Quantitative melanoma diagnosis using Spectral Phasor Analysis of Hyperspectral Imaging from label-free slices
Resumen:
Melanoma diagnosis traditionally relies on microscopic examination of hematoxylin and eosin (H&E) slides by dermatopathologists to search for specific architectural and cytological features. Unfortunately, no single molecular marker exists to reliably differentiatemelanoma from benign lesions such as nevi. This study explored the potential of autofluorescent molecules within tissues to provide molecular fingerprints indicative of degenerated melanocytes in melanoma.
| 2023 | |
| Los autores agradecen el apoyo del PEDECIBA y de la Agencia Nacional de Investigación e Innovación (ANII) como miembros del Sistema Nacional de Investigadores (SNI) | |
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Skin cancer Melanoma Fluorescence microscopy Hyperspectral imaging Phasor analysis Spectral phasor Nevus Cancer |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
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https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1296826/full#h1
https://hdl.handle.net/20.500.12008/41340 |
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| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| Sumario: | Melanoma diagnosis traditionally relies on microscopic examination of hematoxylin and eosin (H&E) slides by dermatopathologists to search for specific architectural and cytological features. Unfortunately, no single molecular marker exists to reliably differentiatemelanoma from benign lesions such as nevi. This study explored the potential of autofluorescent molecules within tissues to provide molecular fingerprints indicative of degenerated melanocytes in melanoma. |
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