Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research

Mateescu, Bogdan - Jones, Jennifer C. - Alexander, Roger P. - Alsop, Eric - An, Ji Yeong - Asghari, Mohammad - Boomgarden, Alex - Bouchareychas, Laura - Cayota, Alfonso - Chang, Hsueh-Chia - Charest, Al - Chiu, Daniel T. - Tosar, Juan P.

Resumen:

The extracellular RNA communication consortium (ERCC) is an NIH-funded program aiming to promote the development of new technologies, resources, and knowledge about exRNAs and their carriers. After Phase 1 (2013-2018), Phase 2 of the program (ERCC2, 2019-2023) aims to fill critical gaps in knowledge and technology to enable rigorous and reproducible methods for separation and characterization of both bulk populations of exRNA carriers and single EVs. ERCC2 investigators are also developing new bioinformatic pipelines to promote data integration through the exRNA atlas database. ERCC2 has established several Working Groups (Resource Sharing, Reagent Development, Data Analysis and Coordination, Technology Development, nomenclature, and Scientific Outreach) to promote collaboration between ERCC2 members and the broader scientific community. We expect that ERCC2's current and future achievements will significantly improve our understanding of exRNA biology and the development of accurate and efficient exRNA-based diagnostic, prognostic, and theranostic biomarker assays.

Detalles Bibliográficos
2022
Biochemistry
Biological sciences
Cell biology
Molecular biology
TRANSPORTE DE ARN
BIOLOGÍA MOLECULAR
BIOLOGÍA CELULAR
BIOQUÍMICA
DISCIPLINAS DE LAS CIENCIAS BIOLÓGICAS
Inglés
Universidad de la República
COLIBRI
https://hdl.handle.net/20.500.12008/54763
Acceso abierto
Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)
Resumen:
Sumario:Bogdan Mateescu 1 2, Jennifer C Jones 3, Roger P Alexander 4, Eric Alsop 5, Ji Yeong An 6, Mohammad Asghari 2, Alex Boomgarden 7, Laura Bouchareychas 8 9, Alfonso Cayota 10 11, Hsueh-Chia Chang 12 13, Al Charest 14, Daniel T Chiu 15, Robert J Coffey 16 17, Saumya Das 18, Peter De Hoff 19, Andrew deMello 2, Crislyn D'Souza-Schorey 7, David Elashoff 20, Kiarash R Eliato 21, Jeffrey L Franklin 16 17, David J Galas 22, Mark B Gerstein 23 24 25, Ionita H Ghiran 14, David B Go 12 13, Stephen Gould 26, Tristan R Grogan 27, James N Higginbotham 16, Florian Hladik 28 29, Tony Jun Huang 30, Xiaoye Huo 12, Elizabeth Hutchins 5, Dennis K Jeppesen 16, Tijana Jovanovic-Talisman 21, Betty Y S Kim 31, Sung Kim 6, Kyoung-Mee Kim 32, Yong Kim 33, Robert R Kitchen 34, Vaughan Knouse 3, Emily L LaPlante 35, Carlito B Lebrilla 36, L James Lee 37, Kathleen M Lennon 21, Guoping Li 18, Feng Li 33, Tieyi Li 38, Tao Liu 39, Zirui Liu 38, Adam L Maddox 21, Kyle McCarthy 12, Bessie Meechoovet 5, Nalin Maniya 12, Yingchao Meng 2, Aleksandar Milosavljevic 35 40, Byoung-Hoon Min 41, Amber Morey 19, Martin Ng 9, John Nolan 42, Getulio P De Oliveira Junior 14, Michael E Paulaitis 43, Tuan Anh Phu 9, Robert L Raffai 8 9 44, Eduardo Reátegui 37, Matthew E Roth 35, David A Routenberg 45, Joel Rozowsky 23, Joseph Rufo 30, Satyajyoti Senapati 12, Sigal Shachar 45, Himani Sharma 12, Anil K Sood 46, Stavros Stavrakis 2, Alessandra Stürchler 1 2, Muneesh Tewari 47 48 49 50, Juan P Tosar 10 51, Alexander K Tucker-Schwartz 45, Andrey Turchinovich 52 53, Nedyalka Valkov 18, Kendall Van Keuren-Jensen 5, Kasey C Vickers 54, Lucia Vojtech 55, Wyatt N Vreeland 56, Ceming Wang 12, Kai Wang 57, ZeYu Wang 30, Joshua A Welsh 3, Kenneth W Witwer 58 59, David T W Wong 33, Jianping Xia 30, Ya-Hong Xie 38, Kaichun Yang 30, Mikołaj P Zaborowski 60, Chenguang Zhang 12, Qin Zhang 16, Angela M Zivkovic 61, Louise C Laurent 19