Clinical and epidemiological features of tuberculosis isolated from critically ill patients
Resumen:
Human tuberculosis is still a major world health concern. In Uruguay, contrary to the world trend, an increase in cases has been observed since 2006. Although the incidence of MDR-resistant strains is low and no cases of XDR-TB were registered, an increase in the number of patients with severe tuberculosis requiring critical care admission was observed. As a first aim, we performed the analysis of the genetic structure of strains isolated from patients with severe tuberculosis admitted to an intensive care unit. We compared these results with those corresponding to the general population observing a statistically significant increase in the Haarlem genotypes among ICU patients (53.3% vs 34.7%; p < 0.05). In addition, we investigated the association of clinical outcomes with the genotype observing a major incidence of hepatic dysfunctions among patients infected with the Haarlem strain (p < 0.05). The cohort presented is one of the largest studied series of critically ill patients with tuberculosis.
| 2022 | |
|
Mycobacterium Tuberculosis Pulmonary infections Critically ill patients |
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| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/39042 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| _version_ | 1807522797417660416 |
|---|---|
| author | Hurtado Gutiérrez, Joaquín Ignacio |
| author2 | Coitinho, Cecilia Nin, Nicolás Buroni, María Hurtado, Francisco Javier Robello Porto, Carlos Greif, Gonzalo |
| author2_role | author author author author author author |
| author_facet | Hurtado Gutiérrez, Joaquín Ignacio Coitinho, Cecilia Nin, Nicolás Buroni, María Hurtado, Francisco Javier Robello Porto, Carlos Greif, Gonzalo |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.none.fl_str_mv | Hurtado Gutiérrez Joaquín Ignacio, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Coitinho Cecilia, Comisión Honoraria de Lucha Antituberculosa. Nin Nicolás, ASSE Buroni María, ASSE Hurtado Francisco Javier, Universidad de la República (Uruguay). Facultad de Medicina. Robello Porto Carlos, Universidad de la República (Uruguay). Facultad de Medicina. Greif Gonzalo, Instituo Pasteur (Montevideo) |
| dc.creator.none.fl_str_mv | Hurtado Gutiérrez, Joaquín Ignacio Coitinho, Cecilia Nin, Nicolás Buroni, María Hurtado, Francisco Javier Robello Porto, Carlos Greif, Gonzalo |
| dc.date.accessioned.none.fl_str_mv | 2023-08-04T17:11:58Z |
| dc.date.available.none.fl_str_mv | 2023-08-04T17:11:58Z |
| dc.date.issued.none.fl_str_mv | 2022 |
| dc.description.abstract.none.fl_txt_mv | Human tuberculosis is still a major world health concern. In Uruguay, contrary to the world trend, an increase in cases has been observed since 2006. Although the incidence of MDR-resistant strains is low and no cases of XDR-TB were registered, an increase in the number of patients with severe tuberculosis requiring critical care admission was observed. As a first aim, we performed the analysis of the genetic structure of strains isolated from patients with severe tuberculosis admitted to an intensive care unit. We compared these results with those corresponding to the general population observing a statistically significant increase in the Haarlem genotypes among ICU patients (53.3% vs 34.7%; p < 0.05). In addition, we investigated the association of clinical outcomes with the genotype observing a major incidence of hepatic dysfunctions among patients infected with the Haarlem strain (p < 0.05). The cohort presented is one of the largest studied series of critically ill patients with tuberculosis. |
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| dc.identifier.citation.es.fl_str_mv | Hurtado Gutiérrez, J, Coitinho, C, Nin, N, [y otros autores]. "Clinical and epidemiological features of tuberculosis isolated from critically ill patients". Revista Argentina de Microbiología. [en línea] 2022, 54(1): 43-47. 5 h. DOI: 10.1016/j.ram.2021.02.011 |
| dc.identifier.doi.none.fl_str_mv | 10.1016/j.ram.2021.02.011 |
| dc.identifier.issn.none.fl_str_mv | 1851-7617 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/39042 |
| dc.language.iso.none.fl_str_mv | en_US eng |
| dc.publisher.es.fl_str_mv | Elsevier España |
| dc.relation.ispartof.es.fl_str_mv | Revista Argentina de Microbiología, 2022, 54(1): 43-47. |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | Mycobacterium Tuberculosis Pulmonary infections Critically ill patients |
| dc.title.none.fl_str_mv | Clinical and epidemiological features of tuberculosis isolated from critically ill patients |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Human tuberculosis is still a major world health concern. In Uruguay, contrary to the world trend, an increase in cases has been observed since 2006. Although the incidence of MDR-resistant strains is low and no cases of XDR-TB were registered, an increase in the number of patients with severe tuberculosis requiring critical care admission was observed. As a first aim, we performed the analysis of the genetic structure of strains isolated from patients with severe tuberculosis admitted to an intensive care unit. We compared these results with those corresponding to the general population observing a statistically significant increase in the Haarlem genotypes among ICU patients (53.3% vs 34.7%; p < 0.05). In addition, we investigated the association of clinical outcomes with the genotype observing a major incidence of hepatic dysfunctions among patients infected with the Haarlem strain (p < 0.05). The cohort presented is one of the largest studied series of critically ill patients with tuberculosis. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_b9a1338d1d2379d6283b51f009455744 |
| identifier_str_mv | Hurtado Gutiérrez, J, Coitinho, C, Nin, N, [y otros autores]. "Clinical and epidemiological features of tuberculosis isolated from critically ill patients". Revista Argentina de Microbiología. [en línea] 2022, 54(1): 43-47. 5 h. DOI: 10.1016/j.ram.2021.02.011 1851-7617 10.1016/j.ram.2021.02.011 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en_US |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/39042 |
| publishDate | 2022 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | mabel.seroubian@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| spelling | Hurtado Gutiérrez Joaquín Ignacio, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Coitinho Cecilia, Comisión Honoraria de Lucha Antituberculosa.Nin Nicolás, ASSEBuroni María, ASSEHurtado Francisco Javier, Universidad de la República (Uruguay). Facultad de Medicina.Robello Porto Carlos, Universidad de la República (Uruguay). Facultad de Medicina.Greif Gonzalo, Instituo Pasteur (Montevideo)2023-08-04T17:11:58Z2023-08-04T17:11:58Z2022Hurtado Gutiérrez, J, Coitinho, C, Nin, N, [y otros autores]. "Clinical and epidemiological features of tuberculosis isolated from critically ill patients". Revista Argentina de Microbiología. [en línea] 2022, 54(1): 43-47. 5 h. DOI: 10.1016/j.ram.2021.02.0111851-7617https://hdl.handle.net/20.500.12008/3904210.1016/j.ram.2021.02.011Human tuberculosis is still a major world health concern. In Uruguay, contrary to the world trend, an increase in cases has been observed since 2006. Although the incidence of MDR-resistant strains is low and no cases of XDR-TB were registered, an increase in the number of patients with severe tuberculosis requiring critical care admission was observed. As a first aim, we performed the analysis of the genetic structure of strains isolated from patients with severe tuberculosis admitted to an intensive care unit. We compared these results with those corresponding to the general population observing a statistically significant increase in the Haarlem genotypes among ICU patients (53.3% vs 34.7%; p < 0.05). In addition, we investigated the association of clinical outcomes with the genotype observing a major incidence of hepatic dysfunctions among patients infected with the Haarlem strain (p < 0.05). The cohort presented is one of the largest studied series of critically ill patients with tuberculosis.Submitted by Farías Verónica (vfarias@fcien.edu.uy) on 2023-08-04T16:39:28Z No. of bitstreams: 2 license_rdf: 23149 bytes, checksum: 1996b8461bc290aef6a27d78c67b6b52 (MD5) 101016jram202102011.pdf: 634276 bytes, checksum: 021fc2c4ccc15f953f8ee13f2ce5b115 (MD5)Approved for entry into archive by Faget Cecilia (lfaget@fcien.edu.uy) on 2023-08-04T16:54:23Z (GMT) No. of bitstreams: 2 license_rdf: 23149 bytes, checksum: 1996b8461bc290aef6a27d78c67b6b52 (MD5) 101016jram202102011.pdf: 634276 bytes, checksum: 021fc2c4ccc15f953f8ee13f2ce5b115 (MD5)Made available in DSpace by Luna Fabiana (fabiana.luna@seciu.edu.uy) on 2023-08-04T17:11:58Z (GMT). No. of bitstreams: 2 license_rdf: 23149 bytes, checksum: 1996b8461bc290aef6a27d78c67b6b52 (MD5) 101016jram202102011.pdf: 634276 bytes, checksum: 021fc2c4ccc15f953f8ee13f2ce5b115 (MD5) Previous issue date: 20225 h.application/pdfen_USengElsevier EspañaRevista Argentina de Microbiología, 2022, 54(1): 43-47.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. 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- Universidad de la Repúblicafalse |
| spellingShingle | Clinical and epidemiological features of tuberculosis isolated from critically ill patients Hurtado Gutiérrez, Joaquín Ignacio Mycobacterium Tuberculosis Pulmonary infections Critically ill patients |
| status_str | publishedVersion |
| title | Clinical and epidemiological features of tuberculosis isolated from critically ill patients |
| title_full | Clinical and epidemiological features of tuberculosis isolated from critically ill patients |
| title_fullStr | Clinical and epidemiological features of tuberculosis isolated from critically ill patients |
| title_full_unstemmed | Clinical and epidemiological features of tuberculosis isolated from critically ill patients |
| title_short | Clinical and epidemiological features of tuberculosis isolated from critically ill patients |
| title_sort | Clinical and epidemiological features of tuberculosis isolated from critically ill patients |
| topic | Mycobacterium Tuberculosis Pulmonary infections Critically ill patients |
| url | https://hdl.handle.net/20.500.12008/39042 |
