Microwave-assisted solid-phase synthesis of nicotinyl hydrazones for use in radiochemistry of technetium-99m
Resumen:
We report a new method for efficient and rapid synthesis of HYNIC-hydrazone derivatives using microwaveassisted solid-phase. In comparison to the conventional heating procedure, microwave irradiation considerably accelerated the formation of HYNIC analogues. The synthesis time and efforts are significantly reduced in the present method, without side product formation. We proved that the HYNIC-hydrazone clustering can be directly labeled with technetium without exposing the free hydrazine group. Therefore, this is a useful tool to obtain HYNIC-bioconjugates for use in 99mTc radiochemistry.
| 2018 | |
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Chelation Hydrazone HYNIC Microwave Solid-phase Technetium-99m |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/26344 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| _version_ | 1807522784243351552 |
|---|---|
| author | Teixeira, Vania |
| author2 | Cabral González, Pablo Porcal, Williams |
| author2_role | author author |
| author_facet | Teixeira, Vania Cabral González, Pablo Porcal, Williams |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Teixeira Vania, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares Cabral González Pablo, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares Porcal Williams, Universidad de la República (Uruguay). Facultad de Química |
| dc.creator.none.fl_str_mv | Teixeira, Vania Cabral González, Pablo Porcal, Williams |
| dc.date.accessioned.none.fl_str_mv | 2021-01-14T12:13:45Z |
| dc.date.available.none.fl_str_mv | 2021-01-14T12:13:45Z |
| dc.date.issued.none.fl_str_mv | 2018 |
| dc.description.abstract.none.fl_txt_mv | We report a new method for efficient and rapid synthesis of HYNIC-hydrazone derivatives using microwaveassisted solid-phase. In comparison to the conventional heating procedure, microwave irradiation considerably accelerated the formation of HYNIC analogues. The synthesis time and efforts are significantly reduced in the present method, without side product formation. We proved that the HYNIC-hydrazone clustering can be directly labeled with technetium without exposing the free hydrazine group. Therefore, this is a useful tool to obtain HYNIC-bioconjugates for use in 99mTc radiochemistry. |
| dc.format.extent.es.fl_str_mv | 10 h. |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Teixeira, V, Cabral González, P y Porcal, W. "Microwave-assisted solid-phase synthesis of nicotinyl hydrazones for use in radiochemistry of technetium-99m". Arkivoc. [en línea] 2018, (5), pp. 29-38. 10 h. doi: 10.24820/ark.5550190.p010.065 |
| dc.identifier.doi.none.fl_str_mv | 10.24820/ark.5550190.p010.065 |
| dc.identifier.issn.none.fl_str_mv | 1551-7004 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/26344 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | Arkat |
| dc.relation.ispartof.es.fl_str_mv | Arkivoc, 2018, (5), pp. 29-38. |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | Chelation Hydrazone HYNIC Microwave Solid-phase Technetium-99m |
| dc.title.none.fl_str_mv | Microwave-assisted solid-phase synthesis of nicotinyl hydrazones for use in radiochemistry of technetium-99m |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | We report a new method for efficient and rapid synthesis of HYNIC-hydrazone derivatives using microwaveassisted solid-phase. In comparison to the conventional heating procedure, microwave irradiation considerably accelerated the formation of HYNIC analogues. The synthesis time and efforts are significantly reduced in the present method, without side product formation. We proved that the HYNIC-hydrazone clustering can be directly labeled with technetium without exposing the free hydrazine group. Therefore, this is a useful tool to obtain HYNIC-bioconjugates for use in 99mTc radiochemistry. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_c1f20c39d571de71c2891a701e941559 |
| identifier_str_mv | Teixeira, V, Cabral González, P y Porcal, W. "Microwave-assisted solid-phase synthesis of nicotinyl hydrazones for use in radiochemistry of technetium-99m". Arkivoc. [en línea] 2018, (5), pp. 29-38. 10 h. doi: 10.24820/ark.5550190.p010.065 1551-7004 10.24820/ark.5550190.p010.065 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/26344 |
| publishDate | 2018 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | mabel.seroubian@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Teixeira Vania, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones NuclearesCabral González Pablo, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones NuclearesPorcal Williams, Universidad de la República (Uruguay). Facultad de Química2021-01-14T12:13:45Z2021-01-14T12:13:45Z2018Teixeira, V, Cabral González, P y Porcal, W. "Microwave-assisted solid-phase synthesis of nicotinyl hydrazones for use in radiochemistry of technetium-99m". Arkivoc. [en línea] 2018, (5), pp. 29-38. 10 h. doi: 10.24820/ark.5550190.p010.0651551-7004https://hdl.handle.net/20.500.12008/2634410.24820/ark.5550190.p010.065We report a new method for efficient and rapid synthesis of HYNIC-hydrazone derivatives using microwaveassisted solid-phase. In comparison to the conventional heating procedure, microwave irradiation considerably accelerated the formation of HYNIC analogues. The synthesis time and efforts are significantly reduced in the present method, without side product formation. We proved that the HYNIC-hydrazone clustering can be directly labeled with technetium without exposing the free hydrazine group. Therefore, this is a useful tool to obtain HYNIC-bioconjugates for use in 99mTc radiochemistry.Submitted by Parodi Mónica (mparodi@fcien.edu.uy) on 2021-01-13T12:29:51Z No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 1024820ark5550190p010065.pdf: 1348001 bytes, checksum: 5aa6a292b4ec3d3d814907350152c3a2 (MD5)Approved for entry into archive by Faget Cecilia (lfaget@fcien.edu.uy) on 2021-01-14T11:29:33Z (GMT) No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 1024820ark5550190p010065.pdf: 1348001 bytes, checksum: 5aa6a292b4ec3d3d814907350152c3a2 (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@fic.edu.uy) on 2021-01-14T12:13:45Z (GMT). No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 1024820ark5550190p010065.pdf: 1348001 bytes, checksum: 5aa6a292b4ec3d3d814907350152c3a2 (MD5) Previous issue date: 201810 h.application/pdfenengArkatArkivoc, 2018, (5), pp. 29-38.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)ChelationHydrazoneHYNICMicrowaveSolid-phaseTechnetium-99mMicrowave-assisted solid-phase synthesis of nicotinyl hydrazones for use in radiochemistry of technetium-99mArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaTeixeira, VaniaCabral González, PabloPorcal, WilliamsLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/26344/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-844http://localhost:8080/xmlui/bitstream/20.500.12008/26344/2/license_urla0ebbeafb9d2ec7cbb19d7137ebc392cMD52license_textlicense_texttext/html; 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- Universidad de la Repúblicafalse |
| spellingShingle | Microwave-assisted solid-phase synthesis of nicotinyl hydrazones for use in radiochemistry of technetium-99m Teixeira, Vania Chelation Hydrazone HYNIC Microwave Solid-phase Technetium-99m |
| status_str | publishedVersion |
| title | Microwave-assisted solid-phase synthesis of nicotinyl hydrazones for use in radiochemistry of technetium-99m |
| title_full | Microwave-assisted solid-phase synthesis of nicotinyl hydrazones for use in radiochemistry of technetium-99m |
| title_fullStr | Microwave-assisted solid-phase synthesis of nicotinyl hydrazones for use in radiochemistry of technetium-99m |
| title_full_unstemmed | Microwave-assisted solid-phase synthesis of nicotinyl hydrazones for use in radiochemistry of technetium-99m |
| title_short | Microwave-assisted solid-phase synthesis of nicotinyl hydrazones for use in radiochemistry of technetium-99m |
| title_sort | Microwave-assisted solid-phase synthesis of nicotinyl hydrazones for use in radiochemistry of technetium-99m |
| topic | Chelation Hydrazone HYNIC Microwave Solid-phase Technetium-99m |
| url | https://hdl.handle.net/20.500.12008/26344 |
