Lung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory Properties
Resumen:
Lung cancer is the first leading cause of cancer-related deaths in the world. Aberrant glycosylation in lung tumors leads to the expression of tumor-associated carbohydrate structures, such as the Tn antigen, consisting of N-acetyl-galactosamine (GalNAc) linked to a serine or threonine residue in proteins (α-GalNAc-O-Ser/Thr). The Tn antigen can be recognized by the Macrophage Galactose/GalNAc lectin (MGL), which mediates various immune regulatory and tolerogenic functions, mainly by reprogramming the maturation of function of dendritic cells (DCs). In this work, we generated two different Tn-expressing variants from the Lewis-type lung murine cancer cell line LL/2, which showed different alterations in the O-glycosylation pathways that influenced the interaction with mouse MGL2 and the immunomodulatory properties of DCs. Thus, the identification of the biological programs triggered by Tn+ cancer cells might contribute to an improved understanding of the molecular mechanisms elicited by MGL-dependent immune regulatory circuits.
| 2022 | |
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Lung cancer Tn antigen Macrophage galactose-type lectin ¨Dendritic cells O-glycosylation NEOPLASIAS PULMONARES MACRÓFAGOS GALECTINAS ANTÍGENOS CÉLULAS DENDRÍTICAS GLICOSILACIÓN ACETILGALACTOSAMINA |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/54622 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| _version_ | 1875692823723900928 |
|---|---|
| author | da Costa, Valeria |
| author2 | Mariño, Karina V. Rodríguez-Zraquia, Santiago A. Festari, María Florencia Lores, Pablo Costa, Monique Landeira, Mercedes Rabinovich, Gabriel A. van Vliet, Sandra J. Freire, Teresa |
| author2_role | author author author author author author author author author |
| author_facet | da Costa, Valeria Mariño, Karina V. Rodríguez-Zraquia, Santiago A. Festari, María Florencia Lores, Pablo Costa, Monique Landeira, Mercedes Rabinovich, Gabriel A. van Vliet, Sandra J. Freire, Teresa |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | da Costa Valeria, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y Vacunas Mariño Karina V., Consejo Nacional de Investigaciones Científicas y Técnicas (Argentina). Instituto de Biología y Medicina Experimental. Laboratorio de Glicómica Funcional y Molecular Rodríguez-Zraquia Santiago A., Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y Vacunas Festari María Florencia, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y Vacunas Lores Pablo, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y Vacunas Costa Monique, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y Vacunas Landeira Mercedes, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y Vacunas Rabinovich Gabriel A., Consejo Nacional de Investigaciones Científicas y Técnicas (Argentina). Instituto de Biología y Medicina Experimental. Laboratorio de Glicomedicina van Vliet Sandra J., Vrije Universiteit Amsterdam (Países Bajos). Department of Molecular Cell Biology and Immunology Freire Teresa, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y Vacunas |
| dc.creator.none.fl_str_mv | da Costa, Valeria Mariño, Karina V. Rodríguez-Zraquia, Santiago A. Festari, María Florencia Lores, Pablo Costa, Monique Landeira, Mercedes Rabinovich, Gabriel A. van Vliet, Sandra J. Freire, Teresa |
| dc.date.accessioned.none.fl_str_mv | 2026-04-27T22:47:54Z |
| dc.date.available.none.fl_str_mv | 2026-04-27T22:47:54Z |
| dc.date.issued.none.fl_str_mv | 2022 |
| dc.description.abstract.none.fl_txt_mv | Lung cancer is the first leading cause of cancer-related deaths in the world. Aberrant glycosylation in lung tumors leads to the expression of tumor-associated carbohydrate structures, such as the Tn antigen, consisting of N-acetyl-galactosamine (GalNAc) linked to a serine or threonine residue in proteins (α-GalNAc-O-Ser/Thr). The Tn antigen can be recognized by the Macrophage Galactose/GalNAc lectin (MGL), which mediates various immune regulatory and tolerogenic functions, mainly by reprogramming the maturation of function of dendritic cells (DCs). In this work, we generated two different Tn-expressing variants from the Lewis-type lung murine cancer cell line LL/2, which showed different alterations in the O-glycosylation pathways that influenced the interaction with mouse MGL2 and the immunomodulatory properties of DCs. Thus, the identification of the biological programs triggered by Tn+ cancer cells might contribute to an improved understanding of the molecular mechanisms elicited by MGL-dependent immune regulatory circuits. |
| dc.format.extent.es.fl_str_mv | 14 p. |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | da Costa V, Mariño K, Rodríguez-Zraquia S y otros. Lung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory Properties. International Journal of Molecular Sciences [en línea]. 2022;23(19). 14 p. |
| dc.identifier.doi.none.fl_str_mv | 10.3390/ijms231912047 |
| dc.identifier.eissn.none.fl_str_mv | 1422-0067 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/54622 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | International Journal of Molecular Sciences. 2022;23(19) |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | Lung cancer Tn antigen Macrophage galactose-type lectin ¨Dendritic cells O-glycosylation |
| dc.subject.other.es.fl_str_mv | NEOPLASIAS PULMONARES MACRÓFAGOS GALECTINAS ANTÍGENOS CÉLULAS DENDRÍTICAS GLICOSILACIÓN ACETILGALACTOSAMINA |
| dc.title.none.fl_str_mv | Lung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory Properties |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Lung cancer is the first leading cause of cancer-related deaths in the world. Aberrant glycosylation in lung tumors leads to the expression of tumor-associated carbohydrate structures, such as the Tn antigen, consisting of N-acetyl-galactosamine (GalNAc) linked to a serine or threonine residue in proteins (α-GalNAc-O-Ser/Thr). The Tn antigen can be recognized by the Macrophage Galactose/GalNAc lectin (MGL), which mediates various immune regulatory and tolerogenic functions, mainly by reprogramming the maturation of function of dendritic cells (DCs). In this work, we generated two different Tn-expressing variants from the Lewis-type lung murine cancer cell line LL/2, which showed different alterations in the O-glycosylation pathways that influenced the interaction with mouse MGL2 and the immunomodulatory properties of DCs. Thus, the identification of the biological programs triggered by Tn+ cancer cells might contribute to an improved understanding of the molecular mechanisms elicited by MGL-dependent immune regulatory circuits. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_c421e99e89f5fd5404e734415f5e29a1 |
| identifier_str_mv | da Costa V, Mariño K, Rodríguez-Zraquia S y otros. Lung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory Properties. International Journal of Molecular Sciences [en línea]. 2022;23(19). 14 p. 10.3390/ijms231912047 1422-0067 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/54622 |
| publishDate | 2022 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | karina.camps@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | da Costa Valeria, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y VacunasMariño Karina V., Consejo Nacional de Investigaciones Científicas y Técnicas (Argentina). Instituto de Biología y Medicina Experimental. Laboratorio de Glicómica Funcional y MolecularRodríguez-Zraquia Santiago A., Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y VacunasFestari María Florencia, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y VacunasLores Pablo, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y VacunasCosta Monique, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y VacunasLandeira Mercedes, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y VacunasRabinovich Gabriel A., Consejo Nacional de Investigaciones Científicas y Técnicas (Argentina). Instituto de Biología y Medicina Experimental. Laboratorio de Glicomedicinavan Vliet Sandra J., Vrije Universiteit Amsterdam (Países Bajos). Department of Molecular Cell Biology and ImmunologyFreire Teresa, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y Vacunas2026-04-27T22:47:54Z2026-04-27T22:47:54Z2022da Costa V, Mariño K, Rodríguez-Zraquia S y otros. Lung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory Properties. International Journal of Molecular Sciences [en línea]. 2022;23(19). 14 p.https://hdl.handle.net/20.500.12008/5462210.3390/ijms2319120471422-0067Lung cancer is the first leading cause of cancer-related deaths in the world. Aberrant glycosylation in lung tumors leads to the expression of tumor-associated carbohydrate structures, such as the Tn antigen, consisting of N-acetyl-galactosamine (GalNAc) linked to a serine or threonine residue in proteins (α-GalNAc-O-Ser/Thr). The Tn antigen can be recognized by the Macrophage Galactose/GalNAc lectin (MGL), which mediates various immune regulatory and tolerogenic functions, mainly by reprogramming the maturation of function of dendritic cells (DCs). In this work, we generated two different Tn-expressing variants from the Lewis-type lung murine cancer cell line LL/2, which showed different alterations in the O-glycosylation pathways that influenced the interaction with mouse MGL2 and the immunomodulatory properties of DCs. Thus, the identification of the biological programs triggered by Tn+ cancer cells might contribute to an improved understanding of the molecular mechanisms elicited by MGL-dependent immune regulatory circuits.Submitted by Almiñana María Cecilia (marialminana@gmail.com) on 2026-04-27T14:37:47Z No. of bitstreams: 2 license_rdf: 25630 bytes, checksum: e7132498e7c1fe99f7096667baa99b25 (MD5) Lung Tumor Cells with Different Tn Antigen Expression.pdf: 19285267 bytes, checksum: 616ce6d07ab2ecea9a070b64cd8bd86c (MD5)Approved for entry into archive by Almiñana María Cecilia (marialminana@gmail.com) on 2026-04-27T15:48:22Z (GMT) No. of bitstreams: 2 license_rdf: 25630 bytes, checksum: e7132498e7c1fe99f7096667baa99b25 (MD5) Lung Tumor Cells with Different Tn Antigen Expression.pdf: 19285267 bytes, checksum: 616ce6d07ab2ecea9a070b64cd8bd86c (MD5)Made available in DSpace by Camps Karina (karina.camps@seciu.edu.uy) on 2026-04-27T22:47:54Z (GMT). No. of bitstreams: 2 license_rdf: 25630 bytes, checksum: e7132498e7c1fe99f7096667baa99b25 (MD5) Lung Tumor Cells with Different Tn Antigen Expression.pdf: 19285267 bytes, checksum: 616ce6d07ab2ecea9a070b64cd8bd86c (MD5) Previous issue date: 202214 p.application/pdfenengMDPIInternational Journal of Molecular Sciences. 2022;23(19)Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)Lung cancerTn antigenMacrophage galactose-type lectin¨Dendritic cellsO-glycosylationNEOPLASIAS PULMONARESMACRÓFAGOSGALECTINASANTÍGENOSCÉLULAS DENDRÍTICASGLICOSILACIÓNACETILGALACTOSAMINALung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory PropertiesArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la Repúblicada Costa, ValeriaMariño, Karina V.Rodríguez-Zraquia, Santiago A.Festari, María FlorenciaLores, PabloCosta, MoniqueLandeira, MercedesRabinovich, Gabriel A.van Vliet, Sandra J.Freire, TeresaLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/54622/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; 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- Universidad de la Repúblicafalse |
| spellingShingle | Lung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory Properties da Costa, Valeria Lung cancer Tn antigen Macrophage galactose-type lectin ¨Dendritic cells O-glycosylation NEOPLASIAS PULMONARES MACRÓFAGOS GALECTINAS ANTÍGENOS CÉLULAS DENDRÍTICAS GLICOSILACIÓN ACETILGALACTOSAMINA |
| status_str | publishedVersion |
| title | Lung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory Properties |
| title_full | Lung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory Properties |
| title_fullStr | Lung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory Properties |
| title_full_unstemmed | Lung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory Properties |
| title_short | Lung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory Properties |
| title_sort | Lung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory Properties |
| topic | Lung cancer Tn antigen Macrophage galactose-type lectin ¨Dendritic cells O-glycosylation NEOPLASIAS PULMONARES MACRÓFAGOS GALECTINAS ANTÍGENOS CÉLULAS DENDRÍTICAS GLICOSILACIÓN ACETILGALACTOSAMINA |
| url | https://hdl.handle.net/20.500.12008/54622 |
