Human endogenous retrovirus: their relationship with hematological diseases
Resumen:
Human endogenous retrovirus (HERVs) integrated in the human genome millions of years ago and became astable part of the inherited genetic material. Most of these HERVs are dysfunctional due to numerous mutations andthus making it impossible to generate a full, infectious retrovirus particle from a single genetic locus. However, manyHERVs are still exceptionally well preserved and maintain Open Reading Frames encoding functional viral proteins.The permanence of HERV ́s genes along evolution suggests that these elements have proven beneficial to humansurvival. In this regard, the expression of certain HERV proteins is implicated in important physiological functions,such as placental development. Nevertheless, reactivation of HERVs has frequently been observed in a variety ofhuman tumors suggesting their potential to contribute to malignant progression. Considering the role of HERVs inthe carcinogenesis process, the purpose of this mini review is to deepen into HERVs expression and its possibleimplication in hemato-oncologic disease development.
| 2016 | |
|
Retroviruses Exogenous Mutations |
|
| Inglés | |
| Universidad de la República | |
| COLIBRI | |
| https://hdl.handle.net/20.500.12008/22020 | |
| Acceso abierto | |
| Licencia Creative Commons Atribución (CC –BY 4.0) |
| _version_ | 1807522779624374272 |
|---|---|
| author | Fischer Alpuin, Sabrina Carla |
| author2 | Echeverría Chagas, Natalia Cristina, Juan Moreno Karlen, María del Pilar |
| author2_role | author author author |
| author_facet | Fischer Alpuin, Sabrina Carla Echeverría Chagas, Natalia Cristina, Juan Moreno Karlen, María del Pilar |
| author_role | author |
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| collection | COLIBRI |
| dc.contributor.filiacion.es.fl_str_mv | Fischer Alpuin, Sabrina Carla. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares Echeverría Chagas, Natalia. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares Cristina Gheraldi, Juan. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares Moreno Karlen, María del Pilar. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. |
| dc.creator.none.fl_str_mv | Fischer Alpuin, Sabrina Carla Echeverría Chagas, Natalia Cristina, Juan Moreno Karlen, María del Pilar |
| dc.date.accessioned.none.fl_str_mv | 2019-10-02T22:08:29Z |
| dc.date.available.none.fl_str_mv | 2019-10-02T22:08:29Z |
| dc.date.issued.es.fl_str_mv | 2016 |
| dc.date.submitted.es.fl_str_mv | 20190930 |
| dc.description.abstract.none.fl_txt_mv | Human endogenous retrovirus (HERVs) integrated in the human genome millions of years ago and became astable part of the inherited genetic material. Most of these HERVs are dysfunctional due to numerous mutations andthus making it impossible to generate a full, infectious retrovirus particle from a single genetic locus. However, manyHERVs are still exceptionally well preserved and maintain Open Reading Frames encoding functional viral proteins.The permanence of HERV ́s genes along evolution suggests that these elements have proven beneficial to humansurvival. In this regard, the expression of certain HERV proteins is implicated in important physiological functions,such as placental development. Nevertheless, reactivation of HERVs has frequently been observed in a variety ofhuman tumors suggesting their potential to contribute to malignant progression. Considering the role of HERVs inthe carcinogenesis process, the purpose of this mini review is to deepen into HERVs expression and its possibleimplication in hemato-oncologic disease development. |
| dc.format.mimetype.es.fl_str_mv | application/pdf |
| dc.identifier.citation.es.fl_str_mv | Fischer, S., et al. Human endogenous retrovirus: their relationship with hematological diseases. Journal of Leukemia, 2016, 4 (4), art. 1000217. doi: 10.4172/2329-6917.1000217 |
| dc.identifier.doi.es.fl_str_mv | 10.4172/2329-6917.1000217 |
| dc.identifier.issn.es.fl_str_mv | 2329-6917 |
| dc.identifier.uri.none.fl_str_mv | https://hdl.handle.net/20.500.12008/22020 |
| dc.language.iso.none.fl_str_mv | en eng |
| dc.publisher.es.fl_str_mv | Longdom Group |
| dc.relation.ispartof.es.fl_str_mv | Journal of Leukemia, 2016, 4 (4), art. 1000217 |
| dc.rights.license.none.fl_str_mv | Licencia Creative Commons Atribución (CC –BY 4.0) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.es.fl_str_mv | Retroviruses Exogenous Mutations |
| dc.title.none.fl_str_mv | Human endogenous retrovirus: their relationship with hematological diseases |
| dc.type.es.fl_str_mv | Artículo |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Human endogenous retrovirus (HERVs) integrated in the human genome millions of years ago and became astable part of the inherited genetic material. Most of these HERVs are dysfunctional due to numerous mutations andthus making it impossible to generate a full, infectious retrovirus particle from a single genetic locus. However, manyHERVs are still exceptionally well preserved and maintain Open Reading Frames encoding functional viral proteins.The permanence of HERV ́s genes along evolution suggests that these elements have proven beneficial to humansurvival. In this regard, the expression of certain HERV proteins is implicated in important physiological functions,such as placental development. Nevertheless, reactivation of HERVs has frequently been observed in a variety ofhuman tumors suggesting their potential to contribute to malignant progression. Considering the role of HERVs inthe carcinogenesis process, the purpose of this mini review is to deepen into HERVs expression and its possibleimplication in hemato-oncologic disease development. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | COLIBRI_af176438c836b696ee7696ad646593ee |
| identifier_str_mv | Fischer, S., et al. Human endogenous retrovirus: their relationship with hematological diseases. Journal of Leukemia, 2016, 4 (4), art. 1000217. doi: 10.4172/2329-6917.1000217 2329-6917 10.4172/2329-6917.1000217 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | COLIBRI |
| network_name_str | COLIBRI |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/22020 |
| publishDate | 2016 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | mabel.seroubian@seciu.edu.uy |
| repository.name.fl_str_mv | COLIBRI - Universidad de la República |
| repository_id_str | 4771 |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC –BY 4.0) |
| spelling | Fischer Alpuin, Sabrina Carla. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones NuclearesEcheverría Chagas, Natalia. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones NuclearesCristina Gheraldi, Juan. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones NuclearesMoreno Karlen, María del Pilar. Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares.2019-10-02T22:08:29Z2019-10-02T22:08:29Z201620190930Fischer, S., et al. Human endogenous retrovirus: their relationship with hematological diseases. Journal of Leukemia, 2016, 4 (4), art. 1000217. doi: 10.4172/2329-6917.10002172329-6917https://hdl.handle.net/20.500.12008/2202010.4172/2329-6917.1000217 Human endogenous retrovirus (HERVs) integrated in the human genome millions of years ago and became astable part of the inherited genetic material. Most of these HERVs are dysfunctional due to numerous mutations andthus making it impossible to generate a full, infectious retrovirus particle from a single genetic locus. However, manyHERVs are still exceptionally well preserved and maintain Open Reading Frames encoding functional viral proteins.The permanence of HERV ́s genes along evolution suggests that these elements have proven beneficial to humansurvival. In this regard, the expression of certain HERV proteins is implicated in important physiological functions,such as placental development. Nevertheless, reactivation of HERVs has frequently been observed in a variety ofhuman tumors suggesting their potential to contribute to malignant progression. Considering the role of HERVs inthe carcinogenesis process, the purpose of this mini review is to deepen into HERVs expression and its possibleimplication in hemato-oncologic disease development.Made available in DSpace on 2019-10-02T22:08:29Z (GMT). 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- Universidad de la Repúblicafalse |
| spellingShingle | Human endogenous retrovirus: their relationship with hematological diseases Fischer Alpuin, Sabrina Carla Retroviruses Exogenous Mutations |
| status_str | publishedVersion |
| title | Human endogenous retrovirus: their relationship with hematological diseases |
| title_full | Human endogenous retrovirus: their relationship with hematological diseases |
| title_fullStr | Human endogenous retrovirus: their relationship with hematological diseases |
| title_full_unstemmed | Human endogenous retrovirus: their relationship with hematological diseases |
| title_short | Human endogenous retrovirus: their relationship with hematological diseases |
| title_sort | Human endogenous retrovirus: their relationship with hematological diseases |
| topic | Retroviruses Exogenous Mutations |
| url | https://hdl.handle.net/20.500.12008/22020 |
