, Ioannis Tarnanas 18 35, Jenifer Yokoyama 49, Juan Llibre 60, Juan Felipe Cardona 61, Kate Possin 49, Kenneth S Kosik 62, Rosa Montesinos 16, Sebastian Moguilner 58, Patricia Cristina Lourdes Solis 47, Renata Eloah de Lucena Ferretti-Rebustini 63, Jeronimo Martin Ramirez 64, Diana Matallana 65, Lingani Mbakile-Mahlanza 66, Alyne Mendonça Marques Ton 67, Ronnielly Melo Tavares 68, Eliane C Miotto 69, Graciela Muniz-Terrera 70, Luis Arnoldo Muñoz-Nevárez 71, David Orozco 72, Maira Okada de Oliveira 58, Olivier Piguet 73, Maritza Pintado Caipa 58, Stefanie Danielle Piña Escudero 58, Lucas Porcello Schilling 74, André Luiz Rodrigues Palmeira 75, Mônica Sanches Yassuda 76, Jose Manuel Santacruz-Escudero 77, Rodrigo Bernardo Serafim 78, Jerusa Smid 79, Andrea Slachevsky 80, Cecilia Serrano 81, Marcio Soto-Añari 82, Leonel Tadao Takada 83, Lea Tenenholz Grinberg 84, Antonio Lucio Teixeira 85, Maira Tonidandel Barbosa 86, Dominic Trépel 87, Agustin Ibanez 88 Affiliations 1School of Psychological Sciences and Health, Graham Hills Building, Glasgow, G1 1QE, UK, Universidad Autónoma del Caribe, Programa de Psicología, University of Strathclyde, Barranquilla, Colombia. 2Universidad de los Andes, Bogotá, Colombia. 3Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Buenos Aires, Argentina. 4Cognitive Neuroscience Center (CNC), Universidad de San Andres, Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Buenos Aires, Argentina. 5Pontificia Universidad Javeriana, Medical School, Physiology and Psychiatry Departments, Memory and Cognition Center Intellectus, Hospital Universitario San Ignacio, Bogotá, Colombia. 6Department of Internal Medicine, Faculty of Medicine of Jundiaí, Group of Investigation on Multimorbidity and Mental Health in Aging (GIMMA), Jundiaí, State of São Paulo, Brazil. 7Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Federal University of São Paulo - UNIFESP, São Paulo, Brazil. 8INECO Foundation, Institute of Cognitive and Translational Neuroscience (INCYT), Favaloro University, Buenos Aires, Argentina. 9Department of Clinical Medicine, Federal University of Minas Gerais, Brazil. 10Medical School, Geriatric Unit, Memory and Cognition Center-Intellectus, Aging Institute, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogotá, Colombia. 11Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. 12Neurology Service, Hospital de Clínicas de Porto Alegre e Universidade Federal do Rio Grande do Sul, Brazil. 13Laboratory of Molecular Neuropsychiatry, INECO Foundation, National Scientific and Technical Research Council, Institute of Cognitive and Translational Neuroscience (INCyT), Favaloro University, Buenos Aires, Argentina. 14Department of Speech and Language Pathology, Atlantic Fellow for Equity in Brain Health, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil. 15Center for Integrative Biology, Faculty of Sciences, FONDAP Center for Geroscience, Brain Health and Metabolism, Santiago, Chile, The Buck Institute for Research on Aging, Universidad Mayor, Chile, Novato, CA, USA. 16Unit Cognitive Impairment and Dementia Prevention, Cognitive Neurology Center, Peruvian Institute of Neurosciences, Lima, Perú. 17Centro Uruguayo de Imagenología Molecular (CUDIM), Centro de Medicina Nuclear e Imagenología Molecular, Hospital de Clínicas, Universidad de la República, Montevideo, Uruguay. 18Global Brain Health Institute, University of California, San Francisco, USA. 19Behavioral and Cognitive Neurology Unit, Department of Neurology and LIM 22, University of São Paulo, São Paulo, Brazil. 20Cognitive and Behavioral Neurology Group, University of Sao Paulo, São Paulo, Brazil. 21Laboratory of Experimental Air Pollution (LIM05), Department of Pathology, School of Medicine, Global Brain Health Institute, University of California, San Francisco (UCSF), University of São Paulo, São Paulo, Sao Paulo, Brazil. 22Department Neurology and Neurosurgery North/Department of Neurosciences, Center for Advanced Clinical Research (CICA), Faculty of Medicine, Universidad de Chile, Santiago, Chile. 23Federal University of Rio de Janeiro, Brazil/Queen's University, Canada. 24Department of Neurodegenerative Disease, University College London, London, ES, UK. 25Institute of Medical Biochemistry Leopoldo de Meis & Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. 26Division of Neurology, University of São Paulo, São Paulo, Brazil. 27Department of Neurology, University of Campinas (UNICAMP), Brazil. 28Hospital Geral de Fortaleza, University of Fortaleza, Brazil. 29Geriatrics Section Clinical Hospital University of Chile, Santos Dumont 999 Independencia, Santiago, Chile. 30Cognitive Neuroscience Center (CNC), Faculty of Education, National University of Cuyo (UNCuyo), Universidad de San Andres. National Scientific and Technical Research Council (CONICET), Mendoza, Argentina. 31School of Public Health, Cayetano Heredia University. 32Laboratory of Psychiatric Neuroimaging (LIM-21), Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil. 33Memory Clinic, Neuromedicenter, Ecuadorian Dementia Association, Quito, Ecuador. 34Facultad de Medicina de la Universidad de la República, Montevideo, Uruguay. 35Altoida Inc., Houston, Texas, USA. 36Department of Genomic Medicine, Lerner Research Institute, Cleveland Clinic, OH, USA. 37Center for Geroscience, Brain Health and Metabolism (GERO), Santiago, Chile, and Department of Biology, Faculty of Sciences, University of Chile, Santiago, Chile. 38Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA. 39Fundacion Instituto Leloir-IIBBA-CONICET. Ave, Argentina. 40Department of Neurology, University of São Paulo Medical School, São Paulo, Brazil. 41Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 42Trinity College Dublin, Dublin, Departamento de Neurologia Hospital Occidente de Kennedy, Global Brain Health Institute, Universidad de la Sabana, Bogota, Colombia. 43Center for Social and Cognitive Neuroscience (CSCN), School of Psychology, Universidad Adolfo Ibañez, Santiago, Chile. 44Department of Neurology, Hospital Governador Celso Ramos, Florianopolis, Brazil. 45Division of Geriatrics, University of Sao Paulo, Sao Paulo, Brazil. 46Graduate Program in Psychology, School of Health Sciences, Hospital Moinhos de Vento, Pontifical Catholic University of Rio Grande do Sul-PUCRS and Researcher Office, Porto Alegre, Brazil. 47Neurosciences and Complex Systems Unit (EnyS), CONICET, Hosp, El Cruce "N. Kirchner", Univ. National A, Jauretche (UNAJ), F. Varela, Prov. Buenos Aires. Fac. Medicine, Univ Nacional de Buenos Aires (UBA), Buenos Aires, Argentina. 48Brain and Mind Centre and School of Psychology, University of Sydney, Sydney, NSW, Australia. 49UCSF Department of Neurology, Memory and Aging Center, UCSF, San Francisco, California, US. 50[deceased] São Paulo University, São Paulo, Brazil. 51Behavioral and Cognitive Unit of Department of Neurology, University of São Paulo School of Medicine, Sao Paulo, Brazil. 52Geroscience Center for Brain Health and Metabolism, Santiago, Chile, Departamento de Neurología Sur/Departamento de Neurociencia, Facultad de Medicina, Universidad de Chile, Santiago, Chile. 53Global Brain Health Institute, UCSF, California, US. 54Neuroscience Research Group, Universidad de Antioquia, Medellín, Colombia. 55Department of Health Policy at the London School of Economics and Political Science, London, UK. 56Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México. 57Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México. 58Global Brain Health Institute, University of California, San Francisco (UCSF), San Francisco, USA. 59Division of Medical and Scientific Relations, Alzheimer's Association. 60Centro de estudios de Alzheimer, Cuba. 61Universidad del Valle, Cali, Colombia, USA. 62Neuroscience Research Institute and Dept of Molecular Cellular and Developmental Biology, University of California Santa, Barbara, California, USA. 63Medical-surgical Nursing Department, University of São Paulo School of Nursing, São Paulo, Brazil. 64Departamen de Admision Continua Adultos Hospital General La Raza Instituto Mexicano del Seguro Social, Global Brain Health Institute, Trinity College Dublin, Dublin, Ciudad de Mexico, Mexico. 65Medical School, Aging Institute and Psychiatry Department, Pontificia Universidad Javeriana. Memory and Cognition Center-Intellectus, Hospital Universitario San Ignacio, Bogotá, Colombia. 66Global Brain Health Institute, University of California San Francisco, University of Botswana, Gaborone, Botswana. 67Laboratory of Translational Medicine, Vila Velha University, Espírito Santo, Brazil. 68Behavioral Neurology Clinic Santa Casa de Belo Horizonte, MG, Brazil. 69Department of Neurology, University of Sao Paulo, Sao Paulo, Brazil. 70Centre for Dementia Prevention, University of Edinburgh, Scotland, UK. 71Global Brain Health Institute, University of California San Francisco, San Francisco, USA. 72Cognitive Neuroscience Development Laboratory, Axis Neurociencias, Universidad Nacional del Sur, Cognitive Impairment and Behavior Disorders Unit, Bahía Blanca, Argentina. 73School of Psychology and Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia. 74Department of Neurology, Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil. 75Santa Casa de Misericórdia de Porto Alegre, Serviço de Neurologia, Porto Alegre, Brazil, Hospital Ernesto Dornelles, Serviço de Neurologia e Neurocirurgia, Porto Alegre, Brazil. 76School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, Brazil. 77Medical School and Psychiatry Department, Memory and Cognition Center- Intellectus, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio, Bogotá, Colombia. 78Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. 79Department of Neurology, University of Sao Paulo, São Paulo, Brazil. 80Neurology Department, Geroscience Center for Brain Health and Metabolism, Santiago, Chile, Laboratory of Neuropsychology and Clinical Neuroscience (LANNEC), Physiopathology Program-ICBM, East Neurologic and Neurosciences Departments, Faculty of Medicine, Hospital del Salvador and Faculty of Medicine University of Chile. Servicio de Neurología, Departamento de Medicina, Clínica Alemana-Universidad del Desarrollo, University of Chile, Neuropsychiatry and Memory Disorders clinic (CMYN), Santiago, Chile. 81Memory and Balance Clinic, Buenos Aires, Argentina. 82Universidad Católica San Pablo, Arequipa, Perú. 83Hospital das Clinicas, University of Sao Paulo Medical School, Brazil. 84Departments of Neurology, Pathology and Global Brain Health Institute, UCSF - USA, Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil. 85Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Av. Alfredo Balena, 110, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. 86Faculdade de Medicina da Universidade Federal de Minas Gerais e Faculdade deCiências Médicas de Minas Gerais, Belo Horizonte, Brazil. 87Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin. 88Cognitive Neuroscience Center (CNC) Buenos Aires, Argentina; Universidad Autonoma del Caribe, Barranquilla, Colombia; Global Brain Health Institute (GBHI), US, Universidad de San Andres, CONICET, Universidad Autonoma del Caribe, Universidad Adolfo Ibanez, UCSF, USA. |
| dc.format.extent.es.fl_str_mv | 19 p. |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Parra M, Baez S, Sedeño L y otros. Dementia in Latin America: Paving the way toward a regional action plan. Alzheimer's & Dementia [en línea]. 2021;17(2):295-313 |
| dc.identifier.doi.none.fl_str_mv | 10.1002/alz.12202 |
| dc.identifier.eissn.none.fl_str_mv | 1552-5279 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/55541 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | Elsevier |
| dc.relation.none.fl_str_mv | Alzheimer's & Dementia. 2021;17(2):295-313 |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | Latin America Biomarkers Clinical trials Dementia Epidemiology Evidence-based recommendations Genetics Knowledge to action framework Networking and translational research Nonpharmacological interventions |
| dc.subject.other.es.fl_str_mv | BIOMARCADORES DEMENCIA EPIDEMIOLOGÍA PRÁCTICA CLÍNICA BASADA EN LA EVIDENCIA TERAPÉUTICA HUMANOS FACTORES SOCIOECONÓMICOS |
| dc.title.none.fl_str_mv | Dementia in Latin America: Paving the way toward a regional action plan |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Mario Alfredo Parra 1, Sandra Baez 2, Lucas Sedeño 3, Cecilia Gonzalez Campo 4, Hernando Santamaría-García 5, Ivan Aprahamian 6, Paulo Hf Bertolucci 7, Julian Bustin 8, Maria Aparecida Camargos Bicalho 9, Carlos Cano-Gutierrez 10, Paulo Caramelli 11, Marcia L F Chaves 12, Patricia Cogram 13, Bárbara Costa Beber 14, Felipe A Court 15, Leonardo Cruz de Souza 11, Nilton Custodio 16, Andres Damian 17, Myriam de la Cruz 18, Roberta Diehl Rodriguez 19, Sonia Maria Dozzi Brucki 20, Lais Fajersztajn 21, Gonzalo A Farías 22, Fernanda G De Felice 23, Raffaele Ferrari 24, Fabricio Ferreira de Oliveira 7, Sergio T Ferreira 25, Ceres Ferretti 26, Marcio Luiz Figueredo Balthazar 27, Norberto Anizio Ferreira Frota 28, Patricio Fuentes 29, Adolfo M García 30, Patricia J Garcia 31, Fábio Henrique de Gobbi Porto 32, Lissette Duque Peñailillo 33, Henry Willy Engler 34, Irene Maier 35, Ignacio F Mata 36, Christian Gonzalez-Billault 37, Oscar L Lopez 38, Laura Morelli 39, Ricardo Nitrini 40, Yakeel T Quiroz 41, Alejandra Guerrero Barragan 42, David Huepe 43, Fabricio Joao Pio 44, Claudia Kimie Suemoto 45, Renata Kochhann 46, Silvia Kochen 47, Fiona Kumfor 48, Serggio Lanata 49, Bruce Miller 49, Leticia Lessa Mansur 50, Mirna Lie Hosogi 51, Patricia Lillo 52, Jorge Llibre Guerra 53, David Lira 16, Francisco Lopera 54, Adelina Comas 55, José Alberto Avila-Funes 56, Ana Luisa Sosa 57, Claudia Ramos 58, Elisa de Paula França Resende 58, Heather M Snyder 59, Ioannis Tarnanas 18 35, Jenifer Yokoyama 49, Juan Llibre 60, Juan Felipe Cardona 61, Kate Possin 49, Kenneth S Kosik 62, Rosa Montesinos 16, Sebastian Moguilner 58, Patricia Cristina Lourdes Solis 47, Renata Eloah de Lucena Ferretti-Rebustini 63, Jeronimo Martin Ramirez 64, Diana Matallana 65, Lingani Mbakile-Mahlanza 66, Alyne Mendonça Marques Ton 67, Ronnielly Melo Tavares 68, Eliane C Miotto 69, Graciela Muniz-Terrera 70, Luis Arnoldo Muñoz-Nevárez 71, David Orozco 72, Maira Okada de Oliveira 58, Olivier Piguet 73, Maritza Pintado Caipa 58, Stefanie Danielle Piña Escudero 58, Lucas Porcello Schilling 74, André Luiz Rodrigues Palmeira 75, Mônica Sanches Yassuda 76, Jose Manuel Santacruz-Escudero 77, Rodrigo Bernardo Serafim 78, Jerusa Smid 79, Andrea Slachevsky 80, Cecilia Serrano 81, Marcio Soto-Añari 82, Leonel Tadao Takada 83, Lea Tenenholz Grinberg 84, Antonio Lucio Teixeira 85, Maira Tonidandel Barbosa 86, Dominic Trépel 87, Agustin Ibanez 88 |
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| identifier_str_mv | Parra M, Baez S, Sedeño L y otros. Dementia in Latin America: Paving the way toward a regional action plan. Alzheimer's & Dementia [en línea]. 2021;17(2):295-313 10.1002/alz.12202 1552-5279 |
| instacron_str | Universidad de la República |
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| spelling | Parra Mario Alfredo, Universidad Autónoma del Caribe (Colombia). Programa de PsicologíaBaez Sandra, Universidad de los Andes (Colombia)Sedeño Lucas, Consejo Nacional de Investigaciones Científicas y Tecnológicas (Argentina)Gonzalez Campo Cecilia, Universidad de San Andrés (Argentina). Centro de Neurociencias Cognitivas; Consejo Nacional de Investigaciones Científicas y Tecnológicas (Argentina)Damian Andrés, Universidad de la República (Uruguay). Facultad de Medicina. Hospital de Clínicas. Centro Uruguayo de Imagenología MolecularEngler Henry Willy, Universidad de la República (Uruguay). Facultad de MedicinaAMÉRICA LATINA2026-06-16T15:14:01Z2026-06-16T15:14:01Z2021Parra M, Baez S, Sedeño L y otros. Dementia in Latin America: Paving the way toward a regional action plan. Alzheimer's & Dementia [en línea]. 2021;17(2):295-313https://hdl.handle.net/20.500.12008/5554110.1002/alz.122021552-5279Mario Alfredo Parra 1, Sandra Baez 2, Lucas Sedeño 3, Cecilia Gonzalez Campo 4, Hernando Santamaría-García 5, Ivan Aprahamian 6, Paulo Hf Bertolucci 7, Julian Bustin 8, Maria Aparecida Camargos Bicalho 9, Carlos Cano-Gutierrez 10, Paulo Caramelli 11, Marcia L F Chaves 12, Patricia Cogram 13, Bárbara Costa Beber 14, Felipe A Court 15, Leonardo Cruz de Souza 11, Nilton Custodio 16, Andres Damian 17, Myriam de la Cruz 18, Roberta Diehl Rodriguez 19, Sonia Maria Dozzi Brucki 20, Lais Fajersztajn 21, Gonzalo A Farías 22, Fernanda G De Felice 23, Raffaele Ferrari 24, Fabricio Ferreira de Oliveira 7, Sergio T Ferreira 25, Ceres Ferretti 26, Marcio Luiz Figueredo Balthazar 27, Norberto Anizio Ferreira Frota 28, Patricio Fuentes 29, Adolfo M García 30, Patricia J Garcia 31, Fábio Henrique de Gobbi Porto 32, Lissette Duque Peñailillo 33, Henry Willy Engler 34, Irene Maier 35, Ignacio F Mata 36, Christian Gonzalez-Billault 37, Oscar L Lopez 38, Laura Morelli 39, Ricardo Nitrini 40, Yakeel T Quiroz 41, Alejandra Guerrero Barragan 42, David Huepe 43, Fabricio Joao Pio 44, Claudia Kimie Suemoto 45, Renata Kochhann 46, Silvia Kochen 47, Fiona Kumfor 48, Serggio Lanata 49, Bruce Miller 49, Leticia Lessa Mansur 50, Mirna Lie Hosogi 51, Patricia Lillo 52, Jorge Llibre Guerra 53, David Lira 16, Francisco Lopera 54, Adelina Comas 55, José Alberto Avila-Funes 56, Ana Luisa Sosa 57, Claudia Ramos 58, Elisa de Paula França Resende 58, Heather M Snyder 59, Ioannis Tarnanas 18 35, Jenifer Yokoyama 49, Juan Llibre 60, Juan Felipe Cardona 61, Kate Possin 49, Kenneth S Kosik 62, Rosa Montesinos 16, Sebastian Moguilner 58, Patricia Cristina Lourdes Solis 47, Renata Eloah de Lucena Ferretti-Rebustini 63, Jeronimo Martin Ramirez 64, Diana Matallana 65, Lingani Mbakile-Mahlanza 66, Alyne Mendonça Marques Ton 67, Ronnielly Melo Tavares 68, Eliane C Miotto 69, Graciela Muniz-Terrera 70, Luis Arnoldo Muñoz-Nevárez 71, David Orozco 72, Maira Okada de Oliveira 58, Olivier Piguet 73, Maritza Pintado Caipa 58, Stefanie Danielle Piña Escudero 58, Lucas Porcello Schilling 74, André Luiz Rodrigues Palmeira 75, Mônica Sanches Yassuda 76, Jose Manuel Santacruz-Escudero 77, Rodrigo Bernardo Serafim 78, Jerusa Smid 79, Andrea Slachevsky 80, Cecilia Serrano 81, Marcio Soto-Añari 82, Leonel Tadao Takada 83, Lea Tenenholz Grinberg 84, Antonio Lucio Teixeira 85, Maira Tonidandel Barbosa 86, Dominic Trépel 87, Agustin Ibanez 88Affiliations 1School of Psychological Sciences and Health, Graham Hills Building, Glasgow, G1 1QE, UK, Universidad Autónoma del Caribe, Programa de Psicología, University of Strathclyde, Barranquilla, Colombia. 2Universidad de los Andes, Bogotá, Colombia. 3Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Buenos Aires, Argentina. 4Cognitive Neuroscience Center (CNC), Universidad de San Andres, Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Buenos Aires, Argentina. 5Pontificia Universidad Javeriana, Medical School, Physiology and Psychiatry Departments, Memory and Cognition Center Intellectus, Hospital Universitario San Ignacio, Bogotá, Colombia. 6Department of Internal Medicine, Faculty of Medicine of Jundiaí, Group of Investigation on Multimorbidity and Mental Health in Aging (GIMMA), Jundiaí, State of São Paulo, Brazil. 7Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Federal University of São Paulo - UNIFESP, São Paulo, Brazil. 8INECO Foundation, Institute of Cognitive and Translational Neuroscience (INCYT), Favaloro University, Buenos Aires, Argentina. 9Department of Clinical Medicine, Federal University of Minas Gerais, Brazil. 10Medical School, Geriatric Unit, Memory and Cognition Center-Intellectus, Aging Institute, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogotá, Colombia. 11Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. 12Neurology Service, Hospital de Clínicas de Porto Alegre e Universidade Federal do Rio Grande do Sul, Brazil. 13Laboratory of Molecular Neuropsychiatry, INECO Foundation, National Scientific and Technical Research Council, Institute of Cognitive and Translational Neuroscience (INCyT), Favaloro University, Buenos Aires, Argentina. 14Department of Speech and Language Pathology, Atlantic Fellow for Equity in Brain Health, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil. 15Center for Integrative Biology, Faculty of Sciences, FONDAP Center for Geroscience, Brain Health and Metabolism, Santiago, Chile, The Buck Institute for Research on Aging, Universidad Mayor, Chile, Novato, CA, USA. 16Unit Cognitive Impairment and Dementia Prevention, Cognitive Neurology Center, Peruvian Institute of Neurosciences, Lima, Perú. 17Centro Uruguayo de Imagenología Molecular (CUDIM), Centro de Medicina Nuclear e Imagenología Molecular, Hospital de Clínicas, Universidad de la República, Montevideo, Uruguay. 18Global Brain Health Institute, University of California, San Francisco, USA. 19Behavioral and Cognitive Neurology Unit, Department of Neurology and LIM 22, University of São Paulo, São Paulo, Brazil. 20Cognitive and Behavioral Neurology Group, University of Sao Paulo, São Paulo, Brazil. 21Laboratory of Experimental Air Pollution (LIM05), Department of Pathology, School of Medicine, Global Brain Health Institute, University of California, San Francisco (UCSF), University of São Paulo, São Paulo, Sao Paulo, Brazil. 22Department Neurology and Neurosurgery North/Department of Neurosciences, Center for Advanced Clinical Research (CICA), Faculty of Medicine, Universidad de Chile, Santiago, Chile. 23Federal University of Rio de Janeiro, Brazil/Queen's University, Canada. 24Department of Neurodegenerative Disease, University College London, London, ES, UK. 25Institute of Medical Biochemistry Leopoldo de Meis & Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. 26Division of Neurology, University of São Paulo, São Paulo, Brazil. 27Department of Neurology, University of Campinas (UNICAMP), Brazil. 28Hospital Geral de Fortaleza, University of Fortaleza, Brazil. 29Geriatrics Section Clinical Hospital University of Chile, Santos Dumont 999 Independencia, Santiago, Chile. 30Cognitive Neuroscience Center (CNC), Faculty of Education, National University of Cuyo (UNCuyo), Universidad de San Andres. National Scientific and Technical Research Council (CONICET), Mendoza, Argentina. 31School of Public Health, Cayetano Heredia University. 32Laboratory of Psychiatric Neuroimaging (LIM-21), Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil. 33Memory Clinic, Neuromedicenter, Ecuadorian Dementia Association, Quito, Ecuador. 34Facultad de Medicina de la Universidad de la República, Montevideo, Uruguay. 35Altoida Inc., Houston, Texas, USA. 36Department of Genomic Medicine, Lerner Research Institute, Cleveland Clinic, OH, USA. 37Center for Geroscience, Brain Health and Metabolism (GERO), Santiago, Chile, and Department of Biology, Faculty of Sciences, University of Chile, Santiago, Chile. 38Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA. 39Fundacion Instituto Leloir-IIBBA-CONICET. Ave, Argentina. 40Department of Neurology, University of São Paulo Medical School, São Paulo, Brazil. 41Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 42Trinity College Dublin, Dublin, Departamento de Neurologia Hospital Occidente de Kennedy, Global Brain Health Institute, Universidad de la Sabana, Bogota, Colombia. 43Center for Social and Cognitive Neuroscience (CSCN), School of Psychology, Universidad Adolfo Ibañez, Santiago, Chile. 44Department of Neurology, Hospital Governador Celso Ramos, Florianopolis, Brazil. 45Division of Geriatrics, University of Sao Paulo, Sao Paulo, Brazil. 46Graduate Program in Psychology, School of Health Sciences, Hospital Moinhos de Vento, Pontifical Catholic University of Rio Grande do Sul-PUCRS and Researcher Office, Porto Alegre, Brazil. 47Neurosciences and Complex Systems Unit (EnyS), CONICET, Hosp, El Cruce "N. Kirchner", Univ. National A, Jauretche (UNAJ), F. Varela, Prov. Buenos Aires. Fac. Medicine, Univ Nacional de Buenos Aires (UBA), Buenos Aires, Argentina. 48Brain and Mind Centre and School of Psychology, University of Sydney, Sydney, NSW, Australia. 49UCSF Department of Neurology, Memory and Aging Center, UCSF, San Francisco, California, US. 50[deceased] São Paulo University, São Paulo, Brazil. 51Behavioral and Cognitive Unit of Department of Neurology, University of São Paulo School of Medicine, Sao Paulo, Brazil. 52Geroscience Center for Brain Health and Metabolism, Santiago, Chile, Departamento de Neurología Sur/Departamento de Neurociencia, Facultad de Medicina, Universidad de Chile, Santiago, Chile. 53Global Brain Health Institute, UCSF, California, US. 54Neuroscience Research Group, Universidad de Antioquia, Medellín, Colombia. 55Department of Health Policy at the London School of Economics and Political Science, London, UK. 56Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México. 57Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México. 58Global Brain Health Institute, University of California, San Francisco (UCSF), San Francisco, USA. 59Division of Medical and Scientific Relations, Alzheimer's Association. 60Centro de estudios de Alzheimer, Cuba. 61Universidad del Valle, Cali, Colombia, USA. 62Neuroscience Research Institute and Dept of Molecular Cellular and Developmental Biology, University of California Santa, Barbara, California, USA. 63Medical-surgical Nursing Department, University of São Paulo School of Nursing, São Paulo, Brazil. 64Departamen de Admision Continua Adultos Hospital General La Raza Instituto Mexicano del Seguro Social, Global Brain Health Institute, Trinity College Dublin, Dublin, Ciudad de Mexico, Mexico. 65Medical School, Aging Institute and Psychiatry Department, Pontificia Universidad Javeriana. Memory and Cognition Center-Intellectus, Hospital Universitario San Ignacio, Bogotá, Colombia. 66Global Brain Health Institute, University of California San Francisco, University of Botswana, Gaborone, Botswana. 67Laboratory of Translational Medicine, Vila Velha University, Espírito Santo, Brazil. 68Behavioral Neurology Clinic Santa Casa de Belo Horizonte, MG, Brazil. 69Department of Neurology, University of Sao Paulo, Sao Paulo, Brazil. 70Centre for Dementia Prevention, University of Edinburgh, Scotland, UK. 71Global Brain Health Institute, University of California San Francisco, San Francisco, USA. 72Cognitive Neuroscience Development Laboratory, Axis Neurociencias, Universidad Nacional del Sur, Cognitive Impairment and Behavior Disorders Unit, Bahía Blanca, Argentina. 73School of Psychology and Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia. 74Department of Neurology, Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil. 75Santa Casa de Misericórdia de Porto Alegre, Serviço de Neurologia, Porto Alegre, Brazil, Hospital Ernesto Dornelles, Serviço de Neurologia e Neurocirurgia, Porto Alegre, Brazil. 76School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, Brazil. 77Medical School and Psychiatry Department, Memory and Cognition Center- Intellectus, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio, Bogotá, Colombia. 78Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. 79Department of Neurology, University of Sao Paulo, São Paulo, Brazil. 80Neurology Department, Geroscience Center for Brain Health and Metabolism, Santiago, Chile, Laboratory of Neuropsychology and Clinical Neuroscience (LANNEC), Physiopathology Program-ICBM, East Neurologic and Neurosciences Departments, Faculty of Medicine, Hospital del Salvador and Faculty of Medicine University of Chile. Servicio de Neurología, Departamento de Medicina, Clínica Alemana-Universidad del Desarrollo, University of Chile, Neuropsychiatry and Memory Disorders clinic (CMYN), Santiago, Chile. 81Memory and Balance Clinic, Buenos Aires, Argentina. 82Universidad Católica San Pablo, Arequipa, Perú. 83Hospital das Clinicas, University of Sao Paulo Medical School, Brazil. 84Departments of Neurology, Pathology and Global Brain Health Institute, UCSF - USA, Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil. 85Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Av. Alfredo Balena, 110, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. 86Faculdade de Medicina da Universidade Federal de Minas Gerais e Faculdade deCiências Médicas de Minas Gerais, Belo Horizonte, Brazil. 87Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin. 88Cognitive Neuroscience Center (CNC) Buenos Aires, Argentina; Universidad Autonoma del Caribe, Barranquilla, Colombia; Global Brain Health Institute (GBHI), US, Universidad de San Andres, CONICET, Universidad Autonoma del Caribe, Universidad Adolfo Ibanez, UCSF, USA.Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.Submitted by Almiñana María Cecilia (marialminana@gmail.com) on 2026-06-15T16:53:37Z No. of bitstreams: 2 license_rdf: 26648 bytes, checksum: e9507f17d292a045f834ee111e4d098b (MD5) Dementia in Latin America.pdf: 17383288 bytes, checksum: c5106ffe1ce6b5008b36f29bafe7a934 (MD5)Approved for entry into archive by Almiñana María Cecilia (marialminana@gmail.com) on 2026-06-16T14:18:45Z (GMT) No. of bitstreams: 2 license_rdf: 26648 bytes, checksum: e9507f17d292a045f834ee111e4d098b (MD5) Dementia in Latin America.pdf: 17383288 bytes, checksum: c5106ffe1ce6b5008b36f29bafe7a934 (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2026-06-16T15:14:01Z (GMT). No. of bitstreams: 2 license_rdf: 26648 bytes, checksum: e9507f17d292a045f834ee111e4d098b (MD5) Dementia in Latin America.pdf: 17383288 bytes, checksum: c5106ffe1ce6b5008b36f29bafe7a934 (MD5) Previous issue date: 202119 p.application/pdfenengElsevierAlzheimer's & Dementia. 2021;17(2):295-313Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0)Latin AmericaBiomarkersClinical trialsDementiaEpidemiologyEvidence-based recommendationsGeneticsKnowledge to action frameworkNetworking and translational researchNonpharmacological interventionsBIOMARCADORESDEMENCIAEPIDEMIOLOGÍAPRÁCTICA CLÍNICA BASADA EN LA EVIDENCIATERAPÉUTICAHUMANOSFACTORES SOCIOECONÓMICOSDementia in Latin America: Paving the way toward a regional action planArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaParra, Mario AlfredoBaez, SandraSedeño, LucasGonzalez Campo, CeciliaDamian, AndrésEngler, Henry WillyLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/55541/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; 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- Universidad de la Repúblicafalse |
| spellingShingle | Dementia in Latin America: Paving the way toward a regional action plan Parra, Mario Alfredo Latin America Biomarkers Clinical trials Dementia Epidemiology Evidence-based recommendations Genetics Knowledge to action framework Networking and translational research Nonpharmacological interventions BIOMARCADORES DEMENCIA EPIDEMIOLOGÍA PRÁCTICA CLÍNICA BASADA EN LA EVIDENCIA TERAPÉUTICA HUMANOS FACTORES SOCIOECONÓMICOS |
| status_str | publishedVersion |
| title | Dementia in Latin America: Paving the way toward a regional action plan |
| title_full | Dementia in Latin America: Paving the way toward a regional action plan |
| title_fullStr | Dementia in Latin America: Paving the way toward a regional action plan |
| title_full_unstemmed | Dementia in Latin America: Paving the way toward a regional action plan |
| title_short | Dementia in Latin America: Paving the way toward a regional action plan |
| title_sort | Dementia in Latin America: Paving the way toward a regional action plan |
| topic | Latin America Biomarkers Clinical trials Dementia Epidemiology Evidence-based recommendations Genetics Knowledge to action framework Networking and translational research Nonpharmacological interventions BIOMARCADORES DEMENCIA EPIDEMIOLOGÍA PRÁCTICA CLÍNICA BASADA EN LA EVIDENCIA TERAPÉUTICA HUMANOS FACTORES SOCIOECONÓMICOS |
| url | https://hdl.handle.net/20.500.12008/55541 |
