Development of fluorescent- and radio- traceable T1307-polymeric micelles as biomedical agents for cancer diagnosis: biodistribution on 4T1 tumor-bearing mice
Resumen:
In recent years, nanocarriers have been studied as promising pharmaceutical tools for controlled drug-delivery, treatment-efficacy follow-up and disease imaging. Among them, X-shaped amphiphilic polymeric micelles (Tetronic®, poloxamines) display great potential due to their biocompatibility and non-toxic effects, among others. In the present work, polymeric micelles based on the T1307 copolymer were initially decorated with a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-fluorophore in order to determinate its in vivo biodistribution on 4T1 tumor-bearing mice. However, unfavorable results with this probe led to two different strategies. On the one hand, the BODIPY-loaded micelles, L-T1307-BODIPY, and on the other hand, the 99mTc-radiolabeled micelles, L-T1307-99mTc, were analyzed separately in vivo. The results indicated that T1307 accumulates mainly in the stomach, the kidneys, the lungs and the tumor, reaching the maximum organccumulation 2 hours after intravenous injection. Additionally, and according to the results obtained for L-T1307-99mTc, the capture of the polymeric micelles in organs could be observed up to 24 hours after injection. The results obtained in this work were promising towards the development of new radiotracer agents for breast cancer based on X-shaped polymeric micelles.
| 2022 | |
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ANII: POS_FCE_2015_1_1005193 ANII: POS_FCE_1_2014_1_104714 |
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Amphiphilic polymeric micelles T1307. BODIPY 99m Tc. In vivo biodistribution |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/39924 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC - By 4.0) |
| _version_ | 1807522799495938048 |
|---|---|
| author | Lecot Calandria, Nicole Valerie |
| author2 | Rodríguez, Gonzalo Stancov Vázquez, Valentina Fernández Silveira, Marcelo González, Mercedes Glisoni, Romina J. Cabral González, Pablo Cerecetto, Hugo |
| author2_role | author author author author author author author |
| author_facet | Lecot Calandria, Nicole Valerie Rodríguez, Gonzalo Stancov Vázquez, Valentina Fernández Silveira, Marcelo González, Mercedes Glisoni, Romina J. Cabral González, Pablo Cerecetto, Hugo |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Lecot Calandria Nicole Valerie, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. Rodríguez Gonzalo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. Stancov Vázquez Valentina, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. Fernández Silveira Marcelo, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. González Mercedes, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. Glisoni Romina J. Cabral González Pablo, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. Cerecetto Hugo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. |
| dc.creator.none.fl_str_mv | Lecot Calandria, Nicole Valerie Rodríguez, Gonzalo Stancov Vázquez, Valentina Fernández Silveira, Marcelo González, Mercedes Glisoni, Romina J. Cabral González, Pablo Cerecetto, Hugo |
| dc.date.accessioned.none.fl_str_mv | 2023-09-18T15:07:10Z |
| dc.date.available.none.fl_str_mv | 2023-09-18T15:07:10Z |
| dc.date.issued.none.fl_str_mv | 2022 |
| dc.description.abstract.none.fl_txt_mv | In recent years, nanocarriers have been studied as promising pharmaceutical tools for controlled drug-delivery, treatment-efficacy follow-up and disease imaging. Among them, X-shaped amphiphilic polymeric micelles (Tetronic®, poloxamines) display great potential due to their biocompatibility and non-toxic effects, among others. In the present work, polymeric micelles based on the T1307 copolymer were initially decorated with a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-fluorophore in order to determinate its in vivo biodistribution on 4T1 tumor-bearing mice. However, unfavorable results with this probe led to two different strategies. On the one hand, the BODIPY-loaded micelles, L-T1307-BODIPY, and on the other hand, the 99mTc-radiolabeled micelles, L-T1307-99mTc, were analyzed separately in vivo. The results indicated that T1307 accumulates mainly in the stomach, the kidneys, the lungs and the tumor, reaching the maximum organccumulation 2 hours after intravenous injection. Additionally, and according to the results obtained for L-T1307-99mTc, the capture of the polymeric micelles in organs could be observed up to 24 hours after injection. The results obtained in this work were promising towards the development of new radiotracer agents for breast cancer based on X-shaped polymeric micelles. |
| dc.description.sponsorship.none.fl_txt_mv | ANII: POS_FCE_2015_1_1005193 ANII: POS_FCE_1_2014_1_104714 |
| dc.format.extent.es.fl_str_mv | 13 h. |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Lecot Calandria, N, Rodríguez, G, Stancov Vázquez, V [y otros autores]. "Development of fluorescent- and radio- traceable T1307-polymeric micelles as biomedical agents for cancer diagnosis: biodistribution on 4T1 tumor-bearing mice". Brazilian Journal of Pharmaceutical Sciences. [en línea] 2022, 58: e191055.13 h. DOI: 10.1590/s2175-97902022e191055 |
| dc.identifier.doi.none.fl_str_mv | 10.1590/s2175-97902022e191055 |
| dc.identifier.issn.none.fl_str_mv | 19848250 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/39924 |
| dc.language.iso.none.fl_str_mv | en_US eng |
| dc.publisher.es.fl_str_mv | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas |
| dc.relation.ispartof.es.fl_str_mv | Brazilian Journal of Pharmaceutical Sciences, 2022, 58: e191055. |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | Amphiphilic polymeric micelles T1307. BODIPY 99m Tc. In vivo biodistribution |
| dc.title.none.fl_str_mv | Development of fluorescent- and radio- traceable T1307-polymeric micelles as biomedical agents for cancer diagnosis: biodistribution on 4T1 tumor-bearing mice |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | In recent years, nanocarriers have been studied as promising pharmaceutical tools for controlled drug-delivery, treatment-efficacy follow-up and disease imaging. Among them, X-shaped amphiphilic polymeric micelles (Tetronic®, poloxamines) display great potential due to their biocompatibility and non-toxic effects, among others. In the present work, polymeric micelles based on the T1307 copolymer were initially decorated with a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-fluorophore in order to determinate its in vivo biodistribution on 4T1 tumor-bearing mice. However, unfavorable results with this probe led to two different strategies. On the one hand, the BODIPY-loaded micelles, L-T1307-BODIPY, and on the other hand, the 99mTc-radiolabeled micelles, L-T1307-99mTc, were analyzed separately in vivo. The results indicated that T1307 accumulates mainly in the stomach, the kidneys, the lungs and the tumor, reaching the maximum organccumulation 2 hours after intravenous injection. Additionally, and according to the results obtained for L-T1307-99mTc, the capture of the polymeric micelles in organs could be observed up to 24 hours after injection. The results obtained in this work were promising towards the development of new radiotracer agents for breast cancer based on X-shaped polymeric micelles. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_be5d6194c7bcdb95115a36f6fb8b0f8a |
| identifier_str_mv | Lecot Calandria, N, Rodríguez, G, Stancov Vázquez, V [y otros autores]. "Development of fluorescent- and radio- traceable T1307-polymeric micelles as biomedical agents for cancer diagnosis: biodistribution on 4T1 tumor-bearing mice". Brazilian Journal of Pharmaceutical Sciences. [en línea] 2022, 58: e191055.13 h. DOI: 10.1590/s2175-97902022e191055 19848250 10.1590/s2175-97902022e191055 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en_US |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/39924 |
| publishDate | 2022 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | mabel.seroubian@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Lecot Calandria Nicole Valerie, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares.Rodríguez Gonzalo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica.Stancov Vázquez Valentina, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica.Fernández Silveira Marcelo, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares.González Mercedes, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica.Glisoni Romina J.Cabral González Pablo, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares.Cerecetto Hugo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica.2023-09-18T15:07:10Z2023-09-18T15:07:10Z2022Lecot Calandria, N, Rodríguez, G, Stancov Vázquez, V [y otros autores]. "Development of fluorescent- and radio- traceable T1307-polymeric micelles as biomedical agents for cancer diagnosis: biodistribution on 4T1 tumor-bearing mice". Brazilian Journal of Pharmaceutical Sciences. [en línea] 2022, 58: e191055.13 h. DOI: 10.1590/s2175-97902022e19105519848250https://hdl.handle.net/20.500.12008/3992410.1590/s2175-97902022e191055In recent years, nanocarriers have been studied as promising pharmaceutical tools for controlled drug-delivery, treatment-efficacy follow-up and disease imaging. Among them, X-shaped amphiphilic polymeric micelles (Tetronic®, poloxamines) display great potential due to their biocompatibility and non-toxic effects, among others. In the present work, polymeric micelles based on the T1307 copolymer were initially decorated with a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-fluorophore in order to determinate its in vivo biodistribution on 4T1 tumor-bearing mice. However, unfavorable results with this probe led to two different strategies. On the one hand, the BODIPY-loaded micelles, L-T1307-BODIPY, and on the other hand, the 99mTc-radiolabeled micelles, L-T1307-99mTc, were analyzed separately in vivo. The results indicated that T1307 accumulates mainly in the stomach, the kidneys, the lungs and the tumor, reaching the maximum organccumulation 2 hours after intravenous injection. Additionally, and according to the results obtained for L-T1307-99mTc, the capture of the polymeric micelles in organs could be observed up to 24 hours after injection. The results obtained in this work were promising towards the development of new radiotracer agents for breast cancer based on X-shaped polymeric micelles.Submitted by Farías Verónica (vfarias@fcien.edu.uy) on 2023-09-11T13:46:16Z No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 101590s217597902022e191055.pdf: 1009586 bytes, checksum: 28a91a2fe8ea7309ee43cacf3c86b667 (MD5)Approved for entry into archive by Faget Cecilia (lfaget@fcien.edu.uy) on 2023-09-18T12:35:01Z (GMT) No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 101590s217597902022e191055.pdf: 1009586 bytes, checksum: 28a91a2fe8ea7309ee43cacf3c86b667 (MD5)Made available in DSpace by Seroubian Mabel (mabel.seroubian@seciu.edu.uy) on 2023-09-18T15:07:10Z (GMT). No. of bitstreams: 2 license_rdf: 19875 bytes, checksum: 9fdbed07f52437945402c4e70fa4773e (MD5) 101590s217597902022e191055.pdf: 1009586 bytes, checksum: 28a91a2fe8ea7309ee43cacf3c86b667 (MD5) Previous issue date: 2022ANII: POS_FCE_2015_1_1005193ANII: POS_FCE_1_2014_1_10471413 h.application/pdfen_USengUniversidade de São Paulo, Faculdade de Ciências FarmacêuticasBrazilian Journal of Pharmaceutical Sciences, 2022, 58: e191055.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)Amphiphilic polymeric micellesT1307. BODIPY99m Tc.In vivo biodistributionDevelopment of fluorescent- and radio- traceable T1307-polymeric micelles as biomedical agents for cancer diagnosis: biodistribution on 4T1 tumor-bearing miceArtículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaLecot Calandria, Nicole ValerieRodríguez, GonzaloStancov Vázquez, ValentinaFernández Silveira, MarceloGonzález, MercedesGlisoni, Romina J.Cabral González, PabloCerecetto, HugoLICENSElicense.txtlicense.txttext/plain; charset=utf-84267http://localhost:8080/xmlui/bitstream/20.500.12008/39924/5/license.txt6429389a7df7277b72b7924fdc7d47a9MD55CC-LICENSElicense_urllicense_urltext/plain; charset=utf-844http://localhost:8080/xmlui/bitstream/20.500.12008/39924/2/license_urla0ebbeafb9d2ec7cbb19d7137ebc392cMD52license_textlicense_texttext/html; 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- Universidad de la Repúblicafalse |
| spellingShingle | Development of fluorescent- and radio- traceable T1307-polymeric micelles as biomedical agents for cancer diagnosis: biodistribution on 4T1 tumor-bearing mice Lecot Calandria, Nicole Valerie Amphiphilic polymeric micelles T1307. BODIPY 99m Tc. In vivo biodistribution |
| status_str | publishedVersion |
| title | Development of fluorescent- and radio- traceable T1307-polymeric micelles as biomedical agents for cancer diagnosis: biodistribution on 4T1 tumor-bearing mice |
| title_full | Development of fluorescent- and radio- traceable T1307-polymeric micelles as biomedical agents for cancer diagnosis: biodistribution on 4T1 tumor-bearing mice |
| title_fullStr | Development of fluorescent- and radio- traceable T1307-polymeric micelles as biomedical agents for cancer diagnosis: biodistribution on 4T1 tumor-bearing mice |
| title_full_unstemmed | Development of fluorescent- and radio- traceable T1307-polymeric micelles as biomedical agents for cancer diagnosis: biodistribution on 4T1 tumor-bearing mice |
| title_short | Development of fluorescent- and radio- traceable T1307-polymeric micelles as biomedical agents for cancer diagnosis: biodistribution on 4T1 tumor-bearing mice |
| title_sort | Development of fluorescent- and radio- traceable T1307-polymeric micelles as biomedical agents for cancer diagnosis: biodistribution on 4T1 tumor-bearing mice |
| topic | Amphiphilic polymeric micelles T1307. BODIPY 99m Tc. In vivo biodistribution |
| url | https://hdl.handle.net/20.500.12008/39924 |
